The Effect Echinacea Purpurea Herbs in Reducing Symptoms of Upper Respiratory Infection: A Meta-Analysis

Author(s):  
Riska Fajar Fatony ◽  
◽  
Didik Gunawan Tamtomo ◽  
Hanung Prasetya ◽  
◽  
...  

Background: Echinacea possibly reduces the effectiveness of corticosteroids, commonly used by asthmatics and for treating viral induced wheeze, and can cause hypersensitivity reactions in susceptible individuals. Treatment of the common cold in children with Echinacea has only been investigated in one randomized, double blind, placebo controlled trial to examine the efficacy and safety of Echinacea purpurea in children with upper respiratory tract infections. This study aimed to investigate the effect Echinacea purpurea herbs in reducing symptoms of upper respiratory infection. Subjects and Method: This was meta-analysis and systematic review. The study was conducted by collecting published articles from PubMed, Science Direct, and Google Scholar databases. The study subject was adults with upper respiratory infection. Intervention was Echinecea purpurea herbs extract with comparison placebo. The study outcome was decreased symptoms of upper respiratory tract infection. The inclusion criteria were full text, using English language, and using randomized controlled trial. The collected articles were selected by PRISMA flow chart. The quantitative data were analyzed using Revman 5.3 Results: A meta-analysis using 6 studies from United States resulted high heterogeneity between experimental groups (I2= 98%; p<0.001), so it conducted by random effect model (REM). This study showed that provision of Echinecea purpurea herbs extract reduced symptoms of upper respiratory tract infection than placebo (Mean Difference= -0.56; 95% CI= -0.91 to -0.22; p= 0.001). Conclusion: Echinecea purpurea herbs extract reduced symptoms of upper respiratory tract infection than placebo. Keywords: Echinacea purpurea herbs extract, upper respirstory infection Correspondence: Riska Fajar Fatony. Masters Program in Public Health, Universitas Sebelas Maret. Jl. Ir. Sutami 36A, Surakarta 57126, Central Java. Email: [email protected]. Mobile: +6289508588008. DOI: https://doi.org/10.26911/the7thicph.05.58

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Y. Q. Xia ◽  
K. N. Zhao ◽  
A. D. Zhao ◽  
J. Z. Zhu ◽  
H. F. Hong ◽  
...  

Abstract Background Evidences regarding the associations between maternal upper respiratory tract infection/influenza during pregnancy and the risk of congenital heart disease (CHD) is still controversial. This study was specifically designed to examine the associations by a case-control study and a meta-analysis of the published evidences and our finding. Methods A hospital-based case-control study involving 262 children with simple CHD and 262 children with complex CHD, along with 262 control children, was conducted through June, 2016 to December, 2017. All children were aged 0–2 years old. Furthermore, a meta-analysis based on both previously published studies and our case-control study was performed. Results In the case-control study, after adjusting for possible confounders, maternal upper respiratory tract infection/influenza during early pregnancy was found to be related to an increased risk of CHD (OR = 3.40 and 95% CI: 2.05–5.62 for simple CHD; OR = 2.39 and 95% CI: 1.47–3.88 for complex CHD). After a meta-analysis, the adverse impact was still kept significant (OR = 1.47 and 95% CI: 1.28–1.67 for simple CHD; OR = 1.44 and 95% CI: 1.14–1.75 for complex CHD). The very similar associations were also observed among single type of CHD, herein, ventricular septal defects (VSD) and tetralogy of fallot (TOF) in the case-control study. In the subsequent meta-analysis, however, the significant association only existed in VSD. Conclusions Although there is still conflicting in TOF, the results are overall consistent, which provide new enforced evidence that maternal upper respiratory tract infection/influenza during early pregnancy, in general, play an important role in the occurrence of CHD.


2021 ◽  
Vol 7 (1) ◽  
pp. 8
Author(s):  
Hubah Asyiroh ◽  
Retno Asih Setyoningrum ◽  
Widati Fatmaningrum ◽  
Budi Utomo

Background: Acute respiratory tract infection (ARTI) is one of the causes of morbidity and mortality in children. This infection may happen in either the upper or lower respiratory tracts. It may also happen recurrently in some children according to the risk factors they have. This study aimed to understand the correlation between risk factors and recurrent upper respiratory tract infection in children aged 3-60 months at primary healthcare centers (Puskesmas) in Gresik.Methods: This study used an analytic observational study with cross-sectional design. The amount of sample used was 110 patients with upper respiratory infection from October 2019-April 2020 at Puskesmas Industri and Puskesmas Alun-Alun, Gresik. Data analysis was performed using chi-square test and logistic regression. The data were taken from medical records as well as questionnaires.Results: The result of bivariate analysis showed that asthma (p = 0.000), exposure to cigarette smoke (p = 0.045), healthy home status (p = 0.002), and the occupancy of the house (p = 0.019) had correlations with the occurrence of recurrent upper respiratory infection. Meanwhile, the multivariate analysis presented some variables which had significant correlation with recurrent upper respiratory tract infection such as asthma (p= 0.000), exposure to cigarette smoke (p = 0.012), and healthy home status (p = 0.001).Conclusion: There was a strong relationship between asthma, exposure to cigarette smoke, and healthy home status with the occurrence of recurrent upper respiratory tract infection (URTI) in children.


2002 ◽  
Vol 6 (18) ◽  
Author(s):  
T Panagiotopoulos ◽  
S Tsiodras ◽  
G Spala ◽  
I Kourbeti ◽  
E Triantafyllou ◽  
...  

On 9 April, headline news in a local newspaper in Crete reported the death of a previously healthy 45 year old woman in Heraklion. The death, which occurred on 5 April, was associated with myocarditis after upper respiratory tract infection. A second death (13 April) of a 48-year old woman from eastern Crete with similar symptoms was also headline news.


2020 ◽  
Vol 11 (SPL4) ◽  
pp. 2340-2343
Author(s):  
Khanwelkar ◽  
Sujata Jadhav C ◽  
Pritam M Sakhare ◽  
Sheshla Sadanandan ◽  
Thorat V M

In the present study, we have recorded the percentage of prescribing prevalence for different respiratory drugs and antibiotics and DDDs/1000inhabitants/day for different antibiotics to recognize the drug utilization trends in respiratory tract infections. In the present study, among the upper respiratory infection cases, 89.60% of the patients received antibiotics and culture was done in only 4.62% of patients. Among the lower respiratory infection cases all the patients were prescribed antibiotic therapy, culture was done in 39.58% of patients, and 55.26% was sterile. Pneumonia was found more in the age group of 41 to 70 whereas Nonspecific URTI and Sinusitis in the age group of 17 to 30. The sex distribution of the patients showed that the female constituted of 59.38% of the patients and male constituted of 40.56% of the patients. The upper respiratory tract infection constituted of 69.47% of patients and lower respiratory tract infection constituted of 31.16% of patients.


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