scholarly journals Comparative Efficacy between Intravenous Iron and Oral Iron on Enhancing Hemoglobin Level among Pregnant Women with Iron Deficiency Anemia in Low and Middle Income Countries: A Meta-Analysis

2019 ◽  
Vol 4 (2) ◽  
pp. 135-144
Author(s):  
Fiki Cahya Ningrum ◽  
◽  
Bhisma Murti ◽  
Vitri Widyaningsih ◽  
◽  
...  
2022 ◽  
Vol 1 (1) ◽  
pp. 114-121
Author(s):  
Dewita Dewita ◽  
Henniwati Henniwati ◽  
Lili Kartika Sari Hrp ◽  
Nora Veri

ABSTRAK  Anemia merupakan masalah global terutama bagi ibu hamil. Penyebab utama anemia pada kehamilan adalah defisiensi besi kemudian diikuti oleh defisiensi folat. WHO memperkirakan angka kejadian anemia sekitar 42 % terjadi pada ibu hamil dengan kondisi ekonomi menengah kebawah. Tujuan Pengabdian ini adalah untuk meningkatkan pengetahuan ibu hamil. tentang anemia defisensi besi dan pemeriksaan kadar hemoglobin sebagai deteksi dini mandiri di Desa Matang Seulimeng wilayah kerja Puskesmas Langsa Barat Kota Langsa. Bentuk kegiatan pengabdian masyarakat adalah dengan metode penyuluhan dengan ceramah dan tanya jawab. Sedangkan deteksi dini resiko tinggi dilakukan dengan pemeriksaan kadar hemoglobin dan setelah 2 minggu intervensi dilakukan evaluasi ibu hamil anemia dengan pemeriksaan kadar Hemoglobin. Terjadi perubahan peningkatan pengetahuan baik sebesar 85 % dan hasil pemeriksaan hemoglobin dari 18 ibu hamil anemia setelah evaluasi menjadi 67,8 %  tidak anemia .Penilaian mengenai pemahaman ibu hamil tentang edukasi anemia Defisiensi besi dan pemeriksaan Hemoglobin sebagai deteksi dini resiko pada ibu hamil adalah 3 (tiga) tahap (tahap pretest, tahap penyuluhan, dan tahap posttest serta evaluasi ibu hamil anemia). Adanya peningkatan pengetahuan setelah diberikan edukasi anemia defisiensi pada ibu hamil, dan mampu melakukan deteksi dini mandiri tanda gejala anemia sehingga mendapat penanganan sesegera mungkin. Kata Kunci : anemia defisiensi zat besi, kadar hemoglobin, deteksi dini, ibu hamil  ABSTRACT  Anemia is a global problem, especially for pregnant women. The main cause of anemia in pregnancy is iron deficiency followed by folate deficiency. WHO estimates that the incidence of anemia is around 42% in pregnant women with middle to lower economic conditions. The purpose of this service is to increase the knowledge of pregnant women. regarding iron deficiency anemia and hemoglobin level examination as an independent early detection in Matang Seulimeng Village, the working area of Langsa Barat Health Center, Langsa City. The form of community service activities is the extension method with lectures and questions and answers. Meanwhile, early detection of high risk is carried out by examining hemoglobin levels and after 2 weeks of intervention, pregnant women with anemia are evaluated by examining hemoglobin levels. There was an increase in knowledge of both 85% and the results of hemoglobin examination from 18 anemic pregnant women after the evaluation became 67.8% not anemic. An assessment of the understanding of pregnant women about iron deficiency anemia education and hemoglobin examination as early detection of risk in pregnant women is 3 (three) stages (pretest stage, counseling stage, and posttest stage and evaluation of anemic pregnant women). There is an increase in knowledge after being given education on deficiency anemia in pregnant women, and being able to independently detect early signs of anemia so that they get treatment as soon as possible. Keywords: iron deficiency anemia, hemoglobin levels, early detection, pregnant women


Author(s):  
Divyani Agrawal ◽  
Deepa Lokwani Masand

Background: Anemia is one of the common manageable problem among the pregnant women worldwide, which contributes to maternal and perinatal mortality. This study aims to compare the efficacy and safety of intravenous ferric carboxymaltose with intravenous iron sucrose in treating anemia during pregnancy. Objective of this study was to compare safety and efficacy of intravenous ferric carboxymaltose with intravenous ferric sucrose in iron deficiency anemia during pregnancy.Methods: It’s an interventional prospective study conducted in Department of Obstetrics and Gynecology at NIMS, Jaipur, Rajasthan, India constituting of 100 pregnant women. Group 1- 50 pregnant women were treated with intravenous ferric carboxymaltose and Group 2: 50 pregnant women were treated with intravenous iron sucrose. Hemoglobin and serum ferritin levels were measured pre and post treatment with parenteral iron therapy. The efficacy of intravenous ferric carboxymaltose in comparison to intravenous iron sucrose was assessed. The evaluation of safety and tolerance with the parenteral therapy was also performed.Results: Anemia during pregnancy was more prevalent among the reproductive age group and in multiparous women. The mean rise in the hemoglobin level with ferric carboxymaltose was 2.92 gm/dl and with that of iron, sucrose was 1.08 gm/dl. The man rise in the serum ferritin levels with ferric carboxymaltose was 64.97ng/ml and with iron sucrose was 31.64 ng/ml. Ferric carboxymaltose was observed to be safer with no adverse events in comparison to the Iron sucrose which was related with adverse events among 03 pregnant women.Conclusions: Intravenous ferric carboxymaltose was more efficacious and safer in comparison to intravenous iron sucrose among pregnant women. Hence, ferric carboxymaltose is the drug of choice in treatment of iron deficiency anemia during pregnancy.


2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Gabriela Amstad Bencaiova ◽  
Alexander Krafft ◽  
Roland Zimmermann ◽  
Tilo Burkhardt

Objective.We assess and compare the efficacy of anemia treatment in pregnant women with anemia of chronic disease with true iron deficiency and in women with iron deficiency anemia.Study Design.Fifty patients with moderate anemia (hemoglobin 8.0–9.9 g/dl) and iron deficiency (ferritin < 15 μg/l) were treated in the Anemia Clinic at the Department of Obstetrics.Results.All patients showed stimulation of erythropoiesis as evidenced by an increase in reticulocyte count at day eight of therapy and showed an increase in hemoglobin and hematocrit at the end of therapy (p<0.001). The target hemoglobin (≥10.5 g/dl) was achieved in 45/50 women (90%). 12 patients showed anemia of chronic disease with true iron deficiency (12/50; 24%). Seven women (7/12; 59%) with anemia of chronic disease and iron deficiency responded well to anemia treatment. 50% of women with anemia of chronic disease and iron deficiency (3/6) responded well to intravenous iron, and 67% (4/6) responded well to the combination of intravenous iron and recombinant human erythropoietin.Conclusion.Because of frequent true iron deficiency in pregnant women with anemia of chronic disease, anemia of chronic disease in pregnancy is often falsely diagnosed as iron deficiency anemia.


Author(s):  
Satish Kumar

Introduction: Anemia is the commonest major contributing factor in maternal mortality and morbidity in developing countries and according to World Health Organization (WHO) criteria, it contributes to 20% of maternal deaths. Anemia in pregnancy defined as hemoglobin level <11 gm/dl (7.45 mmol/L) and hematocrit less than 33% (WHO). Aim: To compare the efficacy of oral iron ferrous sulphate therapy with intravenous iron sucrose therapy in the treatment of iron deficiency anemia during postpartum period. Material & Methods: This was a prospective randomized comparative clinical trial single center study conducted on 200 postpartum women aged >18 years (after normal delivery or LSCS) within 10 days of delivery with Hb level more or equal to 6 gm/dl but less than 10 gm/dl were included in the study. This was a one year study conducted during 1st December 2018 to 30th November 2019. Results : There was a significant increase in the hemoglobin level in both the groups i.e. in IV iron group, from 8.26 ±1.03gm/dl on day 1 to 11.62±0.94gm/dl on day 45 as compared to oral iron group, from 8.24±1.09gm/dl on day 1 to 11.07±1.14gm/dl on day 45; and serum ferritin level from 41.69±40.45ng/ml on day 1 to 77.34±41.60ng/ml on day 45 in IV iron group as compared to the oral iron group from 22.20±8.82ng/ml on day 1 to 31.72±9.72 ng/ml on day 45. So, there was a rapid increase in both hemoglobin and serum ferritin levels in IV iron group as compared to the oral iron group. Conclusion: Intravenous iron sucrose administration increases the hemoglobin level and serum ferritin more rapidly in compare to the oral intake of ferrous sulphate in women with iron deficiency anemia in postpartum women in our study. Keywords: Iron deficiency anemia, Intravenous iron sucrose, Serum ferritin, Maternal mortality.


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