Drug delivery system in pain control Progression in peroral narcotics and non-steroidal anti-inflammatory drugs (NSAIDs)

2005 ◽  
Vol 20 (5) ◽  
pp. 521-529
Author(s):  
Shigeru Saeki
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Pain Control ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Imidazolium-Based Ionic Liquid-Assisted Preparation of Nano-Spheres Loaded with Bio-Active Peptides to Decrease Inflammation in an Osteoarthritis Model: Ex Vivo Evaluations

2021 ◽  
Vol 17 (5) ◽  
pp. 859-872
Author(s):  
Yingzhuo Song ◽  
Tao Zhang ◽  
Huiguang Cheng ◽  
Wei Jiang ◽  
Pu Li ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Ex Vivo ◽  
Cartilage Explants ◽  
Therapeutic Drug ◽  
Therapeutic Peptides ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Osteoarthritis is one of the most prevalent chronic diseases. Cartilage inflammation in osteoarthritis results from pain in articular joints. Anti-inflammatory drugs provide relief by hindering the production of pro-inflammatory cytokines and interleukin-6. Targeted delivery of anti-inflammatory drugs is very effective in the treatment of osteoarthritis. This approach reduces the usage of therapeutic drug dosages and unwanted side effects. Here, we fabricated a non-invasive and efficient targeted drug delivery system to reduce persistent inflammation in an osteoarthritis model. Temperature-sensitive hollow dextran/poly(N-isopropyl acrylamide) nanoparticles were synthesized by the destruction of N,N’-bis(acryloyl)cystamine crosslinked cores in imidazolium-based ionic liquids. The copolymerized 2-acrylamido-2-methylpropane sulfonic acid created sulfur functionalities that increase the loading of therapeutic KAFAK peptides. The chemical structure of the polymer nanoparticles was analyzed with UV-Visible, Fourier transform infrared, and X-ray photoelectron spectroscopy. The thermal responsive characteristics of the nanoparticles were determined with dynamic light scattering, scanning electron microscopy, and transmission electron microscopy analyses. Moreover, the synthesized nanoparticles were used as drug carriers to reduce inflammation in an Ex Vivo osteoarthritis model. The KAFAK-loaded hollow dextran/PNIPAM nanoparticles effectively delivered therapeutic peptides in cartilage explants to suppress inflammation. These thermoresponsive nanoparticles could be an effective drug delivery system to deliver anti-inflammatory therapeutic peptides in a highly osteoarthritic environment.

A drug delivery system based on switchable photo-controlled p-coumaric acid derivatives anchored on mesoporous silica

2017 ◽  
Vol 5 (4) ◽  
pp. 817-825 ◽  
Author(s):  
Eva Beňová ◽  
Vladimír Zeleňák ◽  
Dáša Halamová ◽  
Miroslav Almáši ◽  
Veronika Petrul'ová ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery System ◽  
Delivery System ◽  
Coumaric Acid ◽  
Inflammatory Drug ◽  
Anti Inflammatory

Mesoporous silica modified by p-coumaric acid derivatives as photo-switchable ligands was studied for the delivery of a non-steroidal anti-inflammatory drug.

scholarly journals A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes

2010 ◽  
Vol 18 (9) ◽  
pp. 1606-1614 ◽  
Author(s):  
Dongmei Sun ◽  
Xiaoying Zhuang ◽  
Xiaoyu Xiang ◽  
Yuelong Liu ◽  
Shuangyin Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Inflammatory Activity ◽  
Nanoparticle Drug Delivery ◽  
Anti Inflammatory
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