scholarly journals Confirmed case of Zika virus congenital infection, Spain, March 2016

2016 ◽  
Vol 21 (24) ◽  
Author(s):  
Sonia Perez ◽  
Ruben Tato ◽  
Jorge Julio Cabrera ◽  
Alberto Lopez ◽  
Olga Robles ◽  
...  
Keyword(s):  
Pregnant Woman ◽  
Amniotic Fluid ◽  
Brain Tissue ◽  
Umbilical Cord ◽  
Zika Virus ◽  
Congenital Infection ◽  
Arthrogryposis Multiplex Congenita ◽  
Ultrasound Scan ◽  
Imported Case ◽  
Fetal Malformations

We describe Zika virus (ZIKV) vertical transmission in an imported case in Spain, in a 17-week pregnant woman. ZIKV IgG, IgM and RNA were detected in serum in week 17. At 19 weeks, ultrasound scan revealed fetal malformations and ZIKV was detected in the amniotic fluid. Pregnancy was terminated at week 21; autopsy of the fetus revealed bilateral hydrocephalus, brain microcalcifications and arthrogryposis multiplex congenita. ZIKV was detected in the umbilical cord and brain tissue.

scholarly journals Zika virus detected in amniotic fluid and umbilical cord blood in an in vitro fertilization-conceived pregnancy in Venezuela

2017 ◽  
Vol 107 (6) ◽  
pp. 1319-1322 ◽  
Author(s):  
Isaac Benjamin ◽  
Gissel Fernández ◽  
José Valentin Figueira ◽  
Leticia Parpacén ◽  
María Teresa Urbina ◽  
...  
Keyword(s):  
In Vitro Fertilization ◽  
Amniotic Fluid ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Zika Virus ◽  
Vitro Fertilization

scholarly journals MSCs derived from amniotic fluid and umbilical cord require different administration schemes and exert different curative effects on different tissues in rats with CLP-induced sepsis

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Rui Chen ◽  
Yingjun Xie ◽  
Xuan Zhong ◽  
Fei Chen ◽  
Yu Gong ◽  
...  
Keyword(s):  
Survival Rate ◽  
Amniotic Fluid ◽  
Umbilical Cord ◽  
Proinflammatory Cytokine ◽  
Disease Model ◽  
Animal Experiments ◽  
Cytokine Levels ◽  
Liver And Kidney ◽  
Two Phases ◽  
Different Tissues

Abstract Background Mesenchymal stem cells (MSCs) are derived from multiple tissues, including amniotic fluid (AF-MSCs) and the umbilical cord (UC-MSCs). Although the therapeutic effect of MSCs on sepsis is already known, researchers have not determined whether the cells from different sources require different therapeutic schedules or exert different curative effects. We assessed the biofunction of the administration of AF-MSCs and UC-MSCs in rats with caecal ligation and puncture (CLP)-induced sepsis. Methods CLP was used to establish a disease model of sepsis in rats, and intravenous tail vein administration of AF-MSCs and UC-MSCs was performed to treat sepsis at 6 h after CLP. Two phases of animal experiments were implemented using MSCs harvested in saline with or without filtration. The curative effect was measured by determining the survival rate. Further effects were assessed by measuring proinflammatory cytokine levels, the plasma coagulation index, tissue histology and the pathology of the lung, liver and kidney. Results We generated rats with medium-grade sepsis with a 30–40% survival rate to study the curative effects of AF-MSCs and UC-MSCs. MSCs reversed CLP-induced changes in proinflammatory cytokine levels and coagulation activation. MSCs ameliorated CLP-induced histological and pathological changes in the lung, liver and kidney. AF-MSCs and UC-MSCs functioned differently in different tissues; UC-MSCs performed well in reducing the upregulation of inflammatory cytokine levels in the lungs and inhibiting the inflammatory cell infiltration into the liver capsule, while AF-MSCs performed well in inhibiting cell death in the kidneys and reducing the plasma blood urea nitrogen (BUN) level, an indicator of renal function. Conclusions Our studies suggest the safety and efficacy of AF-MSCs and UC-MSCs in the treatment of CLP-induced sepsis in rats and show that the cells potentially exert different curative effects on the main sepsis-affected tissues.

scholarly journals First Imported Case of Zika Virus Infection into Korea

2016 ◽  
Vol 31 (7) ◽  
pp. 1173 ◽  
Author(s):  
Hee-Chang Jang ◽  
Wan Beom Park ◽  
Uh Jin Kim ◽  
June Young Chun ◽  
Su-Jin Choi ◽  
...  
Keyword(s):  
Virus Infection ◽  
Zika Virus ◽  
Imported Case ◽  
Zika Virus Infection

scholarly journals Embryonic Stage of Congenital Zika Virus Infection Determines Fetal and Postnatal Outcomes in Mice

Viruses ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1807
Author(s):  
Eri Nakayama ◽  
Yasuhiro Kawai ◽  
Satoshi Taniguchi ◽  
Jessamine E. Hazlewood ◽  
Ken-ichi Shibasaki ◽  
...  
Keyword(s):  
Zika Virus ◽  
Neutralizing Antibodies ◽  
Neonatal Death ◽  
Motor Behavior ◽  
Wide Spectrum ◽  
Fetal Loss ◽  
Congenital Infection ◽  
Sensory Function ◽  
Zikv Infection ◽  
Wide Range

Zika virus (ZIKV) infection during pregnancy causes a wide spectrum of congenital abnormalities and postnatal developmental sequelae such as fetal loss, intrauterine growth restriction (IUGR), microcephaly, or motor and neurodevelopmental disorders. Here, we investigated whether a mouse pregnancy model recapitulated a wide range of symptoms after congenital ZIKV infection, and whether the embryonic age of congenital infection changed the fetal or postnatal outcomes. Infection with ZIKV strain PRVABC59 from embryonic day 6.5 (E6.5) to E8.5, corresponding to the mid-first trimester in humans, caused fetal death, fetal resorption, or severe IUGR, whereas infection from E9.5 to E14.5, corresponding to the late-first to second trimester in humans, caused stillbirth, neonatal death, microcephaly, and postnatal growth deficiency. Furthermore, 4-week-old offspring born to dams infected at E12.5 showed abnormalities in neuropsychiatric state, motor behavior, autonomic function, or reflex and sensory function. Thus, our model recapitulated the multiple symptoms seen in human cases, and the embryonic age of congenital infection was one of the determinant factors of offspring outcomes in mice. Furthermore, maternal neutralizing antibodies protected the offspring from neonatal death after congenital infection at E9.5, suggesting that neonatal death in our model could serve as criteria for screening of vaccine candidates.

scholarly journals Answer – Abortion and Zika Virus Congenital Infection

2018 ◽  
Vol 40 (08) ◽  
pp. 498-498
Author(s):  
Vivian Mota ◽  
Alanna Delfino ◽  
Thayse Lopes ◽  
André Pessoa ◽  
Erlane Ribeiro ◽  
...  
Keyword(s):  
Zika Virus ◽  
Congenital Infection
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