scholarly journals Outbreak of KPC-2-producing Klebsiella pneumoniae endowed with ceftazidime-avibactam resistance mediated through a VEB-1-mutant (VEB-25), Greece, September to October 2019

2020 ◽  
Vol 25 (3) ◽  
Author(s):  
Irene Galani ◽  
Ilias Karaiskos ◽  
Maria Souli ◽  
Vassiliki Papoutsaki ◽  
Lamprini Galani ◽  
...  
Keyword(s):  
Intensive Care ◽  
Klebsiella Pneumoniae ◽  
General Hospital ◽  
Intensive Care Units ◽  
Horizontal Transmission ◽  
Sequence Type ◽  
The Novel ◽  
Outbreak Strain ◽  
Extended Spectrum

From September to October 2019, seven patients colonised or infected with a ceftazidime-avibactam (CZA)-resistant Klebsiella pneumoniae carbapenemase (KPC)-2-producing K. pneumoniae were detected in two intensive care units of a Greek general hospital. The outbreak strain was sequence type (ST)147 and co-produced KPC-2 and the novel plasmid-borne Vietnamese extended-spectrum β-lactamase (VEB)-25 harbouring a K234R substitution associated with CZA resistance. Epidemiological investigations revealed that the resistance was probably acquired by horizontal transmission independently from previous CZA exposure.

Acquisition of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae in intensive care units in Thailand

2020 ◽  
Author(s):  
Kanit Assawatheptawee ◽  
Anong Kiddee ◽  
Anamai Na-udom ◽  
Apirath Wangteeraprasert ◽  
Pornpit Treebupachatsakul ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Intensive Care ◽  
Klebsiella Pneumoniae ◽  
Intensive Care Units ◽  
Extended Spectrum

scholarly journals Outbreak of CTX-M-15 Extended-Spectrum β-Lactamase-Producing Klebsiella pneumoniae ST394 in a French Intensive Care Unit Dedicated to COVID-19

Pathogens ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1426
Author(s):  
Cécile Emeraud ◽  
Samy Figueiredo ◽  
Rémy A. Bonnin ◽  
Mouna Khecharem ◽  
Souad Ouzani ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Klebsiella Pneumoniae ◽  
Intensive Care Units ◽  
Causative Agent ◽  
Nosocomial Outbreak ◽  
Extended Spectrum ◽  
Hygiene Measures ◽  
Cross Transmission

Infections caused by extended-spectrum β-lactamase-producing Klebsiella pneumoniae (ESBL-KP) are constantly rising worldwide and are often reported as causative agent of outbreaks in intensive care units (ICUs). During the first wave of the COVID-19 pandemic, bacterial cross-transmission was thought unlikely to occur due to the reinforcement of hygiene measures and prevention control. However, we report here an ESBL-producing K. pneumoniae (ST394) isolate responsible for a nosocomial outbreak in an ICU dedicated to COVID-19 patients.

scholarly journals KPC-2-producing Klebsiella pneumoniae ST11 in a Children’s Hospital in Poland

2017 ◽  
Vol 66 (3) ◽  
pp. 401-404 ◽  
Author(s):  
Monika Machulska ◽  
Anna Baraniak ◽  
Iwona Żak ◽  
Katarzyna Bojarska ◽  
Dorota Żabicka ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Intensive Care ◽  
Klebsiella Pneumoniae ◽  
Teaching Hospital ◽  
Sequence Type ◽  
Children's Hospital ◽  
Extended Spectrum ◽  
Children’S Hospital ◽  
Resistance Patterns ◽  
Pediatric Center

Four Klebsiella pneumoniae isolates from children hospitalized over 10 months in an intensive care unit in a children’s teaching hospital in Poland were analyzed. All of the isolates belonged to a single pulsotype and sequence type (ST) 11, and produced the KPC-2 carbapenemase and extended-spectrum β-lactamase (ESBL) CTX-M-15. They were resistant to a variety of antimicrobials, and their β-lactam resistance patterns were typical for KPC producers. This is one of few cases of identification of KPC (or carbapenemase)-producing K. pneumoniae in a pediatric center in Poland.

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