scholarly journals Waning antibody levels after COVID-19 vaccination with mRNA Comirnaty and inactivated CoronaVac vaccines in blood donors, Hong Kong, April 2020 to October 2021

2022 ◽  
Vol 27 (2) ◽  
Author(s):  
Shirley LL Kwok ◽  
Samuel MS Cheng ◽  
Jennifer NS Leung ◽  
Kathy Leung ◽  
Cheuk-Kwong Lee ◽  
...  
Keyword(s):  
Hong Kong ◽  
Vaccination Programme ◽  
Blood Donors ◽  
Inactivated Vaccine ◽  
Antibody Levels

The mRNA vaccine Comirnaty and the inactivated vaccine CoronaVac are both available in Hong Kong’s COVID-19 vaccination programme. We observed waning antibody levels in 850 fully vaccinated (at least 14 days passed after second dose) blood donors using ELISA and surrogate virus neutralisation test. The Comirnaty-vaccinated group’s (n = 593) antibody levels remained over the ELISA and sVNT positive cut-offs within the first 6 months. The CoronaVac-vaccinated group’s (n = 257) median antibody levels began to fall below the cut-offs 4 months after vaccination.

scholarly journals Waning antibody levels after vaccination with mRNA BNT162b2 and inactivated CoronaVac COVID-19 vaccines in Hong Kong blood donors

2021 ◽  
Author(s):  
Shirley LL Kwok ◽  
Samuel MS Cheng ◽  
Jennifer NS Leung ◽  
Kathy Leung ◽  
Cheuk-Kwong Lee ◽  
...  
Keyword(s):  
Hong Kong ◽  
Vaccination Programme ◽  
Blood Donors ◽  
Neutralization Test ◽  
Virus Neutralization Test ◽  
Virus Neutralization ◽  
Inactivated Vaccine ◽  
Immunosorbent Assays ◽  
Antibody Levels

AbstractBoth inactivated vaccine (CoronaVac; Sinovac) and mRNA vaccine (Comirnaty/BNT162b2; Fosun-Pharma/BioNTech) are available in Hong Kong’s COVID-19 Vaccination Programme. We reported waning antibody levels by enzyme-linked immunosorbent assays (ELISA) and surrogate virus neutralization test (sVNT) among 850 fully vaccinated blood donors (i.e., received two doses). The BNT162b2 group’s antibody levels remain over the 50% protection threshold within six months, and the CoronaVac’s group’s median antibody levels begin to fall below the 50% protection threshold two months after vaccination.

scholarly journals Evaluation of Vaccination Strategy Against Rabies in Hong Kong Macaques

2021 ◽  
Author(s):  
Omid Nekouei ◽  
Paolo Martelli ◽  
Sophie St-Hilaire ◽  
Hui Suk Wai ◽  
Karthiyani Krishnasamy ◽  
...  
Keyword(s):  
Hong Kong ◽  
Vaccination Strategy ◽  
Elisa Test ◽  
Enzyme Linked Immunosorbent Assay ◽  
Serological Response ◽  
Test Kit ◽  
In The Wild ◽  
The Government ◽  
Specific Association ◽  
Antibody Levels

Rabies is a fatal zoonotic disease that can affect all mammals. Following the directives of the rabies ordinance of the Government of Hong Kong, all wild macaques captured under an ongoing sterilization program (since 2000) were vaccinated against rabies. The main objective of this study was to assess the serological response to rabies vaccination in the population of Hong Kong macaques. An inactivated rabies vaccine was subcutaneously administered to captured macaques under anesthesia. In a 2015 field survey, blood samples from the animals were collected and stored in -80℃ freezer. In July 2021, all frozen sera from vaccinated animals were prepared and tested for antibodies against rabies virus using a commercial enzyme-linked immunosorbent assay (ELISA) test. The test results were dichotomized at the recommended cut-off point of the test kit. Sixty-five samples from the vaccinated macaques were available for this study. All of these animals had received at least one dose of vaccine (1 vaccination) between 2008 and 2015. The interval between the 1 vaccination and blood sampling dates ranged from 21 to 2,779 days. Only five of the 65 macaques had a second vaccination record at the time of sampling; all five had high antibody levels. Among the remaining macaques, 77% (46/60) were positive for rabies antibodies. No specific association was observed between the post-vaccination period and the antibody titer of these macaques and no adverse reactions to vaccination were reported. The current vaccination strategy in Hong Kong macaques appears to effectively elicit rabies antibodies in a high proportion of macaque populations in the wild (78-87%). However, reaching the precise level of protection against a potential challenge with the virus should further be investigated.

scholarly journals Evaluating impact of school outreach vaccination programme in Hong Kong influenza season 2018 – 2019

2019 ◽  
Vol 16 (4) ◽  
pp. 823-826 ◽  
Author(s):  
Yu Lung Lau ◽  
Wilfred Hing Sang Wong ◽  
Sonal R. Hattangdi-Haridas ◽  
Chun Bong Chow
Keyword(s):  
Hong Kong ◽  
Vaccination Programme ◽  
Influenza Season ◽  
School Outreach

Attitudes about organ and tissue donation among the general public and blood donors in Hong Kong

2001 ◽  
Vol 11 (2) ◽  
pp. 98-103 ◽  
Author(s):  
Philip Li ◽  
C. Lin ◽  
Peggo Lam ◽  
C. Szeto ◽  
Joseph Lau ◽  
...  
Keyword(s):  
Hong Kong ◽  
General Public ◽  
Blood Donors ◽  
Tissue Donation ◽  
Organ And Tissue Donation

scholarly journals LegionellaAntibodies in a Danish Hospital Staff with Known Occupational Exposure

2009 ◽  
Vol 2009 ◽  
pp. 1-6 ◽  
Author(s):  
M. Rudbeck ◽  
S. Viskum ◽  
K. Mølbak ◽  
S. A. Uldum
Keyword(s):  
Health Care ◽  
Blood Donors ◽  
Reference Group ◽  
Hospital Staff ◽  
Cross Sectional Study ◽  
Hospital Workers ◽  
Cross Sectional ◽  
Staff Members ◽  
Antibody Titres ◽  
Antibody Levels

Although legionnaires' disease frequently is acquired in health care institutions, little is known about the occupational risk ofLegionellainfection among health care workers. The aim of the present cross-sectional study was to analyse antibody levels among exposed hospital workers and to determine the correlation between antibodies toLegionellaand self-reported symptoms. The study included 258 hospital employees and a reference group of 708 healthy blood donors. Hospital workers had a higher prevalence ofLegionellaantibody titres (1 : 128) than blood donors (odds ratio 3.4; 95% CI 2.4–4.8). Antibody levels were not higher among staff members at risk of frequent aerosol exposure than among less exposed employees. There was no consistent association between a history of influenza-like symptom complex and the presence of antibodies. The results indicate that hospital workers have a higher risk ofLegionellainfections than the general population. However, since no excess morbidity was associated with seropositivity, mostLegionellainfections may be asymptomatic.

scholarly journals Cost-effectiveness of paediatric influenza vaccination in the Netherlands

2020 ◽  
Author(s):  
Pieter T. de Boer ◽  
Franklin C.K. Dolk ◽  
Lisa Nagy ◽  
Jan C. Wilschut ◽  
Richard Pitman ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Cost Saving ◽  
Influenza Vaccination ◽  
Vaccination Programme ◽  
Risk Groups ◽  
Inactivated Vaccine ◽  
Vaccination Strategies ◽  
Clinical Risk ◽  
Vaccine Type ◽  
Clinical Risk Groups

AbstractBackgroundThis study evaluates the cost-effectiveness of extending the Dutch influenza vaccination programme for elderly and clinical risk groups to include paediatric influenza vaccination, taking indirect protection into account.MethodsAn age-structured dynamic transmission model was used that was calibrated to influenza-associated GP visits over four seasons (2010/11 to 2013/14). The clinical and economic impact of different paediatric vaccination strategies were compared over 20 years, varying the targeted age range, the vaccine type for children and the vaccine type for elderly and clinical risk groups. Outcome measures include averted symptomatic infections and deaths, societal costs and quality-adjusted life years (QALYs), incremental cost-effectiveness ratios, and net health benefits (NHBs), using a willingness-to-pay threshold of €20,000 per QALY gained.ResultsAt an assumed coverage of 50%, adding vaccination of 2- to 17-year-olds with quadrivalent-live-attenuated influenza vaccine (Q-LAIV) to the current influenza vaccination programme was estimated to avert on average 406,270 symptomatic cases and 83 deaths per season compared to vaccination of elderly and risk groups with trivalent inactivated vaccine (TIV), and was cost-saving (cumulative 20-year savings of 36,396 QALYs and €1,680 million; NHB: 120,411 QALYs). This strategy dominated paediatric vaccination strategies targeting 2- to 6-year-olds or 2- to 12-year-olds, or paediatric vaccination strategies with TIV. The highest NHB was obtained when 2- to 17-year-olds were vaccinated with Q-LAIV and existing target groups switched from TIV to quadrivalent inactivated vaccine (NHB: 132,907 QALYs).ConclusionModelling indicates that paediatric influenza vaccination reduces the disease burden of influenza substantially and is cost-saving.

HIV-related behaviours among voluntary blood donors in Hong Kong

AIDS Care ◽  
2002 ◽  
Vol 14 (4) ◽  
pp. 481-492 ◽  
Author(s):  
J. T. F. Lau ◽  
J. Thomas ◽  
C. K. Lin
Keyword(s):  
Hong Kong ◽  
Blood Donors
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