scholarly journals Influenza A(H1N1)pdm09 antibodies after pandemic and trivalent seasonal influenza vaccination as well as natural infection in November 2010 in Hamburg, Germany

2012 ◽  
Vol 17 (2) ◽  
Author(s):  
J P Cramer ◽  
T Mac ◽  
B Hogan ◽  
S Stauga ◽  
S Eberhardt ◽  
...  
Keyword(s):  
Influenza Vaccination ◽  
Vaccination Coverage ◽  
Influenza A ◽  
Seasonal Influenza ◽  
Influenza Pandemic ◽  
Natural Infection ◽  
Haemagglutination Inhibition ◽  
Seasonal Influenza Vaccination ◽  
Influenza A H1n1 ◽  
Antibody Titres

The 2009 influenza pandemic has introduced the new re-assorted influenza A(H1N1)pdm09 virus which recirculated during the 2010/11 influenza season. Before that season, it was possible to acquire protective immunity either by pandemic or seasonal influenza vaccination against influenza A(H1N1)pdm09 or by natural infection. To obtain data on vaccination coverage and antibody levels in a reference population and to calculate whether or not the herd immunity threshold (HIT, calculated as 33% given an R0 of 1.5) was reached at the beginning of the 2010/11 season we performed a seroprevalence study in November 2010 in Hamburg, Germany. Antibody titres were assessed applying a haemagglutination inhibition test. Vaccination coverage was very low: 14% for pandemic and 11% for seasonal 2010/11 vaccinations. Even in those with underlying risk factors, vaccination coverage was not much higher: 17% for both vaccines. Serological analysis revealed antibody titres of ≥1:10 in 135 of 352 (38%) and of ≥1:40 in 61 of 352 study participants (17%). Specific antibodies were measurable in 26% of those without history of vaccination or natural infection, indicating a high proportion of subclinical and mild influenza disease. Nevertheless, the HIT was not reached, leaving the majority of the population susceptible to influenza A(H1N1)pdm09 and its potential complications.

scholarly journals Response to 2009 Pandemic Influenza A (H1N1) Vaccine in HIV-Infected Patients and the Influence of Prior Seasonal Influenza Vaccination

PLoS ONE ◽  
2011 ◽  
Vol 6 (1) ◽  
pp. e16496 ◽  
Author(s):  
Darius Soonawala ◽  
Guus F. Rimmelzwaan ◽  
Luc B. S. Gelinck ◽  
Leo G. Visser ◽  
Frank P. Kroon
Keyword(s):  
Influenza Vaccination ◽  
Pandemic Influenza ◽  
Influenza A ◽  
Seasonal Influenza ◽  
H1n1 Vaccine ◽  
Seasonal Influenza Vaccination ◽  
Influenza A H1n1

scholarly journals Effects of repeated vaccination and vaccine formulation on the induction of broadly neutralizing antibody responses against influenza A virus in children

2021 ◽  
Author(s):  
Sergey Yegorov ◽  
Daniel Celeste ◽  
Kimberly Braz Gomes ◽  
Jann C Ang ◽  
Colin Vandenhof ◽  
...  
Keyword(s):  
Influenza Vaccination ◽  
Neutralizing Antibodies ◽  
Influenza A ◽  
Seasonal Influenza ◽  
Natural Infection ◽  
Neutralizing Antibody ◽  
Seasonal Influenza Vaccination ◽  
Vaccine Type ◽  
Paediatric Cohort ◽  
The Impact

The induction of broadly neutralizing antibodies (bNAbs) that target the hemagglutinin stalk domain is a promising strategy for the development of universal influenza virus vaccines. bNAbs can be boosted in adults by sequential exposure to heterosubtypic viruses through natural infection or vaccination. However, little is known about if/how bNAbs are induced by vaccination in more immunologically naive children. Here, we describe the impact of repeated seasonal influenza vaccination and vaccine type on induction of bNAbs in a well-characterized paediatric cohort enrolled in a series of randomized control trials of seasonal influenza vaccination. Repeated seasonal vaccination resulted in significant boosting of a durable bNAb response. Boosting of serological bNAbs titers was comparable within inactivated and live attenuated (LAIV) vaccinees and declined with age. These data provide new insights into vaccine-elicited bNAb induction in children, which has important implications for the design of universal influenza vaccine modalities in this critical population.

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