Investigation of the relationship of corneal densitometry, corneal volume and central corneal thickness with age in healthy individuals

AIMSTo evaluate the contrast sensitivity in patients with nuclear cataract and corneal guttae compared to patients with nuclear cataract without guttae.METHODSIn this retrospective, single-centre case series, 50 eyes of 50 patients fulfilling the inclusion criteria were enrolled. Patients with corneal guttae and nuclear cataract (n=25, study group) underwent triple Descemet membrane endothelial keratoplasty (DMEK). Patients with nuclear cataract and healthy corneas underwent cataract surgery (n=25, control group). Inclusion criteria were preoperative best-corrected visual acuity ≥20/40, no corneal oedema and similar lens opacity (nuclear opalescence 2.0–2.9). Outcome measures included MARS letter and OPTEC 6500P contrast sensitivity test, corneal volume, central corneal thickness and anterior and posterior corneal densitometry.RESULTSPreoperative MARS letter and OPTEC 6500P contrast sensitivity was significantly worse in the study group (MARS: p<0.001; OPTEC 6500P: p<0.007 at low spatial frequencies in daylight with and without glare and nightlight without glare). After surgery, there was no significant difference in MARS letter contrast sensitivity between groups (p=0.225). OPTEC 6500P contrast sensitivity remained significantly lower in the study group in daylight and nightlight with and without glare at most spatial frequencies (p<0.01) postoperatively. Preoperative and postoperative corneal volume, central corneal thickness and anterior corneal densitometry were equal in both groups (p>0.05). Posterior densitometry was significantly higher in the study group than in the control group preoperatively (p<0.001) but turned into equal values postoperatively (p=0.07).CONCLUSIONSCorneal guttae cause an additional significant decrease in contrast sensitivity in eyes with nuclear cataract. This is in favour of performing a triple DMEK even in eyes with a visual acuity of ≥20/40.

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The relationship of Central Corneal Thickness (CCT) to Thinnest Central Cornea (TCC) in healthy adults

Contact Lens and Anterior Eye ◽

10.1016/j.clae.2008.07.006 ◽

2009 ◽

Vol 32 (2) ◽

pp. 64-67 ◽

Cited By ~ 25

Author(s):

Pammal T. Ashwin ◽

Sunil Shah ◽

Sreekumari Pushpoth ◽

Louai Wehbeh ◽

Balasubramaniam Ilango

Keyword(s):

Central Corneal Thickness ◽

Corneal Thickness ◽

Healthy Adults ◽

Central Cornea ◽

Relationship Of ◽

The Relationship

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Refractive outcome and tomographic changes after Descemet membrane endothelial keratoplasty in pseudophakic eyes with Fuchs’ endothelial dystrophy

International Ophthalmology ◽

10.1007/s10792-021-01850-w ◽

2021 ◽

Author(s):

Bishr Agha ◽

Nura Ahmad ◽

Daniel G. Dawson ◽

Thomas Kohnen ◽

Ingo Schmack

Keyword(s):

Central Corneal Thickness ◽

Corneal Thickness ◽

Corneal Astigmatism ◽

Endothelial Keratoplasty ◽

Descemet Membrane Endothelial Keratoplasty ◽

Corneal Densitometry ◽

Scheimpflug Imaging ◽

Fuchs Endothelial Dystrophy ◽

Posterior Corneal Astigmatism

Abstract Purpose To analyze refractive and topographic changes secondary to Descemet membrane endothelial keratoplasty (DMEK) in pseudophakic eyes with Fuchs’ endothelial dystrophy (FED). Methods Eighty-seven pseudophakic eyes of 74 patients who underwent subsequent DMEK surgery for corneal endothelial decompensation and associated visual impairment were included. Median post-operative follow-up time was 12 months (range: 3–26 months). Main outcome measures were pre- and post-operative manifest refraction, anterior and posterior corneal astigmatism, simulated keratometry (CASimK) and Q value obtained by Scheimpflug imaging. Secondary outcome measures included corrected distance visual acuity (CDVA), central corneal densitometry, central corneal thickness, corneal volume (CV), anterior chamber volume (ACV) and anterior chamber depth (ACD). Results After DMEK surgery, mean pre-operative spherical equivalent (± SD) changed from + 0.04 ± 1.73 D to + 0.37 ± 1.30 D post-operatively (p = 0.06). CDVA, proportion of emmetropic eyes, ACV and ACD increased significantly during follow-up. There was also a significant decrease in posterior corneal astigmatism, central corneal densitometry, central corneal thickness and corneal volume over time (p = 0.001). Only anterior corneal astigmatism and simulated keratometry (CASimK) remained fairly stable after DMEK. Conclusion Despite tendencies toward a hyperopic shift, changes in SE were not significant and refraction remained overall stable in pseudophakic patients undergoing DMEK for FED. Analysis of corneal parameters by Scheimpflug imaging mainly revealed changes in posterior corneal astigmatism pointing out the relevance of posterior corneal profile changes during edema resolution after DMEK.

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Correlation of central corneal thickness and axial length to the optic disc and peripapillary atrophy among healthy individuals, glaucoma and ocular hypertension patients

Clinical Ophthalmology ◽

10.2147/opth.s4293 ◽

2008 ◽

pp. 981 ◽

Cited By ~ 8

Author(s):

George Tomais

Keyword(s):

Ocular Hypertension ◽

Optic Disc ◽

Axial Length ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Healthy Individuals ◽

Peripapillary Atrophy

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1987 The Relationship between Central Corneal Thickness, Tonographic Outflow Facility, and Intraocular Pressure

SciVee ◽

10.4016/40509.01 ◽

2012 ◽

Author(s):

Pouya Alaghband ◽

Evgenia Kanonidou ◽

Laura Beltran-Agullo ◽

Darryl R. Overby ◽

K Sheng Lim

Keyword(s):

Intraocular Pressure ◽

Central Corneal Thickness ◽

Corneal Thickness ◽

Outflow Facility ◽

The Relationship

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Relationship between novel intraocular pressure measurement from Corvis ST and central corneal thickness and corneal hysteresis

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2019-314370 ◽

2019 ◽

Vol 104 (4) ◽

pp. 563-568 ◽

Cited By ~ 2

Author(s):

Masato Matsuura ◽

Hiroshi Murata ◽

Yuri Fujino ◽

Mieko Yanagisawa ◽

Yoshitaka Nakao ◽

...

Keyword(s):

Intraocular Pressure ◽

Central Corneal Thickness ◽

Linear Regression Analysis ◽

Corneal Thickness ◽

Biomechanical Properties ◽

Applanation Tonometry ◽

Corneal Hysteresis ◽

Corneal Resistance Factor ◽

Corvis St ◽

The Relationship

AimsCorvis ST (CST) yields biomechanical corrected IOP (bIOP) which is purported to be less dependent on biomechanical properties. In our accompanied paper, it was suggested that the repeatability of bIOP is high. The purpose of the current study was to assess the relationship between intraocular pressure (IOP) measured with CST and central corneal thickness (CCT) and corneal hysteresis (CH), in comparison with IOP measured with Goldmann applanation tonometry (GAT) and the ocular response analyzer (ORA).MethodsA total of 141 eyes from 141 subjects (35 healthy eyes and 106 glaucomatous eyes) underwent IOP measurements with GAT, CST and ORA. The relationships between IOP measurements (ORA-IOPg, ORA-IOPcc, CST-bIOP and GAT IOP) and biomechanical properties (CCT, CH and corneal resistance factor (CRF)) were analysed using the linear regression analysis.ResultsIOPg, IOPcc and GAT IOP were significantly associated with CCT (p<0.001), whereas bIOP was not significantly associated with CCT (p=0.19). IOPg, bIOP and GAT IOP were significantly associated with CH (IOPg: p<0.001; bIOP: p<0.001; GAT IOP: p=0.0054), whereas IOPcc was not significantly associated with CH (p=0.18). All of IOP records were associated with CRF (p<0.001).ConclusionThe bIOP measurement from CST is independent from CCT, but dependent on CH and CRF.

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The Effect of Corneal Thickness, Densitometry and Curvature on Intraocular Pressure Measurements Obtained by Applanation, Rebound and Dynamic Contour Tonometry

Vision ◽

10.3390/vision4040045 ◽

2020 ◽

Vol 4 (4) ◽

pp. 45

Author(s):

Marco Antonio de Castro Olyntho Junior ◽

Lucas Bertazzi Augusto ◽

Carolina P. B. Gracitelli ◽

Andrew J. Tatham

Keyword(s):

Intraocular Pressure ◽

Prospective Study ◽

Corneal Thickness ◽

Applanation Tonometry ◽

Corneal Astigmatism ◽

Dynamic Contour Tonometry ◽

Pressure Measurements ◽

Cross Sectional ◽

Corneal Densitometry ◽

The Relationship

Evaluate the effect of corneal thickness, densitometry and curvature on intraocular pressure (IOP) measurements obtained by Goldmann applanation tonometry (GAT), non-contact tonometry (NCT), rebound tonometry (RT), and dynamic contour tonometry (DCT). A cross-sectional prospective study involving 40 participants was performed. Corneal measurements were obtained using Pentacam (Oculus GMbH, Wetzlar, Germany), densitometry was measured at annuli of 0–2, 2–6, 6–10 and 10–12 mm. The relationship between corneal thickness (central, 4 and 6 mm), corneal astigmatism and corneal densitometry and IOP was examined. There was a significant relationship between corneal thickness (central, 4 and 6 mm) and GAT180, GAT90, RT, and NCT (P < 0.001 for all comparisons) but not for DCT. Higher corneal densitometry (6–10 mm and 10–12 mm zones) was associated with higher IOP from GAT180 and GAT90, and higher densitometry in the 6–10 mm zone correlated with higher IOP from NCT, however corneal densitometry increased with age. Accounting for age, the relationship between corneal densitometry and IOP measurements was not significant. In eyes with greater corneal astigmatism there was a greater difference between GAT90 and GAT180 measurements. IOP measurements may be affected by corneal thickness, densitometry and curvature. DCT was less affected by properties of the cornea compared to other devices.

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