scholarly journals Histological investigation of the protective effect of metformin on testis and sperm parameters in obese rats with type 2 diabetes mellitus

2021 ◽  
Vol 5 (9) ◽  
pp. 954-959
Author(s):  
Özcan BUDAK
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Protective Effect ◽  
Sperm Parameters ◽  
Histological Investigation ◽  
Obese Rats

scholarly journals Fecal microbiota transplantation alters the susceptibility of obese rats to type 2 diabetes mellitus

Aging ◽  
2020 ◽  
Vol 12 (17) ◽  
pp. 17480-17502
Author(s):  
Lijing Zhang ◽  
Wen Zhou ◽  
Libin Zhan ◽  
Shenglin Hou ◽  
Chunyan Zhao ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Fecal Microbiota Transplantation ◽  
Fecal Microbiota ◽  
Obese Rats

scholarly journals TGF-β1 Gene Polymorphism in Codon 10 +869*C/T and Codon 25 +915*G/C Positions in Iraqi Patients with Type 2 Diabetes Mellitus

2016 ◽  
Vol 10 (2) ◽  
pp. 47-51
Author(s):  
Ihsan A. Hussein
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Protective Effect ◽  
Control Sample ◽  
Amplification Refractory Mutation System ◽  
Blood Samples ◽  
Increased Risk ◽  
Tgf Β1

This study included 50 blood samples that were collected from patients with age ranged between 35-65 years. Thirty samples were collected from patients with Type 2 Diabetes Mellitus (T2DM), while 20 blood samples were collected from healthy individuals as a control sample. The polymorphism results of TGF-β1 gene in codon 10: +869*C/T position by using amplification refractory mutation system (ARMS-PCR) showed that the T allele was suggested to have a protective effect, while C allele was associated with an increased risk of T2DM. The TT and CT were suggested to have a protective effect, while CC genotype was associated with an increased risk of T2DM. The polymorphism results of TGF-β1 gene in codon 25: +915*G/C position in samples showed that the G allele was suggested to have a protective effect, while C allele was associated with an increased risk of T2DM. The GC genotype was suggested to have a protective effect, while GG and CC genotypes were associated with an increased risk of T2DM.

scholarly journals Impact of Bariatric Surgery on Ghrelin and Obestatin Levels in Obesity or Type 2 Diabetes Mellitus Rat Model

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Donglei Zhou ◽  
Xun Jiang ◽  
Weixing Ding ◽  
Dingyu Zhang ◽  
Lei Yang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Bariatric Surgery ◽  
Type 2 Diabetes Mellitus ◽  
Weight Control ◽  
Sham Operation ◽  
Gk Rats ◽  
Obese Rats ◽  
To Receive

We aimed to evaluate the therapeutic efficacy on weight control by different bariatric surgeries and investigate the ghrelin and obestatin changes after these surgeries in obesity and nonobese type 2 diabetes mellitus (T2DM) rats. Obese rats were randomly assigned to receive sleeve gastrectomy (SG,n=8), minigastric bypass (MGBP,n=8), roux-en-Y gastric bypass (RYGBP,n=8), and sham operation (SO,n=4). Another 4 rats served as control. Besides, Goto-Kakisaki (GK) rats were also randomly divided into similar groups except for total gastrectomy (TG,n=8) group. The results showed that in obese rats, weigh loss in RYGBP group was similar to that in MGBP group but larger than that in SG group. Ghrelin significantly increased in RYGB group, but obestatin increased in MGBP group. Ghrelin/obestatin ratio significantly decreased in SG group. In GK rats, weight loss was most obvious in TG group. Postoperatively, ghrelin was significantly increased in MGBP and RYGB groups but decreased in TG group. Obestatin also showed an increase in MGBP and RYGB groups. Ghrelin/obestatin in TG group decreased significantly. In conclusion, RYGB and MGBP may be more suitable for obese rats, but TG may be the best strategy for T2DM rats to control weight with different mechanisms.

scholarly journals ENDOTHELIAL PROTECTIVE EFFECT OF LIRAGLUTIDE IN TYPE 2 DIABETES MELLITUS

2018 ◽  
Vol 24 (1) ◽  
pp. 81-92 ◽  
Author(s):  
A. V. Simanenkova ◽  
M. N. Makarova ◽  
M. I. Butomo ◽  
T. D. Vlasov ◽  
E. V. Shlyakhto
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Protective Effect

scholarly journals Protective effect against type 2 diabetes mellitus identified within the ACDC gene in a black South African diabetic cohort

Metabolism ◽  
2007 ◽  
Vol 56 (5) ◽  
pp. 587-592 ◽  
Author(s):  
Antonel Olckers ◽  
G. Wayne Towers ◽  
Annelize van der Merwe ◽  
Peter E.H. Schwarz ◽  
Paul Rheeder ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Protective Effect ◽  
South African ◽  
Black South African
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