Kidney damage in Covid-19: clinical and morphological manifestations of renal pathology in 220 patients died from Covid-19

2020 ◽  
Vol 22 (Special_Issue) ◽  
pp. 46-55
Author(s):  
E.S. Stolyarevich ◽  
◽  
N.F. Frolova ◽  
L.Y. Artyukhina ◽  
V.V. Varyasin ◽  
...  
Keyword(s):  
Kidney Damage ◽  
Renal Pathology

scholarly journals The correlation between the level of secretion and the type of monoclonal paraprotein and kidney damage in lymphoproliferative disorders

2019 ◽  
Vol 1 (1) ◽  
pp. 31-40
Author(s):  
Olga Pisarevskaya ◽  
Aleksandra Kotelnikova ◽  
Sergey Kazakov ◽  
Nikolay Potekhin ◽  
Oleg Rukavicyn
Keyword(s):  
Renal Failure ◽  
Stage Iv ◽  
Kidney Damage ◽  
Renal Pathology ◽  
Stage Iii ◽  
Structural Components ◽  
Lymphoproliferative Diseases ◽  
Number Of Patients ◽  
Monoclonal Proteins

Introduction. The course of lymphoproliferative diseases accompanied by the secretion of paraproteins is complicated by damage to the kidneys and the development of renal failure. There is a pathogenetic relationship between the physicochemical properties of monoclonal proteins and renal pathology. Objective: to find out the relationship between the type of monoclonal paraprotein, the level of its secretion and the degree of renal failure in lymphoproliferative diseases. Patients and methods. We analyzed 108 patients with lymphoproliferative diseases in whom secretion of paraprotein was detected. Age from 31 to 86 years (median 62.5 years). Chronic kidney disease (CKD) was diagnosed in 78 out of 108 patients. Results. CKD was diagnosed in patients with multiple myeloma. Stage III CKD was diagnosed in 28 (35.9%) patients, stage IV - in 14 (17.9%), stage V - in 19 (24.4%). 91 patients were diagnosed with concomitant diseases predisposing to the development of renal pathology. In the blood serum of patients with paraproteinemic hemoblastosis in combination with CKD, the vast majority were patients with the secretion of Gκ and Gλ paraproteins, free light chains (FLC). In a significant number of patients, Bens-Jones protein (BJ) in urine was determined. Less commonly, the secretion of paraproteins Dλ, Aλ, Aκ and Mκ was determined. The highest level of pathological proteins of all classes and their structural components and fragments was observed in patients with stage III CKD. A negative correlation of glomerular filtration rate (GFR) with FLCκ in the blood (r = –0.21), GFR with BJκ (r = –0.35), GFR with FLCλ in the blood (r = –0.13), GFR c BJλ, which indicates a tendency to damage the kidneys of FLC and protein BJ. Conclusion. In patients with lymphoproliferative diseases accompanied by monoclonal secretion of paraprotein and kidney damage with the development of CKD, in most cases the blood paraproteins Gκ, Gλ, FLCκ and FLCλ as well as protein BJ in urine, were determined. Paraproteins Aκ, Aλ, Mκ, Mλ, Dλ were determined much less frequently in serum. The highest level of pathological Ig and their structural components was observed in patients with stage III CKD. No association with quantitative level, type of paraprotein, and kidney damage was found. The role of FLC and BJ protein in the development of nephropathy has been confirmed.

scholarly journals Features of the course of hemorrhagic fever with renal syndrome in HIV-infected patients

2021 ◽  
Vol 11 (5) ◽  
pp. 951-957
Author(s):  
K. M. Manakhov ◽  
E. V. Povysheva ◽  
A. R. Gilyazova ◽  
D. S. Sarksyan
Keyword(s):  
Hiv Infection ◽  
Rating Scale ◽  
Hemorrhagic Fever ◽  
Developed Countries ◽  
Kidney Damage ◽  
Renal Pathology ◽  
Lumbar Region ◽  
Mild Disease ◽  
Group 2 ◽  
Group 1

Human immunodeficiency virus (HIV) is a significant medical and social problem for many developed countries. HIV infection is featured with developing chronic kidney pathology as well as acute renal damage. In some regions, hemorrhagic fever with renal syndrome (HFRS) can contribute somehow to developing renal pathology in HIVinfected subjects. The aim of the study was to identify clinical and laboratory features of HFRS course during HIV infection. A retrospective study was conducted by forming two groups: group 1 consisted of 9 patients suffered from HFRS together with verified HIV infection, group 2 — 53 patients with HFRS but lacking any clinical and epidemiological indications supporting HIV infection. Subjects in both groups were age- and sex-matched. The average age of the patients in group 1 and group 2 was 34 and 31 years, respectively. For statistical analysis, the licensed SPSS 22.0 software was used. A significance level p for statistical criteria was set equal to 0.05. In general, HFRS course in all patients was accompanied by characteristic signs: intoxication syndrome, impaired vision, hemorrhagic rash, pain in the lumbar region, decreased diuresis, thrombocytopenia, proteinuria, polymorphic urinary syndrome and azotemia. HFRS patients with concomitant HIV infection often complain of dry mouth, bloating, visible shortness of breath. Laboratory changes describe more severe kidney damage. A direct strong correlation was shown between leukocyte count and level of blood urea in patients with concomitant HIV infection (r = 0.798; p = 0.01). The combination of HFRS and HIV was accompanied by a milder HFRS course — rate of mild disease was almost 6-fold higher among patients of this group. In this case, no cases of severe hemorrhagic fever with renal syndrome combined with HIV were noted. Our study allowed to obtain unambiguous data. Predisposition of HIV-infected patients to renal pathology may be a determining factor in kidney damage upon emerging HFRS: more prominent rise in creatinine and urea level. Moreover, according to rating scale for assessing HFRS severity, it formally turned out that during concomitant HIV infection patients more often fit to a mild disease severity, even in the presence of more pronounced renal manifestations. The occurrence of acute renal pathology in HIV-infected patients is a life-threatening condition, a factor of deterioration of chronic renal pathology and a predictor of death. Consequently, this patient population requires thorough monitoring both at inpatient and outpatient stages.

491-P: Obesity-Induced Kidney Damage Is Attenuated by Genetic Deletion of miR-379 in Mice

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 491-P
Author(s):  
MARYAM ABDOLLAHI ◽  
MITSUO KATO ◽  
RAGADEEPTHI TUNDUGURU ◽  
LINDA L. LANTING ◽  
RAMA NATARAJAN
Keyword(s):  
Kidney Damage ◽  
Genetic Deletion

Liver, Kidney Function Tests and Oxidative Damage During and after Treatment of Salmonella typhimurium Infection in Experimental Local Rabbits

2018 ◽  
Vol 9 (4) ◽  
Author(s):  
Mustafa Salah Hasan ◽  
Ayman Barzan Abdulgafor ◽  
Maher Saber Owain ◽  
Mohammed Ali Hussein ◽  
Qusay Mohammed Aboud ◽  
...  
Keyword(s):  
Single Dose ◽  
Oxidative Damage ◽  
Salmonella Typhimurium ◽  
Infected Group ◽  
Post Treatment ◽  
Kidney Damage ◽  
Control Group ◽  
Post Inoculation ◽  
Group 5 ◽  
Group 2

This study aimed to evaluate the liver, kidney damage caused by S. typhimurium and to estimate the oxidative damage in association with this bacteria. A highly virulent isolates of S. typhimurium were obtained from the department of internal and preventive medicine/ College of Veterinary Medicine/ University of Baghdad. A twenty five local rabbits of both genders with age range (2-4 months) weeks old were used for this study, the rabbits were divided randomly into five groups each group contains 5 rabbits :- group 1: drenched orally with 5 ml of normal saline and consider as control group, group 2: were drenched orally with (5 ml) suspension which contain (5��109 CFU) of Salmonella typhimurium and regarded as infected group, group 3 were drenched orally with (5 ml) suspension which have (5��109 CFU) of Salmonella typhimurium then treated with a single dose of gentamicin alone at 0.05ml/kg (5mg/ml) orally after presence of signs (after 24hrs. post inoculation), group 4 were drenched (5 ml) suspension having (5��109 CFU) of Salmonella typhimurium then treated with a single dose of Ca-EDTA alone at 40mg/kg orally after presence of signs (after 24hrs. post inoculation) and group 5 were drenched (5 ml) suspension that contain (5��109 CFU) of Salmonella typhimurium then treated with a single dose of combined gentamicin at 0.05ml/kg (5mg/ml) orally after presence of signs (after 24hrs. post inoculation) and Ca-EDTA 40mg/kg after presence of signs (after 24hrs. post inoculation).The results of biochemical profile showed a significant increase (p less than 0.05) in ALT, creatinine and urea levels in infected group as compared with control group, while, the treated groups especially group 5 showed a significant improvement in ALT, Urea and creatinine levels which returned to relative normal levels as compared with infected group after 96hrs. post treatment. Also, the results of oxidative stress showed a significant increase in the levels of MDA in G2, G3, G4 and G5 after 48 hrs. post treatment, while the level of GSH showed a significant decrease in the level at 48hrs., both were returned to relative normal levels after 96hrs.post treatment especially in group 5.In conclusion, S. typhimurium can causing liver and kidney damage which is manifested by increase ALT, Urea and Creatinine. Also, MDA and GSH is increased due to salmonellosis.

Diagnostics of kidney damage in the medium and large vessels vasculitis - review and presentation of three cases

2020 ◽  
Vol 22 (1) ◽  
pp. 108-130
Author(s):  
E.V. Zakharova ◽  
◽  
T.A. Makarova ◽  
E.S. Leonova ◽  
E.S. Stolyarevich ◽  
...  
Keyword(s):  
Kidney Damage ◽  
Large Vessels

Content of inositolphosphates in blood and urine is a marker of renal pathology

2017 ◽  
Vol 2017 (1) ◽  
pp. 58-61
Author(s):  
I. V. Sorokina ◽  
◽  
I. V. Borzenkova ◽  
M. S. Myroshnychenko ◽  
O. M. Pliten ◽  
...  
Keyword(s):  
Renal Pathology

Renal Pathology in Wagr Syndrome

1996 ◽  
Vol 16 (6) ◽  
pp. 1013-1021 ◽  
Author(s):  
Ilana Ariel ◽  
Dvorah Abeliovich ◽  
Jacob Bar-Ziv ◽  
Abraham Hochberg
Keyword(s):  
Renal Pathology ◽  
Wagr Syndrome

Characteristics of the course of nephritis associated with Iga-vasculitis Henoch-Schoenlein in children

2020 ◽  
Vol 24 (3) ◽  
pp. 64-71
Author(s):  
A. V. Sukalo ◽  
I. A. Kazyra
Keyword(s):  
Clinical Laboratory ◽  
Morphological Changes ◽  
Pediatric Nephrology ◽  
Morphological Characteristics ◽  
Lymphocyte Activation ◽  
Renal Tissue ◽  
Kidney Damage ◽  
Iga Vasculitis ◽  
Factors Affecting ◽  
Treatment Regimens

INTRODUCTION. Among systemic vasopathies in children, IgA vasculitis Henoch Schoenlein (HS) is the most common, according to various authors, kidney damage is noted in 25-80 % and usually determines the prognosis of the disease.THE AIM of the study was to analyze clinical, laboratory, immunological, morphological characteristics, features of the course and treatment of nephritis associated with IgA vasculitis HS in children, as well as factors affecting the prognosis.PATIENTS AND METHODS. The study included 31 patients with morphologically verified nephritis due to IgA vasculitis HS (18 – boys, 13 – girls) aged 3 to 17 years, who were monitored at the Nephrology Department of the "2nd Children's City Clinical Hospital" of the National Center for Pediatric Nephrology and Renal Replacement therapy in Minsk from 2010 to 2019 yrs.The following parameters were analyzed: the clinical variant of kidney damage, laboratory tests (including the study of BAFF, RANTES lymphocyte activation molecules, pro-inflammatory IL1β, caspase1, TNFα, growth factors VEGF, TGF), 24 hours monitoring and office blood pressure measurements, ECHO cardiography with indicescalculation, ultrasound of the carotid arteries with the thickness of intima-media complex, morphological changes in the renal tissue, as well as treatment regimens.RESULTS. The contribution of deGal-IgA1, markers of T and B lymphocytes activation, pro-inflammatory and profibrotic molecules in the development of the disease is shown. Arterial hypertension was registered in 42 % of children, signs of heart remodeling according to the calculated indices in 19,3 %. Decrease level of adiponectin, vitamin D, leptin, increase concentration of obestatin, Pro-BNP, hs-CRP, and TSAT indicator classify patients with nephritis due to IgA vasculitis HS at moderate risk for the developmentof cardio-vascular disorders, which suggests the need for timely correction.CONCLUSION. In most cases, nephritis with IgA vasculitis HS has a benign course with rare relapses and progression to the end stage of chronic kidney disease (6,5 %).

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