Synthesis and properties of esters and amides of pyridine- and 1,2-azolcarbonic acids
2021 ◽
Vol 57
(2)
◽
pp. 185-194
Based on esters of nicotinic and isonicotinic acids with hydroxybenzaldehydes, a series of functionally substituted derivatives containing isoxazole and isothiazole heterocycles in the molecule have been synthesized. Azomethines were obtained by condensation of nicotinates and isonicotinates with p-bromoaniline and m-aminophenol, which have been reduced with sodium triacetoxyborohydride to give the corresponding amines. Acylation of amino derivatives of nicotinates and isonicotinates with 5-arylisoxazole- and 4,5-dichloroisothiazolecarbonyl chlorides leads to the esters and amides with isoxazole and isothiazole residues.
2019 ◽
Vol 19
(13)
◽
pp. 1093-1110
◽
1973 ◽
Vol 22
(5)
◽
pp. 1077-1082
2007 ◽
Vol 2007
(25)
◽
pp. 4257-4266
◽
1989 ◽
Vol 42
(11)
◽
pp. 1673-1683
◽
1945 ◽
Vol 67
(6)
◽
pp. 1017-1020
◽
2007 ◽
Vol 182
(3)
◽
pp. 677-686
◽
Keyword(s):