scholarly journals Complement Factor (C3) Level as Marker of Inflammation in Paediatric Asthma

2019 ◽  
Vol 3 (2) ◽  
pp. 36-38
Author(s):  
AR Somashekar ◽  
KG Ramakrishnan ◽  
Vanitha Gowda
Keyword(s):  
Complement Factor ◽  
Paediatric Asthma ◽  
Complement Factor C3

scholarly journals Evidence for non-traditional activation of complement factor C3 during murine liver regeneration

2008 ◽  
Vol 45 (11) ◽  
pp. 3125-3132 ◽  
Author(s):  
Amelia Clark ◽  
Alexander Weymann ◽  
Eric Hartman ◽  
Yumirle Turmelle ◽  
Michael Carroll ◽  
...  
Keyword(s):  
Liver Regeneration ◽  
Complement Factor ◽  
Murine Liver ◽  
Complement Factor C3

A case of Graves’ disease associated with membranoproliferative glomerulonephritis and leukocytoclastic vasculitis

2018 ◽  
Vol 31 (10) ◽  
pp. 1165-1168 ◽  
Author(s):  
Werner Keenswijk ◽  
Eva Degraeuwe ◽  
Anne Hoorens ◽  
Jo Van Dorpe ◽  
Johan Vande Walle
Keyword(s):  
Renal Function ◽  
Membranoproliferative Glomerulonephritis ◽  
Leukocytoclastic Vasculitis ◽  
White Cell Count ◽  
Gastrointestinal Symptoms ◽  
Thyroid Stimulating Hormone ◽  
Graves Disease ◽  
Complement Factor ◽  
Gradual Improvement ◽  
Complement Factor C3

Abstract Background The association of hyperthyroidism with renal disease is very rare and the importance of timely clinical recognition cannot be overemphasized. Case presentation An 11-year-old girl presented with gastrointestinal symptoms while hypertension, edema and abdominal pain were noticed on clinical examination. Laboratory investigation revealed: hemoglobin 9.4 (11.5–15.5) g/dL, total white cell count 16 (4.5–12)×109/L, platelets 247 (150–450)×109/L, C-reactive protein (CRP) 31.8 (<5) mg/L, blood urea nitrogen (BUN) 126 (13–43) mg/dL, creatinine 0.98 (0.53–0.79) mg/dL, albumin 25 (35–52) g/dL, complement factor C3 0.7 (0.9–1.8) g/L, complement factor C4 0.1 (0.1–0.4) g/L, tri-iodothyronine 6.5 (2.5–5.2) pg/mL, free thyroxine 2.4 (1–1.7) ng/dL, thyroid stimulating hormone (TSH) <0.02 (0.5–4.3) mU/L. Urinalysis showed nephrotic range proteinuria. Renal function deteriorated necessitating hemodialysis (HD). A renal biopsy revealed an immune complex-mediated membranoproliferative glomerulonephritis (MPGN). Elevated thyroid hormones and suppressed TSH levels with elevated thyroperoxidase antibodies and thyroid stimulating immunoglobulins confirmed the diagnosis of Graves’ disease. Corticosteroids were commenced and eventually thiamazole was added with gradual improvement of renal function, cessation of HD and discharge from the hospital. Conclusions Graves’ disease complicated by MPGN is extremely rare, but can cause life-threatening complications.

scholarly journals Discrete viral E2 lysine residues and scavenger receptor MARCO are required for clearance of circulating alphaviruses

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Kathryn S Carpentier ◽  
Bennett J Davenport ◽  
Kelsey C Haist ◽  
Mary K McCarthy ◽  
Nicholas A May ◽  
...  
Keyword(s):  
Disease Severity ◽  
Mutational Analysis ◽  
Scavenger Receptor ◽  
Transmission Efficiency ◽  
Complement Factor ◽  
Critical Determinant ◽  
Lysine Residues ◽  
Complement Factor C3 ◽  
Immune Pathway ◽  
Innate Immune Pathway

The magnitude and duration of vertebrate viremia is a critical determinant of arbovirus transmission, geographic spread, and disease severity. We find that multiple alphaviruses, including chikungunya (CHIKV), Ross River (RRV), and o’nyong ‘nyong (ONNV) viruses, are cleared from the circulation of mice by liver Kupffer cells, impeding viral dissemination. Clearance from the circulation was independent of natural antibodies or complement factor C3, and instead relied on scavenger receptor SR-A6 (MARCO). Remarkably, lysine to arginine substitutions at distinct residues within the E2 glycoproteins of CHIKV and ONNV (E2 K200R) as well as RRV (E2 K251R) allowed for escape from clearance and enhanced viremia and dissemination. Mutational analysis revealed that viral clearance from the circulation is strictly dependent on the presence of lysine at these positions. These findings reveal a previously unrecognized innate immune pathway that controls alphavirus viremia and dissemination in vertebrate hosts, ultimately influencing disease severity and likely transmission efficiency.

Immunoglobulin G, complement factor C3 and lymphocytes in proliferative intraocular disorders

1990 ◽  
Vol 14 (4) ◽  
pp. 277-283 ◽  
Author(s):  
Michael Weller ◽  
Ralf Clausen ◽  
Martin Bresgen ◽  
Klaus Heimann ◽  
Peter Wiedemann
Keyword(s):  
Immunoglobulin G ◽  
Complement Factor ◽  
Complement Factor C3

Some histochemical characteristics of the mucous microenvironment in four salmonids with different susceptibilities to gyrodactylid infections

1998 ◽  
Vol 72 (2) ◽  
pp. 101-107 ◽  
Author(s):  
K. Buchmann
Keyword(s):  
Rainbow Trout ◽  
Brown Trout ◽  
Lectin Binding ◽  
Mucous Cell ◽  
Complement Factor ◽  
Binding Assays ◽  
Susceptibility To Infection ◽  
Resistance To Infection ◽  
Cell Densities ◽  
Complement Factor C3

AbstractSkin mucous cells and mucus from four salmonids (rainbow trout, brown trout, Conon salmon, Iijoki salmon) with different susceptibilities to infection withGyrodactylus derjaviniandG. salariswere partly characterized by cytochemistry, immunoblotting and immunocytochemistry. Mucous cell densities in various fin types were partly correlated with resistance to infection withG. derjavinibut not withG. salaris. Lectin binding assays indicated slight differences in carbohydrate composition of mucus from the four salmonids but serum antigens specific for salmonids were found in mucus from all of them. Antisera against salmon immunoglobulin and rainbow trout complement factor C3 reacted with mucus from all of the salmonids but not with mucus from phylogenetically unrelated fish. Antisera raised against ACTH reacted with mucus components from rainbow trout, brown trout and Conon salmon but not with mucus from Iijoki salmon. These findings are discussed in relation to the host specificity of ectoparasites and susceptibility to infection.

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