scholarly journals High Frequency of 16S Ribosomal RNA Methyltransferases among Klebsiella pneumoniae Isolates: First Report of rmtA, rmtD, rmtE and rmtF Resistance Genes in Iran

2020 ◽  
Vol 6 (3) ◽  
pp. 153-163
Author(s):  
Fatemeh Ahmadian Alashti ◽  
◽  
Maryam Ghane ◽  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Ribosomal Rna ◽  
Resistance Genes ◽  
High Frequency ◽  
16S Ribosomal Rna ◽  
First Report

scholarly journals Klebsiella pneumoniae as a key trafficker of drug resistance genes from environmental to clinically important bacteria

2018 ◽  
Author(s):  
Kelly L Wyres ◽  
Kathryn E Holt
Keyword(s):  
Klebsiella Pneumoniae ◽  
Resistance Genes ◽  
High Frequency ◽  
Gene Diversity ◽  
Bacterial Pathogen ◽  
Carbapenem Resistance ◽  
Clinical Problem ◽  
Current Evidence ◽  
Ecological Distribution ◽  
Environmental Microbes

Klebsiella pneumoniae is an opportunistic bacterial pathogen known for its high frequency and diversity of antimicrobial resistance (AMR) genes. In addition to being a significant clinical problem in its own right, K. pneumoniae is the species within which several new AMR genes were first discovered before spreading to other pathogens (e.g. carbapenem-resistance genes KPC, OXA-48 and NDM-1). Whilst K. pneumoniae’s contribution to the overall AMR crisis is impossible to quantify, current evidence suggests it has a wider ecological distribution, significantly more varied DNA composition, greater AMR gene diversity and a higher plasmid burden than other Gram negative opportunists. Hence we propose it plays a key role in disseminating AMR genes from environmental microbes to clinically important pathogens.

scholarly journals Prevalence of Plasmid-Mediated Quinolone Resistance Genes among Extended-Spectrumβ-Lactamase-ProducingKlebsiella pneumoniaeHuman Isolates in Iran

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Ehsaneh Shams ◽  
Farzaneh Firoozeh ◽  
Rezvan Moniri ◽  
Mohammad Zibaei
Keyword(s):  
Klebsiella Pneumoniae ◽  
Resistance Genes ◽  
High Frequency ◽  
Quinolone Resistance ◽  
Confirmatory Test ◽  
Diffusion Method ◽  
Disk Diffusion Method ◽  
Pcr Products ◽  
Pcr Method

The purpose of this study was to determine the prevalence and molecular characterization of plasmid-mediated quinolone resistance (PMQR) genes (qnrA, qnrB, qnrS, aac(6′)-Ib-cr, andqepA) among ESBL-producingKlebsiella pneumoniaeisolates in Kashan, Iran. A total of 185K. pneumoniaeisolates were tested for quinolone resistance and ESBL-producing using the disk diffusion method and double disk synergy (DDST) confirmatory test. ESBL-producing strains were further evaluated for theblaCTX-Mgenes. The PCR method was used to show presence of plasmid-mediated quinolone resistance genes and the purified PCR products were sequenced. Eighty-seven ESBL-producing strains were identified by DDST confirmatory test and majority (70, 80.5%) of which carriedblaCTX-Mgenes including CTX-M-1 (60%), CTX-M-2 (42.9%), and CTX-M-9 (34.3%). Seventy-seven ESBL-producingK. pneumoniaeisolates harbored PMQR genes, which mostly consisted ofaac(6′)-Ib-cr(70.1%) andqnrB(46.0%), followed byqnrS(5.7%). Among the 77 PMQR-positive isolates, 27 (35.1%) and 1 (1.3%) carried 2 and 3 different PMQR genes, respectively. However,qnrAandqepAwere not found in any isolate. Our results highlight high ESBL occurrence with CTX-M type and high frequency of plasmid-mediated quinolone resistance genes among ESBL-producingK. pneumoniaeisolates in Kashan.

scholarly journals 16S ribosomal RNA methylase RmtD produced by Klebsiella pneumoniae in Brazil

2008 ◽  
Vol 61 (3) ◽  
pp. 746-747 ◽  
Author(s):  
K. Yamane ◽  
F. Rossi ◽  
M. G. M. A. Barberino ◽  
J. M. Adams-Haduch ◽  
Y. Doi ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Ribosomal Rna ◽  
16S Ribosomal Rna

High-Frequency Involved Hearing Loss Caused by Novel Mitochondrial DNA Mutation in 16S Ribosomal RNA Gene

2014 ◽  
Vol 35 (6) ◽  
pp. 1087-1090
Author(s):  
Satoko Abe ◽  
Makoto Nagano ◽  
Shin-ya Nishio ◽  
Kozo Kumakawa ◽  
Shin-ichi Usami
Keyword(s):  
Hearing Loss ◽  
Mitochondrial Dna ◽  
Ribosomal Rna ◽  
High Frequency ◽  
16S Ribosomal Rna ◽  
Mitochondrial Dna Mutation ◽  
Ribosomal Rna Gene ◽  
Dna Mutation ◽  
16S Ribosomal Rna Gene

scholarly journals Klebsiella pneumoniae as a key trafficker of drug resistance genes from environmental to clinically important bacteria

2018 ◽  
Author(s):  
Kelly L Wyres ◽  
Kathryn E Holt
Keyword(s):  
Klebsiella Pneumoniae ◽  
Resistance Genes ◽  
High Frequency ◽  
Gene Diversity ◽  
Bacterial Pathogen ◽  
Carbapenem Resistance ◽  
Clinical Problem ◽  
Current Evidence ◽  
Ecological Distribution ◽  
Environmental Microbes

Klebsiella pneumoniae is an opportunistic bacterial pathogen known for its high frequency and diversity of antimicrobial resistance (AMR) genes. In addition to being a significant clinical problem in its own right, K. pneumoniae is the species within which several new AMR genes were first discovered before spreading to other pathogens (e.g. carbapenem-resistance genes KPC, OXA-48 and NDM-1). Whilst K. pneumoniae’s contribution to the overall AMR crisis is impossible to quantify, current evidence suggests it has a wider ecological distribution, significantly more varied DNA composition, greater AMR gene diversity and a higher plasmid burden than other Gram negative opportunists. Hence we propose it plays a key role in disseminating AMR genes from environmental microbes to clinically important pathogens.

scholarly journals Ultra high frequency ultrasonography to distinguish ganglionic from aganglionic bowel wall in Hirschsprung disease: A first report

2021 ◽  
Author(s):  
Christina Granéli ◽  
Tobias Erlöv ◽  
Rodrigo Munoz Mitev ◽  
Ioanna Kasselaki ◽  
Kristine Hagelsteen ◽  
...  
Keyword(s):  
High Frequency ◽  
Bowel Wall ◽  
Hirschsprung Disease ◽  
First Report ◽  
Ultra High Frequency ◽  
High Frequency Ultrasonography

Emergence and Recovery of Ceftazidime-avibactam Resistance in blaKPC-33-Harboring Klebsiella pneumoniae Sequence Type 11 Isolates in China

2020 ◽  
Vol 71 (Supplement_4) ◽  
pp. S436-S439
Author(s):  
Qingyu Shi ◽  
Dandan Yin ◽  
Renru Han ◽  
Yan Guo ◽  
Yonggui Zheng ◽  
...  
Keyword(s):  
Klebsiella Pneumoniae ◽  
Infection Control ◽  
Polymyxin B ◽  
Sequence Type ◽  
First Report ◽  
Clinical Strains

Abstract This is the first report of ceftazidime–avibactam resistance caused by the blaKPC-33 mutation through the D179Y variant during the treatment of blaKPC-2-positive Klebsiella pneumoniae-related infections in China. The blaKPC-33-containing K. pneumoniae was susceptible to meropenem–vaborbactam, cefepime–zidebactam, tigecycline, and polymyxin B. The blaKPC-33 gene was located on a 77 551-bp transformable plasmid harboring qnrS1 and blaLAP-2. Detecting blaKPC-33-positive K. pneumoniae clinical strains is important for infection control.

scholarly journals A functional pseudoknot in 16S ribosomal RNA.

1991 ◽  
Vol 10 (8) ◽  
pp. 2203-2214 ◽  
Author(s):  
T. Powers ◽  
H.F. Noller
Keyword(s):  
Ribosomal Rna ◽  
16S Ribosomal Rna
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