scholarly journals The effect of hydroalcoholic extract of Zingiber officinale rhizomes on mechanical activity of isolated trachea of male rats

2014 ◽  
Vol 12 (1) ◽  
pp. 1-7 ◽  
Author(s):  
fereshteh dadfar ◽  
Aminolah Bahaeoidini ◽  
◽  
Keyword(s):  
Zingiber Officinale ◽  
Male Rats ◽  
Mechanical Activity ◽  
Hydroalcoholic Extract ◽  
Isolated Trachea

scholarly journals Effect of Zingiber Officinale on paracetamol-induced genotoxicity in male rats

2012 ◽  
Vol 6 (41) ◽  
pp. 5425-5434 ◽  
Author(s):  
S H Salah ◽  
S Abdouh ◽  
Booles Hodaf ◽  
Rahim E A Abdel
Keyword(s):  
Zingiber Officinale ◽  
Male Rats

scholarly journals The Effect of Hydroalcoholic Extract of Perovskia Abrotanoides on Neuronal Density of Rats under Chronic Immobility Stress

2020 ◽  
Author(s):  
Maryam Tehranipour ◽  
Rahele Pakjame ◽  
Saiede Zafar Balanezhad
Keyword(s):  
Antioxidant Properties ◽  
Negative Control ◽  
Male Rats ◽  
Hydroalcoholic Extract ◽  
Stress Group ◽  
Neuronal Density ◽  
Ca1 Region ◽  
The Mean ◽  
The Brain ◽  
Experimental Group

Introduction: The number of neurons in the hippocampus can have a direct effect on its function. The plant Brazembel from the mint family may have antioxidant properties. The aim of the present study was to investigate the effects of stress and Brazmble extract on neuronal density of CA1, CA2 in male rats. Methods: In this experimental study, Wistar rats were divided into 6 groups (n=5), including control, and negative control under stress, also experimental group,including stress and get Brazmbl doses of the extract mL 50, mL 75 and mL 100. Limiting stress for 21 days, the rats were exposed in 2 hours. Groups receiving the extract for 21 days, to get inside limiting extracts were gavaged. After removal of the brain by perfusion, the hippocampus was excised and stained, and the neuronal density was calculated by dissector and metasteriology. The results were analyzed by Minitab 16 software with t-test and ANOVA at a significant level (P <0.05). Results: Statistical analysis of the data showed that the mean neuronal density in the stress group compared to the control in CA1 and CA2 had a significant decrease (p <0.01). The mean neuronal density of CA1 region between the stress group (29 ± 3) and hydroalcoholic treatment at 50 mg / kg (25 ± 3) showed a significant increase. In addition, the mean neuronal density in the stress group with 75 mg / kg extract (27±3) and in the group treated with hydroalcoholic extract was 100 mg / kg (25 ± 3). Mean neuronal density of CA2 region between the stress (21 ± 3) and hydroalcoholic treatment at 50 mg / kg (28 ± 3) groups showed a significant increase (p <0.01). The mean neuronal density in the stress group with 75 mg / kg extract was 27 ± 3 and in the hydroalcoholic extract treatment group was 100 mg / kg (22 ± 3), which increased significantly compared to the stress group (p <0.01). Conclusion: The results of the current study show that the hydroalcoholic extract of plant Bromzebel probably increases the neuronal density of the brain hippocampus due to its polyphenolic substances such as flavonoids, which is due to its high antioxidant properties.

scholarly journals Evaluation of Antidiabetic and Antihyperlipidemic Effects of Peganum harmala Seeds in Diabetic Rats

Cholesterol ◽  
2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Gholamreza Komeili ◽  
Mohammad Hashemi ◽  
Mohsen Bameri-Niafar
Keyword(s):  
Total Cholesterol ◽  
Glycosylated Hemoglobin ◽  
Diabetic Rats ◽  
Male Rats ◽  
Peganum Harmala ◽  
Hydroalcoholic Extract ◽  
End Of Treatment ◽  
Total Antioxidant ◽  
Treatment Of Diabetes ◽  
Different Doses

The present study was carried out to investigate the antidiabetic and antihyperlipidemic properties of hydroalcoholic extract of Peganum harmala in streptozotocin-induced diabetic male rats. In an experimental study, 64 normal Wistar albino male rats (200–230 g) were randomly divided into 8 groups. Control and diabetic rats were treated with normal saline and three different doses (30, 60, and 120 mg/kg) of hydroalcoholic extract of Peganum harmala seeds for 4 weeks orally. At the end of treatment, blood samples were taken and glucose, triglycerides, total cholesterol, LDL-c, HDL-c, malondialdehyde (MDA), total antioxidant capacity (TCA), ALT, AST, GGT, bilirubin, and glycosylated hemoglobin (HbA1C) were determined. STZ-induced diabetic rats showed significant changes in the values of glucose, triglycerides, total cholesterol, LDL-c, MDA, TAC, ALT, AST, GGT, bilirubin, and HbA1C in comparison with normal rats. Administration of the extract to diabetic rats resulted in a remarkable decrease in glucose, lipid profiles, MDA, ALT, AST, GGT, bilirubin, and HbA1C levels and increase in TAC relative to diabetic group. The results of this study indicated that hydroalcoholic extract of Peganum harmala seeds possesses antidiabetic and hypolipidemic activities and could be useful in treatment of diabetes.

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