scholarly journals THE EXPERIMENTAL TRIALS OF 2% LIDOCAINE HYDROCHLORIDE SOLUTION HEPATOTOXICITY FOR DIFFERENT NUMBER OF INJECTIONS

2018 ◽  
Vol 1 (2) ◽  
pp. 318
Author(s):  
I. O. Pohodenko-Chudakova ◽  
E. V. Maksimovich
Keyword(s):  
Lidocaine Hydrochloride ◽  
Experimental Trials ◽  
Hydrochloride Solution ◽  
Number Of Injections

Evaluation of Middle and Distal Esophageal Diverticuli with Transnasal Esophagoscopy

2005 ◽  
Vol 114 (4) ◽  
pp. 276-278 ◽  
Author(s):  
Veena V. Kumar ◽  
Milan R. Amin
Keyword(s):  
Informed Consent ◽  
Case Reports ◽  
Lidocaine Hydrochloride ◽  
Review Of The Literature ◽  
Efficient Tool ◽  
Office Setting ◽  
Endoscopic Findings ◽  
Globus Sensation ◽  
Transnasal Esophagoscopy ◽  
Hydrochloride Solution

To emphasize the utility of office-based transnasal esophagoscopy (TNE) in the evaluation of patients with swallowing complaints, we present 2 case reports and a review of the literature. The 2 patients both presented with complaints of chronic dysphagia, globus sensation, and a sensation of “food sticking” with swallowing. The patients were counseled to undergo esophagoscopy. Informed consent was obtained. The nasal cavities and pharynx were anesthetized with topical 4% lidocaine hydrochloride solution. Transnasal esophagoscopy was performed. The procedure was well tolerated by the patients. Esophagoscopy revealed diverticuli in various segments of the esophagus, including the midesophageal and distal areas. The cause of the patients' complaints could be well attributed to the endoscopic findings. No morbidity was associated with the TNE examination. A review of the literature concerning office-based TNE was performed. We found no published reports of middle or distal esophageal diverticuli detected on routine office TNE. We conclude that transnasal esophagoscopy is a relatively safe and efficient tool that can be used in the office setting for evaluation of swallowing complaints.

scholarly journals Oral Mucosal Injection of a Local Anesthetic Solution Containing Epinephrine Enhances Muscle Relaxant Effects of Rocuronium

2012 ◽  
Vol 59 (1) ◽  
pp. 18-21 ◽  
Author(s):  
Asako Ninomiya ◽  
Yui Terakawa ◽  
Nobuyuki Matsuura ◽  
Tatsuya Ichinohe ◽  
Yuzuru Kaneko
Keyword(s):  
Muscle Relaxant ◽  
Infusion Rate ◽  
Nasotracheal Intubation ◽  
Lidocaine Hydrochloride ◽  
Rocuronium Bromide ◽  
Start Of Injection ◽  
Train Of Four ◽  
Relevant Dose ◽  
Epinephrine Dose ◽  
Hydrochloride Solution

The purpose of this study was to examine how submucosal injection of a clinically relevant dose of a lidocaine hydrochloride solution containing epinephrine affects the muscle relaxant effects of rocuronium bromide. Sixteen patients scheduled for orthognathic surgery participated in this study. All patients were induced with fentanyl citrate, a target-controlled infusion of propofol and rocuronium bromide. Anesthesia was maintained by total intravenous anesthesia. After nasotracheal intubation, an infusion of rocuronium bromide was started at 7 µg/kg/min, and the infusion rate was then adjusted to maintain a train of four (TOF) ratio at 10 to 15%. The TOF ratio just prior to oral mucosal injection of a 1% lidocaine hydrochloride solution containing 10 µg/mL epinephrine (LE) was taken as the baseline. TOF ratio was observed for 20 minutes, with 1-minute intervals following the start of injection. Mean epinephrine dose was 85.6 ± 18.6 µg and mean infusion rate of rocuronium bromide was 6.3 ± 1.6 µg/kg/min. TOF ratio began to decrease 2 minutes after the injection of LE, reached the minimum value at 3.1 ± 3.6% 12 minutes after the injection, and then began to recover. We conclude that oral mucosal injection of LE enhances the muscle relaxant effects of rocuronium bromide.

scholarly journals Buffered Lidocaine Hydrochloride Solution With and Without Epinephrine: Stability in Polypropylene Syringes

2009 ◽  
Vol 62 (5) ◽  
Author(s):  
Ronald F Donnelly ◽  
Elena Pascuet ◽  
Danielle Garceau ◽  
Régis Vaillancourt
Keyword(s):  
Lidocaine Hydrochloride ◽  
Hydrochloride Solution

scholarly journals Diffusion of lidocaine hydrochloride from lipid microparticles

2009 ◽  
Vol 15 (1) ◽  
pp. 33-35 ◽  
Author(s):  
Rada Pjanovic ◽  
Radoslava Stojanovic ◽  
Milana Sajber ◽  
Jelena Veljkovic ◽  
Nevenka Boskovic-Vragolovic ◽  
...  
Keyword(s):  
Drug Release ◽  
Diffusion Rate ◽  
Drug Carriers ◽  
Lidocaine Hydrochloride ◽  
Diffusion Cell ◽  
Sustained Drug Release ◽  
Franz Diffusion Cell ◽  
Diffusion Rates ◽  
Hydrochloride Solution ◽  
Prolonged Drug Release

Lipid particles, as drug carriers, are of increasing research interest, because a sustained drug release and avoidance of side effects could be achieved by using them. Lidocaine hydrochloride is a very efficient local anesthetic, but it has a short effect. The objective was to prolong the effect of the drug by encapsulating lidocaine hydrochloride in phospholipids microparticles. Two different procedures were used for the preparation of phospholipids microparticles. In both cases, phosphatidylcholine and lysophosphatidylcholine were used for the preparation of microparticles in which 5 % w/w lidocaine hydrochloride solution was encapsulated. The standard Franz diffusion cell was used for the experimental diffusion rate determination. The obtained results show that diffusion rate from microparticles is significantly lower than from the lidocaine hydrochloride solution, which means that this kind of microparticles could be used for the prolonged drug release. There was no much difference in diffusion rates from microparticles obtained by different procedures. That indicates that only the composition of the particles membrane has an influence on the lidocaine hydrochloride release rate.

The CSF p-tau181/Aβ42 Ratio Offers a Good Accuracy “In Vivo” in the Differential Diagnosis of Alzheimer’s Dementia

2019 ◽  
Vol 16 (7) ◽  
pp. 587-595 ◽  
Author(s):  
Roberto Santangelo ◽  
Alessandro Dell'Edera ◽  
Arianna Sala ◽  
Giordano Cecchetti ◽  
Federico Masserini ◽  
...  
Keyword(s):  
Clinical Practice ◽  
Clinical Diagnosis ◽  
Fdg Pet ◽  
Amyloid Β ◽  
Cost Effective ◽  
Daily Clinical Practice ◽  
Different Types ◽  
Experimental Trials ◽  
Csf Findings

Background: The incoming disease-modifying therapies against Alzheimer’s disease (AD) require reliable diagnostic markers to correctly enroll patients all over the world. CSF AD biomarkers, namely amyloid-β 42 (Aβ42), total tau (t-tau), and tau phosphorylated at threonine 181 (p-tau181), showed good diagnostic accuracy in detecting AD pathology, but their real usefulness in daily clinical practice is still a matter of debate. Therefore, further validation in complex clinical settings, that is patients with different types of dementia, is needed to uphold their future worldwide adoption. Methods: We measured CSF AD biomarkers’ concentrations in a sample of 526 patients with a clinical diagnosis of dementia (277 with AD and 249 with Other Type of Dementia, OTD). Brain FDG-PET was also considered in a subsample of 54 patients with a mismatch between the clinical diagnosis and the CSF findings. Results: A p-tau181/Aβ42 ratio higher than 0.13 showed the best diagnostic performance in differentiating AD from OTD (86% accuracy index, 74% sensitivity, 81% specificity). In cases with a mismatch between clinical diagnosis and CSF findings, brain FDG-PET partially agreed with the p-tau181/Aβ42 ratio, thus determining an increase in CSF accuracy. Conclusions: The p-tau181/Aβ42 ratio alone might reliably detect AD pathology in heterogeneous samples of patients suffering from different types of dementia. It might constitute a simple, cost-effective and reproducible in vivo proxy of AD suitable to be adopted worldwide not only in daily clinical practice but also in future experimental trials, to avoid the enrolment of misdiagnosed AD patients.

scholarly journals An Optimal Footprint Based Coverage Planning for Hydro Blasting Robots

Sensors ◽  
2021 ◽  
Vol 21 (4) ◽  
pp. 1194
Author(s):  
Thejus Pathmakumar ◽  
Madan Mohan Rayguru ◽  
Sriharsha Ghanta ◽  
Manivannan Kalimuthu ◽  
Mohan Rajesh Elara
Keyword(s):  
Genetic Algorithm ◽  
Mobile Robots ◽  
Numerical Simulations ◽  
Labour Force ◽  
Successful Implementation ◽  
Multi Objective Optimization ◽  
Metallic Surfaces ◽  
Industrial Sites ◽  
Experimental Trials ◽  
Time And Energy

The hydro blasting of metallic surfaces is an essential maintenance task in various industrial sites. Its requirement of a considerable labour force and time, calls for automating the hydro blasting jobs through mobile robots. A hydro blasting robot should be able to cover the required area for a successful implementation. If a conventional robot footprint is chosen, the blasting may become inefficient, even though the concerned area is completely covered. In this work, the blasting arm’s sweeping angle is chosen as the robot’s footprint for hydro blasting task, and a multi-objective optimization-based framework is proposed to compute the optimal sweeping arc. The genetic algorithm (GA) methodology is exploited to compute the optimal footprint, which minimizes the blasting time and energy simultaneously. Multiple numerical simulations are performed to show the effectiveness of the proposed approach. Moreover, the strategy is successfully implemented on our hydro blasting robot named Hornbill, and the efficacy of the proposed approach is validated through experimental trials.

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