scholarly journals Buffered Lidocaine Hydrochloride Solution With and Without Epinephrine: Stability in Polypropylene Syringes

2009 ◽  
Vol 62 (5) ◽  
Author(s):  
Ronald F Donnelly ◽  
Elena Pascuet ◽  
Danielle Garceau ◽  
Régis Vaillancourt
Keyword(s):  
Lidocaine Hydrochloride ◽  
Hydrochloride Solution

Evaluation of Middle and Distal Esophageal Diverticuli with Transnasal Esophagoscopy

2005 ◽  
Vol 114 (4) ◽  
pp. 276-278 ◽  
Author(s):  
Veena V. Kumar ◽  
Milan R. Amin
Keyword(s):  
Informed Consent ◽  
Case Reports ◽  
Lidocaine Hydrochloride ◽  
Review Of The Literature ◽  
Efficient Tool ◽  
Office Setting ◽  
Endoscopic Findings ◽  
Globus Sensation ◽  
Transnasal Esophagoscopy ◽  
Hydrochloride Solution

To emphasize the utility of office-based transnasal esophagoscopy (TNE) in the evaluation of patients with swallowing complaints, we present 2 case reports and a review of the literature. The 2 patients both presented with complaints of chronic dysphagia, globus sensation, and a sensation of “food sticking” with swallowing. The patients were counseled to undergo esophagoscopy. Informed consent was obtained. The nasal cavities and pharynx were anesthetized with topical 4% lidocaine hydrochloride solution. Transnasal esophagoscopy was performed. The procedure was well tolerated by the patients. Esophagoscopy revealed diverticuli in various segments of the esophagus, including the midesophageal and distal areas. The cause of the patients' complaints could be well attributed to the endoscopic findings. No morbidity was associated with the TNE examination. A review of the literature concerning office-based TNE was performed. We found no published reports of middle or distal esophageal diverticuli detected on routine office TNE. We conclude that transnasal esophagoscopy is a relatively safe and efficient tool that can be used in the office setting for evaluation of swallowing complaints.

scholarly journals Oral Mucosal Injection of a Local Anesthetic Solution Containing Epinephrine Enhances Muscle Relaxant Effects of Rocuronium

2012 ◽  
Vol 59 (1) ◽  
pp. 18-21 ◽  
Author(s):  
Asako Ninomiya ◽  
Yui Terakawa ◽  
Nobuyuki Matsuura ◽  
Tatsuya Ichinohe ◽  
Yuzuru Kaneko
Keyword(s):  
Muscle Relaxant ◽  
Infusion Rate ◽  
Nasotracheal Intubation ◽  
Lidocaine Hydrochloride ◽  
Rocuronium Bromide ◽  
Start Of Injection ◽  
Train Of Four ◽  
Relevant Dose ◽  
Epinephrine Dose ◽  
Hydrochloride Solution

The purpose of this study was to examine how submucosal injection of a clinically relevant dose of a lidocaine hydrochloride solution containing epinephrine affects the muscle relaxant effects of rocuronium bromide. Sixteen patients scheduled for orthognathic surgery participated in this study. All patients were induced with fentanyl citrate, a target-controlled infusion of propofol and rocuronium bromide. Anesthesia was maintained by total intravenous anesthesia. After nasotracheal intubation, an infusion of rocuronium bromide was started at 7 µg/kg/min, and the infusion rate was then adjusted to maintain a train of four (TOF) ratio at 10 to 15%. The TOF ratio just prior to oral mucosal injection of a 1% lidocaine hydrochloride solution containing 10 µg/mL epinephrine (LE) was taken as the baseline. TOF ratio was observed for 20 minutes, with 1-minute intervals following the start of injection. Mean epinephrine dose was 85.6 ± 18.6 µg and mean infusion rate of rocuronium bromide was 6.3 ± 1.6 µg/kg/min. TOF ratio began to decrease 2 minutes after the injection of LE, reached the minimum value at 3.1 ± 3.6% 12 minutes after the injection, and then began to recover. We conclude that oral mucosal injection of LE enhances the muscle relaxant effects of rocuronium bromide.

scholarly journals Diffusion of lidocaine hydrochloride from lipid microparticles

2009 ◽  
Vol 15 (1) ◽  
pp. 33-35 ◽  
Author(s):  
Rada Pjanovic ◽  
Radoslava Stojanovic ◽  
Milana Sajber ◽  
Jelena Veljkovic ◽  
Nevenka Boskovic-Vragolovic ◽  
...  
Keyword(s):  
Drug Release ◽  
Diffusion Rate ◽  
Drug Carriers ◽  
Lidocaine Hydrochloride ◽  
Diffusion Cell ◽  
Sustained Drug Release ◽  
Franz Diffusion Cell ◽  
Diffusion Rates ◽  
Hydrochloride Solution ◽  
Prolonged Drug Release

Lipid particles, as drug carriers, are of increasing research interest, because a sustained drug release and avoidance of side effects could be achieved by using them. Lidocaine hydrochloride is a very efficient local anesthetic, but it has a short effect. The objective was to prolong the effect of the drug by encapsulating lidocaine hydrochloride in phospholipids microparticles. Two different procedures were used for the preparation of phospholipids microparticles. In both cases, phosphatidylcholine and lysophosphatidylcholine were used for the preparation of microparticles in which 5 % w/w lidocaine hydrochloride solution was encapsulated. The standard Franz diffusion cell was used for the experimental diffusion rate determination. The obtained results show that diffusion rate from microparticles is significantly lower than from the lidocaine hydrochloride solution, which means that this kind of microparticles could be used for the prolonged drug release. There was no much difference in diffusion rates from microparticles obtained by different procedures. That indicates that only the composition of the particles membrane has an influence on the lidocaine hydrochloride release rate.

scholarly journals Placental transfer of lidocaine hydrochloride after prolonged continuous maternal intravenous administration

1995 ◽  
Vol 42 (4) ◽  
pp. 338-340 ◽  
Author(s):  
Michio Banzai ◽  
Satoshi Sato ◽  
Naohiro Tezuka ◽  
Hiromi Komiya ◽  
Tetsuro Chimura ◽  
...  
Keyword(s):  
Intravenous Administration ◽  
Placental Transfer ◽  
Lidocaine Hydrochloride

Epidural Blockade for Cesarean Section Comparing Lidocaine Hydrocarbonate and Lidocaine Hydrochloride

1985 ◽  
Vol 62 (3) ◽  
pp. 348-350 ◽  
Author(s):  
Colm P. Cole ◽  
Graham H. McMorland ◽  
James E. Axelson ◽  
Leonard C. Jenkins
Keyword(s):  
Cesarean Section ◽  
Lidocaine Hydrochloride ◽  
Epidural Blockade ◽  
Lidocaine Hydrocarbonate

Factors Affecting Gelation of Lidocaine Hydrochloride-Loaded Polyelectrolyte Complex Thermosensitivity Gel for Dry Socket Treatment

2021 ◽  
Vol 901 ◽  
pp. 111-116
Author(s):  
Nuttawut Supachawaroj ◽  
Sucharat Limsitthichaikoon
Keyword(s):  
Polyelectrolyte Complex ◽  
Gelation Time ◽  
Lidocaine Hydrochloride ◽  
Gelation Temperature ◽  
High Concentration ◽  
Preparation Methods ◽  
Factors Affecting ◽  
Dry Socket ◽  
Short Period ◽  
Gel Preparation

Dry socket disease, a pocket wound caused by the tooth extraction that resulted in severe acute pain which requires a topical analgesic with rapidly pain reduction and suppress the pain until the wound healed. This study aimed to investigate factors affecting gelation temperature and gelation time of lidocaine hydrochloride (LH)-loaded polyelectrolyte complex (PEC) thermosensitivity gel for treating dry socket wound. The first factor was investigated the effects of the ratio of three different types of polymers as chitosan (CS), hyaluronic acid (HA) and poloxamer407 (P407) on the phase transition caused by temperature. The second factor was examined the effects of gel preparation methods. The results showed that increasing concentration of the cationic polymer as CS induced the separation of the solution to gel (sol-to-gel) system due to the charge of CS and the charge of PEC. The ratio of HA:P407 affected the gel forming which high concentration of P407 reduced the gelation temperature while low concentration of HA disturbed the sol-to-gel state causing coagulation. The viscosity, spreadability, and swelling were significantly increased due to the concomitant increased in each polymer, HA and P407. The particle of the formulation observed under microscope was found to be less than 1 µm. Phase inversion from sol-to-gel was found after a min at 23°C. Since gelation temperature of the purposed formula is supposed to form gel below 37°C within a short period of injection. The results of the study indicate the suitable sol-to-gel forming in the appropriate temperature and time which should be used for further investigation in the efficacy and safety.

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