scholarly journals Korelasi antara Jumlah Limfosit Total dan Limfosit Cd4+ pada Pasien HIV/AIDS di RSUD Provinsi NTB

2019 ◽  
Vol 8 (2) ◽  
pp. 24
Author(s):  
I Made Wikrama Resindra ◽  
Ilsa Hunaifi ◽  
I Gede Yasa Asmara
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiretroviral Therapy ◽  
Ribonucleic Acid ◽  
Highly Active Antiretroviral Therapy ◽  
Deoxyribonucleic Acid ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
Highly Active ◽  
Immunodeficiency Virus ◽  
Hiv Aids

Latar belakang: HIV (Human Immunodeficiency Virus) merupakan suatu jenis retrovirus yang berasal dari famili lentivirus. Virus ini memiliki kemampuan khusus yaitu merubah komponen RNA (Ribonucleic Acid) menjadi DNA (Deoxyribonucleic Acid). Virus HIV merupakan jenis virus yang menyerang sel limfosit CD (Cluster Differentiation) 4+ . Negara Indonesia merupakan negara kepulauan yang masih memiliki keterbatasan dalam melakukan pemeriksaan CD4+. Hitung jumlah limfosit total dapat dijadikan alternatif menggantikan pemeriksaan CD4+ dalam menentukan waktu terapi HAART (Highly Active Antiretroviral Therapy) atau melakukan monitoring. Secara umum tujuan penelitian ini adalah untuk mengetahui korelasi antara jumlah limfosit total dan limfosit CD4+ pada pasien HIV/AIDS di RSUD Provinsi NTB. Metode: Penelitian ini menggunakan metode kuantitatif dengan metode pengambilan data secara cross-sectional. Sampel penelitian yang telah memenuhi kriteria inklusi dan eksklusi dipilih berdasarkan teknik consecutive sampling. Pengambilan data menggunakan data rekam medis pasien HIV/AIDS pada klinik VCT (Voluntary Conseling and Testing). Analisis statistik yang digunakan yaitu analisis deskriptif dan bivariat dengan uji korelasi pearson. Hasil: Sebanyak 52 sampel yang masuk kedalam kriteria inklusi didapatkan nilai korelasi positif lemah antara jumlah limfosit total dan CD4+ pada sampel pre-HAART (r = 0.396) dengan nilai sig 0.004 sedangkan pada sampel post-HAART didapatkan korelasi positif kuat (r = 0.665) dengan nilai sig 0.000. Kesimpulan: Terdapat korelasi yang signifikan antara TLC dan CD4+ pre-HAART dan post-HAART

scholarly journals The effect of highly active antiretroviral therapy on the prevalence of oral manifestation in human immunodeficiency virus-infected patients in Karnataka, India

2015 ◽  
Vol 09 (01) ◽  
pp. 047-052 ◽  
Author(s):  
Neelkant Patil ◽  
Vishwajit Rampratap Chaurasia ◽  
Prashant Babaji ◽  
Dnsv Ramesh ◽  
Kshitij Jhamb ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Oral Manifestations ◽  
Cross Sectional ◽  
Clinical Criteria ◽  
Oral Manifestation ◽  
Highly Active ◽  
Group I ◽  
Immunodeficiency Virus

ABSTRACT Objectives: Acquired Immunodeficiency Syndrome (AIDS) is a highly lethal, progressively epidemic viral infection characterized by profound impairment of the immune system. Oral manifestations are common in Human Immunodeficiency Virus (HIV) infected AIDS patients, and are usually the first indicator of symptom and disease progression. The main objective of the current study was to compare the prevalence of oral manifestations in HIV patients on Highly Active Antiretroviral Therapy (HAART) with those, not on HAART therapies. Materials and Methods: A cross sectional study was conducted among 100 patients diagnosed as human immune virus sero-positive. These patients were divided equally into two groups (50 each); Group I patients on HAART and Group II patients who were not on HAART. Information regarding age, sex and cluster of differentiation 4 cell count was obtained from the medical records. Oral examination was done, and findings were recorded by using internationally accepted presumptive clinical criteria. Statistical analysis was performed using Chi-square statistical test. Results: The presence of oral manifestations was significantly decreased in subjects on HAART (32%) compared to those who are not on HAART (56%). The most common oral lesions detected in patients on HAART were increased oral hyper-pigmentation (14%), recurrent aphthous stomatitis (8%), non-specific ulcerations (4%), pseudo-membranous candidiasis (2%), periodontitis (2%) and xerostomia (2%), whereas in non HAART oral hyperpigmentation (10%), pseudo-membranous candidiasis (8%), angular cheilitis (4%), and erythematous candidiasis (4%) and Periodontitis (14%) were more prevalent. Conclusion: The number and severity of oral manifestation decreased, and even there was a change in the type of oral manifestations on HAART, which may be because of the improvement in immunity gained by the therapy.

scholarly journals Kardiomiopati pada Penderita Infeksi HIV

2017 ◽  
Vol 1 (2) ◽  
pp. 132
Author(s):  
Arif Sejati ◽  
Ika Prasetya Wijaya
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Highly Active ◽  
Immunodeficiency Virus ◽  
Hiv Aids

Jantung adalah salah satu organ yang dapat menjadi sumber morbiditas dan mortalitas pada penderita Human Immunodeficiency Virus (HIV)/ Acquired Immunodeificiency Syndrome (AIDS) namun jarang mendapat perhatian khusus. Sebelum era penggunaan highly active antiretroviral therapy (HAART) kelainan jantung khususnya kardiomiopati cukup sering ditemukan. Kardiomiopati didefinisikan sebagai kelompok penyakit heterogen yang dihubungkan dengan disfungsi mekanik dan/atau elektrik yang biasanya (namun tidak selalu) didapatkan hipertrofi atau dilatasi ventrikel yang abnormal dan disebabkan oleh beragam penyebab, kebanyakan genetik. Kardiomiopati pada pasien dengan HIV dapat digolongkan ke dalam kardiomiopati dilatasi yang didapat. Kardiomiopati pada penderita HIV/AIDS disebabkan oleh berbagai faktor: virus HIV, miokarditis, obat-obatan, dan status nutrisi. Pencegahan dan pengobatan dini HIV/AIDS menjadi faktor penting dalam mengurangi morbiditas dan mortalitas akibat kardiomiopati.

scholarly journals Highly Active Antiretroviral Therapy Normalizes the Function of Progenitor Cells in Human Immunodeficiency Virus–Infected Patients

1998 ◽  
Vol 178 (5) ◽  
pp. 1299-1305 ◽  
Author(s):  
Susanne Dam Nielsen ◽  
Annette Kjær Ersbøll ◽  
Lars Mathiesen ◽  
Jens Ole Nielsen ◽  
John‐Erik Stig Hansen
Keyword(s):  
Human Immunodeficiency Virus ◽  
Antiretroviral Therapy ◽  
Progenitor Cells ◽  
Highly Active Antiretroviral Therapy ◽  
Highly Active ◽  
Immunodeficiency Virus

scholarly journals Highly Active Antiretroviral Therapy in Human Immunodeficiency Virus Type 1-Infected Children: Analysis of Cellular Immune Responses

2001 ◽  
Vol 8 (5) ◽  
pp. 943-948 ◽  
Author(s):  
Vesna Blazevic ◽  
Shirley Jankelevich ◽  
Seth M. Steinberg ◽  
Freda Jacobsen ◽  
Robert Yarchoan ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
T Cell ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Delayed Type Hypersensitivity ◽  
Strong Increase ◽  
Highly Active ◽  
Cell Counts ◽  
Immunodeficiency Virus

ABSTRACT The present study analyzes the effect of highly active antiretroviral therapy (HAART) on restoration of cellular immunity in human immunodeficiency virus (HIV)-infected children over a 24-week period following initiation of HAART with ritonavir, nevirapine, and stavudine. The immunological parameters evaluated at four time points (at enrollment and at 4, 12, and 24 weeks of therapy) included cytokine production by monocytes as well as T-cell proliferation in response to mitogen, alloantigen, and recall antigens including HIV type 1 envelope peptides. Circulating levels of interleukin-16 (IL-16) were measured, in addition to CD4+ T-cell counts, plasma HIV RNA levels, and the delayed-type hypersensitivity (DTH) response. At enrollment the children exhibited defects in several immune parameters measured. Therapy increased CD4+ T-cell counts and decreased viral loads significantly. By contrast, the only immunological parameter that was significantly increased was IL-12 p70 production by monocytes; the DTH response to Candida albicans also showed a strong increase in patients becoming positive. In conclusion, these results demonstrate that HAART in HIV-infected children affects the dynamics of HIV replication and the CD4+ T-cell count over 24 weeks, similar to the pattern seen in HIV-infected adults. Furthermore, these data indicate improvement in antigen-presenting cell immunological function in HIV-infected children induced by HAART.

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