EFFECT OF PROPRANOLOL;

Tuberculosis is the disease required long term treatment. Rifampicin is the majorelement of antiTB therapy if resistance is not documented. Potential of antitubercular dugsto produced hepatoxicity is very high and among all antiTB agents rifampicin (RIF) inducedhepatoxicity stands on top. Rifampicin is the major element of antiTB therapy if resistance is notdocumented. But its hepatotoxic effects are the main hurdle to continue with this therapy. In thisstudy RIF were administered to the rabbit alone or in combination of propranolol to evaluate thehepatotoxic effects of RIF and reduction of hepatotoxicity by propranolol. Histological evaluationof liver tissue on higher magnification, its micrometric analysis and SEM (scanning electronmicroscopy) of liver were used to estimate the effects of this combination. Micrometry revealedthat number of viable hepatocytes, their diameter and nuclear diameter were altered. SEMmicrograph showed distorted and swollen hepatic cords. All of these changes successfullyturned to normal by combined administration of propranolol. Propranolol successfully improvesthe hepatic architecture proved by both qualitative and quantitative microscopy.

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Neuroendocrine Tests during Treatment with Neuroleptic Drugs. I. Plasma Prolactin Response to Haloperidol Challenge

The British Journal of Psychiatry ◽

10.1192/bjp.139.5.400 ◽

1981 ◽

Vol 139 (5) ◽

pp. 400-404 ◽

Cited By ~ 19

Author(s):

Tamara Kolakowska ◽

Louise Braddock ◽

David Wiles ◽

Michael Franklin ◽

Michael Gelder

Keyword(s):

Current Treatment ◽

Term Treatment ◽

Therapeutic Effects ◽

Plasma Prolactin ◽

Neuroleptic Drugs ◽

Long Term Treatment ◽

Prolactin Response ◽

Very High ◽

Substantial Rise

SummaryThe plasma prolactin (PRL) response to haloperidol 2 or 4 mg i.m. was studied in 18 schizophrenic men during their routine treatment with neuroleptic drugs. A substantial rise of the PRL level above the treatment baseline occurred in all but four of the 20 tests showing that the PRL elevation induced by treatment was not maximal. The challenge was ineffective only in patients receiving very high daily doses of medication. The increment was inversely correlated to the daily dose of medication but unrelated to plasma haloperidol concentrations during the test. Chronic schizophrenics who were receiving long term treatment and had low basal PRL levels did not show tolerance to the prolactin stimulating effect of haloperidol. That prolactin rose during the test in patients who had improved during their current treatment indicates that the degree of dopamine receptor blockade required for therapeutic effects is below that which produces a maximal PRL response.

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Report Form for Aggressive Episodes: Preliminary Report

Perceptual and Motor Skills ◽

10.2466/pms.1996.83.3f.1139 ◽

1996 ◽

Vol 83 (3_suppl) ◽

pp. 1139-1152 ◽

Cited By ~ 15

Author(s):

Stål Bjørkly

Keyword(s):

Preliminary Report ◽

Rating Scale ◽

Term Treatment ◽

Clinical Use ◽

Long Term Treatment ◽

Case Vignettes ◽

Secure Unit ◽

One Year ◽

Very High

This paper gives a description of the development and initial empirical testing of the Report Form for Aggressive Episodes, a behavioural rating scale used to measure displayed aggressive behaviour and the situational determinant(s) according to a list of 30 potential precipitants to aggression. Findings from a one-year study in a special secure unit for the long-term treatment of dangerous patients show very high rates of underreporting of aggressive episodes in ward journals and patient files compared to this scale. Illustrations of the clinical use of the scale are provided by scoring examples and two case vignettes.

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INFLUENCE OF LONG-TERM CYTOTOXIC CHEMOTHERAPY ON THE CONDITION OF PERIPHERAL VENOUS CHANNEL

EUREKA Health Sciences ◽

10.21303/2504-5679.2017.00331 ◽

2017 ◽

Vol 3 ◽

pp. 49-55

Author(s):

Tetiana Tkachuk

Keyword(s):

Cancer Patients ◽

Vascular Access ◽

Venous Access ◽

Term Treatment ◽

Cytotoxic Chemotherapy ◽

Cytotoxic Therapy ◽

Qualitative And Quantitative ◽

Long Term Treatment ◽

Term Administration

The necessity of long-term venous access in cancer patients appears at frequent and long-term courses of cytotoxic therapy. Peripheral veins of forearms are most often used for these aims. The conditions of peripheral venous channel in 32 cancer patients, who underwent the long-term treatment with antitumor preparations were analyzed in the article on own investigatory material. The methods of dopplerography, morphological and immunohystochemical studies were used. The qualitative and quantitative dopplerographic changes in forearm veins in different terms after chemotherapy start were revealed in most patients. The conclusion was made about unsuitability of forearm peripheral veins for the long term administration of cytostatics and the necessity to create the alternative vascular access that would correspond to the criteria of safety, reliability and long-term exploitation.

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