Association of Anaplastic Lymphoma Kinase (ALK) Immunohistochemical Expression with Endometrioid Endometrial Carcinoma (EEC) Histopathological Grading

2020 ◽  
Vol 11 (1) ◽  
pp. 254-257
Author(s):  
Irwandi Soekimin Delyuzar
Keyword(s):  
Endometrial Carcinoma ◽  
Anaplastic Lymphoma Kinase ◽  
Immunohistochemical Expression ◽  
Anaplastic Lymphoma ◽  
Endometrioid Endometrial Carcinoma ◽  
Histopathological Grading

Endometrioid Endometrial Carcinoma With Spindle Cells–Aberrant p16 and p53 Expression

2018 ◽  
Vol 27 (2) ◽  
pp. 203-207
Author(s):  
Snehal Sonawane ◽  
Osama Elfituri ◽  
Yanmin Zhang ◽  
Edgardo Yordan ◽  
Nicholas Ree
Keyword(s):  
Endometrial Carcinoma ◽  
Spindle Cell ◽  
Tumor Type ◽  
Immunohistochemical Expression ◽  
Cell Component ◽  
Diagnostic Dilemma ◽  
P53 Overexpression ◽  
P53 Expression ◽  
Spindle Cells ◽  
Endometrioid Endometrial Carcinoma

Endometrioid carcinoma is known for its diverse morphology and may pose a diagnostic dilemma when it presents with a spindle cell component. We present a case of a 65-year-old woman with postmenopausal bleeding. Physical examination showed a mass protruding from the external cervical os. The patient underwent biopsy followed by hysterectomy. Pathologic examination showed an endometrioid endometrial carcinoma with spindle cell differentiation arising in an endometrial polyp, which raised a variety of differential diagnoses. Prior reports of this tumor type showed nonaberrant immunohistochemical expression of p16 and p53. However, this case showed p16 and p53 overexpression indicating that there is a spectrum of these tumors.

Anaplastic Lymphoma Kinase in Human Cancer

2012 ◽  
Vol 17 (2) ◽  
pp. 123-143 ◽  
Author(s):  
Christina Schonherr ◽  
Bengt Hallberg ◽  
Ruth Palmer
Keyword(s):  
Anaplastic Lymphoma Kinase ◽  
Human Cancer ◽  
Anaplastic Lymphoma
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