Anaplastic Lymphoma Kinase in Human Cancer

2012 ◽  
Vol 17 (2) ◽  
pp. 123-143 ◽  
Author(s):  
Christina Schonherr ◽  
Bengt Hallberg ◽  
Ruth Palmer
Keyword(s):  
Anaplastic Lymphoma Kinase ◽  
Human Cancer ◽  
Anaplastic Lymphoma

scholarly journals Anaplastic lymphoma kinase in human cancer

2011 ◽  
Vol 47 (1) ◽  
pp. R11-R23 ◽  
Author(s):  
Antonella Barreca ◽  
Elena Lasorsa ◽  
Ludovica Riera ◽  
Rodolfo Machiorlatti ◽  
Roberto Piva ◽  
...  
Keyword(s):  
Anaplastic Lymphoma Kinase ◽  
Tyrosine Kinases ◽  
Fusion Proteins ◽  
Molecular Mechanisms ◽  
Cell Lymphoma ◽  
Human Cancer ◽  
Critical Role ◽  
Large Cell ◽  
Anaplastic Lymphoma ◽  
Alk Positive

The receptor tyrosine kinases (RTKs) play a critical role, controlling cell proliferation, survival, and differentiation of normal cells. Their pivotal function has been firmly established in the pathogenesis of many cancers as well. The anaplastic lymphoma kinase (ALK), a transmembrane RTK, originally identified in the nucleophosmin (NPM)–ALK chimera of anaplastic large cell lymphoma, has emerged as a novel tumorigenic player in several human cancers. In this review, we describe the expression of the ALK–RTK, its related fusion proteins, and their molecular mechanisms of activation. Novel tailored strategies are briefly illustrated for the treatment of ALK-positive neoplasms.

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