Association Between Body Mass Index (BMI) And Histopathologic Grade Of Endometrioid Endometrial Carcinoma (EEC)

Background: Incidence of endometrial carcinoma in Vojvodina is 15-20/100 000. In 75% cases, endometrial carcinoma is diagnosed in postmenopausal period. In 90 % of patients, the first clinical sign is postmenopausal bleeding. The aim of the study was to investigate clinical and histopathological characteristics in patients with postmenopausal bleeding. Methods: The study included 122 patients with postmenopausal bleeding. All of these patients underwent gynecological examination and vaginal ultrasound. We obtained materials for histopathological analysis by fractionate explorative curettage. Once we had definitive histopathological findings, we divided patients in two groups A (endometrial carcinoma) and B (benign changes). Results: We confirmed significant statistical differences between examined group A and B, including age (64.49 compared with 58.81 years), postmenopausal period (13.67 instead 9.11 years), and length of uterine corpus (6.41 instead 5.25 cm). Conclusion: Elderly women with longer postmenopausal interval and postmenopausal bleeding had increased risk for endometrial carcinoma. Measurement of endometrial thickness by transvaginal ultrasound appeared to be insufficient parameter for differentiating the benign from the malignant changes of endometrium. Patients with endometrial carcinoma had significantly longer corpus of uterus comparing to patients with benign changes. Body mass index was not found to be significant risk factor in development of endometrial carcinoma in the examined groups. Obesity was diagnosed in both groups, suggesting that increased body mass index is a risk factor for development of pathological changes in endometrium, which could lead to postmenopausal bleeding.

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A high body mass index is not a worse prognostic factor for endometrial carcinoma in a predominantly obese population

Clinical & Translational Oncology ◽

10.1007/s12094-012-0906-z ◽

2012 ◽

Vol 15 (3) ◽

pp. 243-247 ◽

Cited By ~ 9

Author(s):

Leonardo Saúl Lino-Silva ◽

David Cantú de León ◽

Rosa Angélica Salcedo-Hernández ◽

Claudia Cavazos-Saman ◽

María Delia Pérez-Montiel

Keyword(s):

Body Mass Index ◽

Prognostic Factor ◽

Endometrial Carcinoma ◽

Body Mass ◽

High Body Mass Index ◽

High Body ◽

Obese Population

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Role of age of incidence, parity, body mass index and socioeconomic class in endometrial carcinoma

International Journal of Reproduction Contraception Obstetrics and Gynecology ◽

10.18203/2320-1770.ijrcog20200373 ◽

2020 ◽

Vol 9 (2) ◽

pp. 762

Author(s):

Neha A. Nimbark

Keyword(s):

Body Mass Index ◽

Endometrial Carcinoma ◽

Body Mass ◽

Descriptive Statistics ◽

Age Group ◽

Socioeconomic Class ◽

Frequency Table ◽

Number Of Patients ◽

A Prospective Study

Background: Endometrial carcinoma is the most common gynecologial malignancy in world. The main aim is to study epidemiological factors of Ca body uterus in our hospital. The present study was designed to evaluate the age of incidence of carcinoma body uterus and study role of parity, body mass index and socioeconomic class in carcinoma body.Methods: This is a prospective study of 50 cases of endometrial carcinoma who were treated in a single unit of the hospital from April 2010 to March 2012 (2 years) conducted at the department of gynaecological oncology G. C. R. I., Ahmedabad. Observational study was done. All these data were combined and tabulated in frequency table simple percentage analysis is used for frequency and percentage analysis is applied to create a contingency table from the frequency distribution and represent the collected data for better understanding. Descriptive statistics were obtained for all variable.Results: Maximum number of patients were in age group of 50-59 years. Mean age was 58 years. Maximum patients were multiparous (54%). 4 patients were nulligravida (9%). 70% were overweight and obese. Majority of patients (72%) belong to middle and higher socio-economic class.Conclusions: It was noted that the incidence for ca endometrium is related to age, parity, BMI and socioeconomic class at our centre.

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Impact of Body Mass Index on Tumor Recurrence and Survival for Patients with Early Stage Endometrial Carcinoma after Adjuvant HDR Vaginal Cuff Brachytherapy

Brachytherapy ◽

10.1016/j.brachy.2013.01.109 ◽

2013 ◽

Vol 12 ◽

pp. S55-S56

Author(s):

Ibrahim Aref ◽

Omar H. Gayar ◽

Chad Cogan ◽

Mohamed A. Elshaikh

Keyword(s):

Body Mass Index ◽

Endometrial Carcinoma ◽

Body Mass ◽

Tumor Recurrence ◽

Early Stage ◽

Vaginal Cuff

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Frequency of Common Histopathological Findings among Patients Having Endometrial Thickness ≥5mm

10.53350/pjmhs211592236 ◽

2021 ◽

Vol 15 (9) ◽

pp. 2236-2238

Author(s):

Sadia Sharif ◽

Ayesha Sajjad ◽

Amna Kazi ◽

Ayesha Masood ◽

Nazish Javaid

Keyword(s):

Body Mass Index ◽

Endometrial Carcinoma ◽

Body Mass ◽

Rural Areas ◽

Endometrial Thickness ◽

Abnormal Uterine Bleeding ◽

Uterine Bleeding ◽

Transvaginal Ultrasonography ◽

Cross Sectional ◽

Histopathological Findings

Aim: To determine the frequency of common histopathological findings among patients having endometrial thickness >5mm and having atypical bleeding of uterus. Study design: Descriptive and cross sectional study Study settings: Department of Obstetrics & Gynaecology, Kishwer Fazal Teaching Hospital, Sheikhupura from 1st October 2020 to 31st March 2021. Methodology: One hundred and twenty patients were enrolled. Patients were aged between 45 to 60 years. Patient’s detailed demographics including age, parity, socioeconomic grade and body mass index were recorded post written informed consentreceival. Patients having endometrial thickness >5mm with abnormal uterine bleeding were included in this study.All the patients were undergone for transvaginal ultrasonography (TVS). Outcomes were histopathological findings observed. Results: The patients mean age was found to be 51.16±4.88 years with mean body mass index 27.24±4.63 kg/m2. Thirty five (29.2%) patients had parity I and 85 (70.8%) patients had parity II. Forty two (35%) patients had high socioeconomic status and 78(65%) were from low socio economic status. Majority of the patients 80(66.7%) were from rural areas. Secretory and proliferative were the most common histopathological findings found in (45.83% and 26.7%) patients. Frequency of endometrial carcinoma was found among 97(80.8%) cases. Conclusion: The most common histopathological findings were secretory and proliferative and frequency of endometrial carcinoma was too high. Endometrial anomalies can be excluded by transvaginal ultrasonography and is strongly useful in the evaluation of abnormal bleeding from the uterine. Keywords: Endometrial, Transvaginal ultrasonography, Uterine bleeding

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Body mass index, conversion rate and complications among patients undergoing robotic surgery for endometrial carcinoma

Journal of Robotic Surgery ◽

10.1007/s11701-015-0538-8 ◽

2015 ◽

Vol 9 (4) ◽

pp. 339-345 ◽

Cited By ~ 8

Author(s):

Mary J. Cunningham ◽

Esther Dorzin ◽

Loan Nguyen ◽

Elizabeth Anderson ◽

W. Douglas Bunn

Keyword(s):

Body Mass Index ◽

Robotic Surgery ◽

Endometrial Carcinoma ◽

Body Mass ◽

Conversion Rate

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The Association of Body Mass Index and Ki67 Values in Patients with Endometrial Carcinoma

Revista de Chimie ◽

10.37358/rc.19.9.7534 ◽

2019 ◽

Vol 70 (9) ◽

pp. 3277-3280

Author(s):

Alexandru Furau ◽

Marius Lucian Craina ◽

Cristian Furau ◽

Tudor Constantin Luca ◽

Bogdan Corneliu Andor ◽

...

Keyword(s):

Body Mass Index ◽

Endometrial Cancer ◽

Survival Rate ◽

Endometrial Carcinoma ◽

Body Mass ◽

Vaginal Bleeding ◽

Control Sample ◽

Ki 67 ◽

Her 2 ◽

Endometrial Cancers

Endometrial cancer begins in the layer of cells that form the lining (endometrium) of the uterus. Endometrial cancer is often detected at an early stage because it frequently produces abnormal vaginal bleeding, which prompts women to see their doctors. If endometrial cancer is discovered early, removing the uterus surgically often cures endometrial cancer. The study included all patients who had been evaluated for vaginal bleeding in Obstetrics and Gynecology Department of Clinical Emergency County Hospital, Timisoara between 2016-2018. Of the 195 cases of uterus scraping, 19 cases were labelled as malignant endometrial pathology. For the statistical analysis we calculated some descriptive statistics for the age parameter and the BMI (body mass index) parameter in our disease sample and we compared the BMI values to the BMI values from the control sample As well, we tested to see if there is an association between the Ki-67 values and the HER-2 / neu status in patients with or without endometrial carcinoma. In order to test the significance we applied a Mann -Whitney test, for a = 0.05 set as a confidence level. Unfortunately, in the case of our study group, type 1 endometrial cancers are found in only 5 cases, unlike other countries where most of endometrial cancers are diagnosed early (80% in the first stage) and the 5-year survival rate is about 95%. In any case, the 5-year survival rate is much lower if there is involvement of regional lymph nodes or distant metastasis (68% and 17%, respectively) - as in our case where all cases were classified as Stage III and IV. By running the statistical test we obtained extremely significant differences in the BMI of our patients (p[0.001), the diseased patients tend to have higher BMI values. As well, when we tested the possible association between the Ki-67 values and the HER-2 / neu status in our two groups (patients with or without endometrial carcinoma) we obtained extremely significant differences (p[0.001). The Ki-67 values are increasing proportionally with the carcinoma staging. An endometrial biopsy is the most commonly used test for endometrial cancer and is very accurate in postmenopausal women.

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