scholarly journals Diagnostic value of drug lymphocyte stimulation test and evaluation of diagnostic criteria for drug induced liver injury.

Kanzo ◽  
2001 ◽  
Vol 42 (9) ◽  
pp. 448-454 ◽  
Author(s):  
Masaaki WATANABE ◽  
Akitaka SHIBUYA ◽  
Akihiko SATOMICHI ◽  
Kouji ONO ◽  
Takeshi TSUCHIHASHI ◽  
...  
Keyword(s):  
Liver Injury ◽  
Diagnostic Criteria ◽  
Diagnostic Value ◽  
Stimulation Test ◽  
Lymphocyte Stimulation ◽  
Lymphocyte Stimulation Test ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Test And Evaluation ◽  
Drug Lymphocyte Stimulation Test

scholarly journals Diagnostic value of specific T cell reactivity to drugs in 95 cases of drug induced liver injury

Gut ◽  
1997 ◽  
Vol 41 (4) ◽  
pp. 534-540 ◽  
Author(s):  
V A J Maria ◽  
R M M Victorino
Keyword(s):  
T Cell ◽  
Liver Injury ◽  
Mononuclear Cells ◽  
Diagnostic Value ◽  
Drug Induced ◽  
Cell Reactivity ◽  
Peripheral Blood Mononuclear ◽  
Drug Induced Liver Injury ◽  
Prostaglandin Inhibitor ◽  
T Cell Reactivity

Background—Diagnosis of drug induced liver injury is usually based on a temporal relation between drug intake and clinical picture as well as on the exclusion of alternative causes. More precise diagnosis has been attempted by using in vitro specific T cell reactivity to drugs but the test has never reached general acceptability because of frequent negative results which could be explained, in part, by prostaglandin producing suppressor cells (PPSC).Aim—To analyse the diagnostic value of a modified test where lymphocyte responses to drugs are detected in the presence of a prostaglandin inhibitor.Patients—Ninety five patients with a clinical diagnosis of drug induced liver injury, 106 healthy controls, 35 individuals with recent exposure to the same drugs without adverse effects, and 15 patients with liver disease unrelated to drugs.Methods—Peripheral blood mononuclear cells (PBMC) were cultured in the presence of drugs alone and in the presence of drugs and a prostaglandin inhibitor. Responses were assessed by3H-thymidine incorporation in lymphocytes. Results were expressed as counts per minute and as stimulation indexes (SI).Results—When PBMC were stimulated with drugs alone, lymphocyte sensitisation to drugs (SI>2) was detected in 26% of the cases. This was noticeably increased (56%) when a prostaglandin inhibitor was added to the cultures. No reactivity was found in controls. In patients with possible sensitivity to several drugs, lymphocyte reactivity was detected to only one drug. The severity of the lesions, as assessed by aminotransferase concentrations and disease duration, was lower in patients with evidence of PPSC.Conclusions—This new approach is useful for the diagnosis of drug induced liver injury, particularly in patients exposed to more than one drug; furthermore, the presence of putative PPSC is associated with less severe forms of drug induced hepatitis.

scholarly journals Lymphocyte Stimulation Test with Tetrazolium-Based Colorimetric Assay for Diagnosis of Drug-Induced Allergic Hepatitis.

1994 ◽  
Vol 17 (7) ◽  
pp. 921-926 ◽  
Author(s):  
Tomoaki YOSHIMURA ◽  
Chikako KURITA ◽  
Futoshi YAMAZAKI ◽  
Satoshi NAKANO ◽  
Hiroichi NAGAI
Keyword(s):  
Colorimetric Assay ◽  
Stimulation Test ◽  
Lymphocyte Stimulation ◽  
Lymphocyte Stimulation Test ◽  
Drug Induced

Drug Lymphocyte Stimulation Test in the Diagnosis of Adverse Reactions to Antituberculosis Drugs

CHEST Journal ◽  
2008 ◽  
Vol 134 (5) ◽  
pp. 1027-1032 ◽  
Author(s):  
Yuzo Suzuki ◽  
Seiichi Miwa ◽  
Masahiro Shirai ◽  
Hisano Ohba ◽  
Miho Murakami ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Stimulation Test ◽  
Lymphocyte Stimulation ◽  
Lymphocyte Stimulation Test ◽  
Antituberculosis Drugs ◽  
Drug Lymphocyte Stimulation Test

Comparing the accuracy of three diagnostic criteria and a refined pathological scoring system in drug-induced liver injury: From suspected to definite

2019 ◽  
Author(s):  
Yiqi Liu ◽  
Ping Li ◽  
Fangfang Wang ◽  
Liang Liu ◽  
Yilian Zhang ◽  
...  
Keyword(s):  
Liver Injury ◽  
Diagnostic Criteria ◽  
Digestive Disease ◽  
Causality Assessment ◽  
Assessment Method ◽  
Operating Characteristics ◽  
Drug Induced ◽  
Drug Induced Liver Injury ◽  
Clinical Diagnostic ◽  
Clinical Diagnostic Criteria

Abstract Background Drug-induced liver injury(DILI) is difficult in diagnose, criteria used now are mostly based on history review. We tried to evaluate the value of these criteria and histopathology features in DILI to perform a method diagnosing DILI more definitely.Methods We enrolled 458 consecutive hospitalized DILI patients from 1st January 2012 to 31st December 2018, using Roussel-Uclaf Causality Assessment Method(RUCAM), Maria&Victorino scale (M&V) and Digestive Disease Week-Japan criterion(DDW-J) to perform the evaluation. A refined pathological scale was calculated and combined with those criteria using logistic regression analysis. Area under receiver operating characteristics(AUROC) were used to estimate diagnostic accuracy.Results The AUROC of the three clinical diagnostic criteria were 0.730 (95%CI:0.667-0.793), 0.793(95%CI:0.740-0.847) and 0.764(95%CI:0.702-0.826) respectively. The AUROC of the refined pathological scale combined with the three criteria were 0.843(95%CI:0.747-0.914), 0.907(95%CI:0.822-0.960) and 0.881(95%CI:0.790-0.942) respectively. In hepatocellular type, the AUROCs were 0.894(95%CI:0.787-0.959), 0.960(95%CI:0.857-0.994) and 0.940(95%CI:0.847-0.985); In cholestatic type, the AUROCs were 0.750(95%CI:0.466-0.931), 0.500(95%CI:0.239-0.761) and 0.500(95%CI:0.239-0.761); In mixed type, the AUROCs were 0.786(95%CI: 0.524-0.943), 0.869(95%CI:0.619-0.981) and 0.762(95%CI: 0.498 -0.930).Conclusion Combined with pathological scale can significantly improve the accuracy of clinical diagnostic criteria, no matter in alone or combined condition, M&V might be more accurate in diagnosing DILI from suspected patients.

Eosinophilic peritonitis induced by sucroferric oxyhydroxide

2020 ◽  
Vol 40 (4) ◽  
pp. 419-421
Author(s):  
Saori Minato ◽  
Haruhisa Miyazawa ◽  
Taisuke Kitano ◽  
Mitsutoshi Shindo ◽  
Kiyonori Ito ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Continuous Ambulatory Peritoneal Dialysis ◽  
Phosphate Binder ◽  
Immunosuppressive Agents ◽  
Stimulation Test ◽  
Lymphocyte Stimulation ◽  
Chronic Glomerulonephritis ◽  
Lymphocyte Stimulation Test ◽  
Drug Induced ◽  
Iron Based

A 49-year-old woman developed eosinophilic peritonitis 2 months after starting continuous ambulatory peritoneal dialysis because of congenital right kidney hypoplasia and chronic glomerulonephritis. This was shown to have been induced by sucroferric oxyhydroxide, an iron-based phosphate binder, using a drug-induced lymphocyte stimulation test. Her eosinophilic peritonitis was improved after stopping the administration of sucroferric oxyhydroxide without providing any immunosuppressive agents.

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