Background: Solid tumors are most common cause of death in the first fifteen years. In developed countries cancer is the leading cause of death from disease in children more than six month of age. The aim of this study was to assess: the relative frequency of the childhood tumor, the distribution of solid tumors of childhood in relation to age, sex of the patient, and histological types of the tumors over period (1992 -2015).Methods: Two thousand four hundreds and three cases of solid tumors of infancy and childhood has been studiedfor period from (1992-2015), 170 was a prospective cases where 2233 cases a retrospective. The study was carried out through histopathological examination of biopsies of patients attending major medical centres in Baghdad, Iraq.Results: Malignant neoplasms in descending order of frequency were, lymphoma (29.5%), central nervous system tumors (24.5%), soft tissue tumors (9.4%), Neuroblastoma (9.1%), wilms’ tumors, (7.4%), Bone tumors, (7.3%), Retinoblastoma (5.1%), Germ cell tumors, (3.5%), Liver tumors (0.2%), others (4.6). Males were more frequently affected with central nervous tumors (59.6%), Malignant lymphoma (69.5%), neuroblastoma (62%), Soft tissue tumors (60.3%), nephroblastoma (51.5%), retinoblastma (58.8%), liver tumor 81 and other miscellaneous tumors (59.6%) while females were more frequently effected with germ cell tumors 70.5% and bone tumors (53.9%). Central nervous system tumors reach a peak between (5-9) years whereas neuroblastoma, nephroblastoma, retinoblastoma germ cell tumors, liver tumors reach a peak between (0-4) years and malignant lymphoma, bone tumors and other – Miscellaneous – tumors reach a peak between (10-15 )years. Non Hodgkins lymphoma were the predominating lymphoma (62%), astrocytoma formed the majority of central nervous system tumors (44.6%) While rhabdomyosarcoma was the commonest histologic subtype of soft tissue tumors (76%) Ewing’s sarcoma was the commonest type of bone tumors (56%).Conclusions: A steady increase in the incidence rate of childhood tumors is noticed with a change in pattern from malignant lymphoma to CNS. tumors in the study period. A diagnostically important relationship exists between a particular type of pediatric tumors with age, sex and site.