The colonial framework introduced a central perspective into Palestinian studies in the context of addressing Zionism, Zionist relations with the Palestinian entity, and the creation of the question of Palestine. This chapter explores the rise and shifts of the Palestinian question from the Balfour Declaration to the “deal of the century.” Informed by a sociohistorical approach, the chapter goes through historical shifts and analyzes the Palestine question within relations of interplay and entanglement with the Zionist project and, later, with the state of Israel. It focuses on the sociological dimensions of the Palestine question at the intersection of settler colonialism, theology, and state-making, on the one hand, and indigenous resistance, national struggle, and pragmatism, on the other.