scholarly journals Study on the Role of Vitamin D in Systemic Lupus Erythematosus

2021 ◽  
Vol 4 (1) ◽  
pp. 23
Author(s):  
Jiadian Wang ◽  
Muzi Cui ◽  
Siyi Wang ◽  
Xiao Xue ◽  
Kerong Ren ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Lupus Erythematosus ◽  
Biological Effects ◽  
Research Progress ◽  
Target Cells ◽  
Systemic Lupus ◽  
Vitamin D Receptors

Vitamin D is a hormone precursor with multiple biological effects. It binds to vitamin D receptors on target cells. It is an important participant in the metabolism of calcium and phosphorus in vivo. It is closely related to cell cycle, cell proliferation, differentiation, apoptosis, signal transduction and immune regulation. Its role in the treatment of infection, tumor and even immune diseases has been gradually recognized and studied. Patients with systemic lupus erythematosus generally have decreased levels of active vitamin D, and low levels of vitamin D are associated with disease occurrence, disease activity and complications. In the past ten years, a large number of studies have been carried out on it globally to explore the role of vitamin D in the occurrence and development of systemic lupus erythematosus. This paper summarizes its recent research progress.

scholarly journals To Supplement or not to Supplement? The Rationale of Vitamin D Supplementation in Systemic Lupus Erythematosus

2018 ◽  
Vol 12 (1) ◽  
pp. 226-247 ◽  
Author(s):  
Alessandra Nerviani ◽  
Daniele Mauro ◽  
Michele Gilio ◽  
Rosa Daniela Grembiale ◽  
Myles J. Lewis
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Lupus Erythematosus ◽  
Clinical Manifestations ◽  
Vitamin D Supplementation ◽  
Current Evidence ◽  
Systemic Lupus ◽  
Vitamin D Receptors ◽  
Vitamin D Levels

Background: Systemic Lupus Erythematosus (SLE) is a systemic autoimmune disease characterised by abnormal activation of the immune system, chronic inflammation and organ damage. Lupus patients are more prone to be vitamin D deficient. However, current evidence is not conclusive with regards to the role played by vitamin D in SLE development, progression, and clinical manifestations. Objective: Here, we will summarise the current knowledge about vitamin D deficiency prevalence, risk factors, molecular effects, and potential pathogenic role in SLE. We will focus on the link between vitamin D deficiency and lupus clinical manifestations, and on the clinical trials assessing the effects of vitamin D supplementation in SLE. Method: A detailed literature search was performed exploiting the available databases, using “vitamin D and lupus/SLE” as keywords. The relevant interventional trials published over the last decade have been considered and the results are reported here. Conclusion: Several immune cells express vitamin D receptors. Thus, an immunomodulatory role for vitamin D in lupus is plausible. Numerous observational studies have investigated the relationship between vitamin D levels and clinical/serological manifestations of SLE with contrasting results. Negative correlations between vitamin D levels and disease activity, fatigue, renal and cardiovascular disease, and anti-dsDNA titres have been described but not conclusively accepted. In experimental models of lupus, vitamin D supplementation can improve the disease. Interventional trials have assessed the potential therapeutic value of vitamin D in SLE, but further larger studies are needed.

The essential role of costimulatory molecules in systemic lupus erythematosus

Lupus ◽  
2019 ◽  
Vol 28 (5) ◽  
pp. 575-582 ◽  
Author(s):  
Z X Xiao ◽  
N Olsen ◽  
S G Zheng
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Autoimmune Diseases ◽  
Lupus Erythematosus ◽  
Biological Effects ◽  
Critical Role ◽  
Chronic Inflammatory Disease ◽  
Costimulatory Molecules ◽  
Systemic Lupus ◽  
System Disorder

Systemic lupus erythematosus (SLE) is a chronic inflammatory disease with immune system disorder mediated through complex autoimmune pathways that involve immune cells, nonimmune cells, cytokines, chemokines, as well as costimulatory molecules. Costimulatory signals play a critical role in initiating, maintaining and regulating immune reactions, and these include ligands and receptors and their interactions involving multiple types of signal information. Dysfunction of costimulatory factors results in complicated abnormal immune responses, with biological effects and eventually, clinical autoimmune diseases. Here we outline what is known about various roles that costimulatory families including the B7 family and tumor necrosis factor super family play in SLE. The aim of this review is to understand the possible association of costimulation with autoimmune diseases, especially SLE, and to explore possible therapeutic target(s) of costimulatory molecules and pathways that might be used to develop therapeutic approaches for patients with these conditions.

Role of vitamin D in endothelial repair mechanisms in systemic lupus erythematosus

The Lancet ◽  
2014 ◽  
Vol 383 ◽  
pp. S89 ◽  
Author(s):  
John Reynolds ◽  
David Ray ◽  
Terence O'Neill ◽  
M Yvonne Alexander ◽  
Ian Bruce
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Endothelial Repair ◽  
Repair Mechanisms

scholarly journals Role of Vitamin D in Systemic Lupus Erythematosus

2014 ◽  
Vol 2 (4) ◽  
pp. 662-667 ◽  
Author(s):  
Rada Miskovic ◽  
Aleksandra Plavsic ◽  
Jasna Bolpacic ◽  
Sanvila Raskovic ◽  
Mirjana Bogic
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Lupus Erythematosus ◽  
Animal Studies ◽  
Potential Role ◽  
Vitamin D Supplementation ◽  
Vitamin D Status ◽  
Systemic Lupus

Vitamin D is a steroid hormone that in addition to its well known role in the metabolism of calcium and phosphorus exerts immunoregulatory properties. Data from animal studies and from prospective clinical trials on patients with rheumatoid arthritis, multiple sclerosis and type 1 diabetes point to the potential role of vitamin D as important environmental factor in the development of autoimmune diseases. Such role of vitamin D in systemic lupus erythematosus (SLE) has not yet been sufficiently studied. This review shows the sources, metabolism and mechanism of action of vitamin D, its effect on the cells of the immune system, prevalence and causes of vitamin D deficiency in patients with SLE, the link between vitamin D status and disease activity as well as recommendations for vitamin D supplementation.

scholarly journals THE IMMUNOMODULATORY ROLE OF VITAMIN D IN SYSTEMIC LUPUS ERYTHEMATOSUS: AN INTEGRATING LITERATURE REVIEW

2018 ◽  
Vol 2 (4) ◽  
pp. 88-99
Author(s):  
Lucas Tavares Cruz de Albuquerque ◽  
Caroline Pereira Modesto ◽  
Pedro De Sousa Leite ◽  
Ana Aurélia Tavares da Cruz ◽  
Djailson Ricardo Malheiro
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Lupus Erythematosus ◽  
Inflammatory Markers ◽  
Scientific Literature ◽  
Adequate Intake ◽  
Systemic Lupus ◽  
The Subject

Vitamin D, conceptually, is a pre-hormone. Many studies have shown that the vitamin D deficiency may be associated to a higher incidence of autoimmune diseases, including Systemic Lupus Erythematosus. So, this work’s purpose is identify what the scientific literature approaches about the vitamin D, highlighting its immunomodulatory role with the Systemic Lupus Erythematosus. We used the article survey that ran upon the subject in the Medline, Scielo and Lilacs databases with the descriptors: vitamin D, Systemic Lupus Erythematosus and autoimmune disease. The selected articles pointed out higher prevalence in the vitamin D deficiency and insufficiency in Lupus patients. In these, the supplementation appeared to improve the disease activity and inflammatory markers and shows a tendency for subsequent clinical improvement. However, there is a lack of adequate intake guidelines. In this way, researches about the best dosage of vitamin D are needed for these patients in order to improve their condition.

The beneficial role of vitamin D in systemic lupus erythematosus (SLE)

2012 ◽  
Vol 31 (10) ◽  
pp. 1423-1435 ◽  
Author(s):  
Khanh vinh quốc Lương ◽  
Lan Thi Hoàng Nguyễn
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Beneficial Role

scholarly journals Role of vitamin D deficiency in systemic lupus erythematosus incidence and aggravation

2017 ◽  
Vol 9 (1) ◽  
Author(s):  
Tohid Hassanalilou ◽  
Leila Khalili ◽  
Saeid Ghavamzadeh ◽  
Ali Shokri ◽  
Laleh Payahoo ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Lupus Erythematosus ◽  
Systemic Lupus
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