Peculiarities of the Anterior Surface of the Eye in Patients with Newly Diagnosed Primary Open-Angle Glaucoma

2021 ◽  
pp. 26-32
Author(s):  
Natalia M. Veselovska ◽  
Olga G. Pyatiizbyantseva ◽  
Inna B. Zaporozhchenko ◽  
Zoya F. Veselovska
Keyword(s):  
Dry Eye ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Front Surface ◽  
Dry Eye Syndrome ◽  
Open Angle ◽  
Anterior Surface ◽  
Newly Diagnosed ◽  
Blurred Vision ◽  
Preservative Free

The aim. To conduct an analysis of the anterior surface of the eye in patients with the newly diagnosed primary open-angle glaucoma in order to choose treatment with or without preservative. Materials and methods. We evaluated the front surface of the eye in 46 patients (92 eyes) diagnosed with primary open-angle glaucoma: 20 men and 26 women aged from 58 to 80 years. The anterior surface of the eye was examined using an analyzer of the anterior eye. Results. The signs of previously diagnosed dry eye syndrome (DES) with various manifestations of dysfunction of meibomian glands and complaints about dry eyes, foreign body sensation, lacrimation and blurred vision were reported in 39 patients (85%). Based on the examination results, preservative-free topical hypotensive medications were recommended for these 39 patients. Conclusion. In order to preserve visual functions and quality of life in patients with newly diagnosed POAG, it is advisable to conduct a preliminary assessment of the condition of the anterior surface of the eye when prescribing drug therapy in order to rationalize the choice of first-line drugs with or without preservative in accordance with the European recommendations of Diagnosis and Treatment for glaucoma. Keywords: preservative-free medications, dry eye syndrome, primary open-angle glaucoma.

scholarly journals The efficiency of monotherapy of patients with primary open-angle glaucoma with Bimatoprost 0.03 % (Bimoptic)

2018 ◽  
Vol 11 (4) ◽  
pp. 75-79
Author(s):  
S. A. Korotkikh ◽  
G. V. Zhiborkin ◽  
E. S. Knyazeva ◽  
L. V. Rusakova
Keyword(s):  
Carbonic Anhydrase ◽  
Dry Eye ◽  
Adverse Reactions ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Hypotensive Effect ◽  
Carbonic Anhydrase Inhibitor ◽  
Dry Eye Syndrome ◽  
Open Angle ◽  
Newly Diagnosed

Purpose: to evaluate the hypotensive effect and adverse reactions occurrence in patients with primary open angle glaucoma (POAG) who received Bimatoprost (Bimoptic Rompharm) monotherapy.Materials and methods. 46 patients (75 eyes) with stage I–III POAG were prescribed bimatoprost therapy. Of these, 16 patients (20 eyes) had newly diagnosed glaucoma, 15 patients (27 eyes) previously received treatment with prostaglandin analogs (APG — Latanoprost), and 15 patients (28 eyes) previously received treatment with a fixed combination (FC) composed of timolol B-blocker and brinzolamide carbonic anhydrase inhibitor. The reason for transferring the patient from therapy with APG and FC to monotherapy with Bimatoprost was insufficient hypotensive effect of APG/FC therapy, and the presence of dry eye syndrome of varying severity in most patients. The results were evaluated after 1, 4 and 12 weeks of Bimatoprost therapy. Results. A hypotensive effect of monotherapy with Bimatoprost was confirmed in patients with newly diagnosed POAG. An additional hypotensive effect was revealed when patients with POAG were transferred from APG and FC therapy to monotherapy with Bimatoprost. Adverse reactions: mild and moderate hyperaemia, periorbital manifestations such as skin pigmentation, deepening of upper eyelid folds, narrowing of the palpebral fissure (ptosis) were noted, respectively, in 8, 6.7, 1.3, 2.7, 2.7 % of cases respectively, but did not require a discontinuation of the therapy in any patient. Eyelash growth was noted by 3 patients (4 %). This effect was not considered to be a side effect, since none of the patients bothered. In 47 % of patients who had previously received APG and FC therapy and had dry eye syndrome of varying severity, objective and subjective positive changes relating to dry eye syndrome was noted. A positive dynamic of morphometric parameters of the optic nerve and cells of the retinal ganglion complex was revealed in patients of all groups of study.Conclusion. Monotherapy with Bimatoprost can be recommended as therapy of choice for patients with newly diagnosed glaucoma, and those previously receiving antihypertensive therapy with PGAs or fixed combinations (-blocker + carbonic anhydrase inhibitor) including those having dry eye  syndrome of varying severity.

The incidence of dry eye syndrome depending on the duration of antihypertensive drops use in patients with primary open-angle glaucoma

Reflection ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 56-61
Author(s):  
A.D. Pilipenko ◽  
◽  
R.A. Burya ◽  
A.V. Romanova ◽  
◽  
...  
Keyword(s):  
Antihypertensive Therapy ◽  
Dry Eye ◽  
Ocular Surface ◽  
Primary Open Angle Glaucoma ◽  
Antihypertensive Drugs ◽  
Open Angle Glaucoma ◽  
Dry Eye Syndrome ◽  
Open Angle ◽  
Inclusion Criteria ◽  
Systemic Pathology

Aim. To conduct a clinical assessment of the incidence of dry eye syndrome (DES) in patients with primary open-angle glaucoma (POAG), depending on the timing of the use of local antihypertensive therapy. Methods. The main group included 45 patients (45 eyes) with POAG. Inclusion criteria - use of local antihypertensive therapy for at least one month; absence of previous laser and microsurgery operations, systemic pathology that can cause DES (thyroid lesions, diabetes mellitus, autoimmune and rheumatoid diseases). The patients’ age averaged 61.2±8.7 years (from 47 to 82 years). There were 29 men and 16 women. The design of the work consisted of a comparative assessment of the frequency of DES formation in the studied groups and subgroups, as well as the degree of its severity. Results. The results of the study showed that with an increase in the duration of the use of local antihypertensive drugs by patients with POAG the incidence of DES development increases. Moderate changes in the studied functional parameters of the ocular surface were recorded as early as 1-3 years from the start of antihypertensive therapy. Especially often DES was formed in the 3rd subgroup and proceeded in more severe clinical forms. Conclusion. The initial statistically insignificant changes in the indicators of the state of the ocular surface in patients with POAG using local antihypertensive therapy took place at the time of their instillation from 1 to 3 years. Most often, according to our data, DES developed in patients with POAG after three years of using antihypertensive drugs (9 out of 15 patients). Key words: dry eye syndrome; glaucoma; antihypertensive therapy.

Relationship between duration of antihypertensive regimen and incidence of dry eye syndrome in patients with primary open-angle glaucoma

2021 ◽  
pp. 75-78
Author(s):  
A.D. Pilipenko ◽  
◽  
R.A. Burya ◽  
A.V. Romanova ◽  
◽  
...  
Keyword(s):  
Antihypertensive Therapy ◽  
Dry Eye ◽  
Primary Open Angle Glaucoma ◽  
Comparison Group ◽  
Open Angle Glaucoma ◽  
Main Group ◽  
Dry Eye Syndrome ◽  
Open Angle ◽  
Antihypertensive Regimen ◽  
Initial Symptoms

Purpose. To study the incidence of dry eye syndrome (DES) in patients with primary open-angle glaucoma (POAG), depending on the duration of the use of local antihypertensive therapy. Material and methods. The material for the study was patients who were examined in the treatment and diagnostic department of the Khabarovsk branch the S. Fyodorov Eye Microsurgery Federal State Institution with a confirmed clinical diagnosis of POAG. The main group included 45 patients with a duration of antihypertensive therapy of 1 month or more. The comparison group consisted of 15 patients with newly diagnosed POAG. The period of use of antihypertensive therapy in them did not exceed one month. Depending on the experience of using antihypertensive therapy, the patients of the main group were divided into 3 subgroups. All were questioned using the DEQ-5 dry eye questionnaire, Schirmer I, II and Norn's tests, objective examination of the anterior segment of the eyes. The analysis of the detection and severity of DES among patients with POAG was carried out, taking into account the experience of using the antihypertensive regimen. Results. According to the questionnaire, 26 patients (58%) of the main group presented complaints typical of DES, while in the comparison group only 3 patients (20%) presented them (p<0.05). There was also a tendency towards a decrease in the total and main type of tear production in the main group according to the results of Schirmer's tests I and II – 10.9±1.04 mm and 7.7±0.48 mm versus 13.9±2.5 mm and 10, 2±2.1 mm in the comparison group (p>0.05). The stability of the tear film, according to Norn's test, also differed: 8.2±0.35 sec. and 9.5±1.8 sec. in the main and comparison group, respectively (p> 0.05). Conclusion. The initial symptoms of xerosis of the ocular surface are recorded in the period from 1 to 3 years from the beginning of the use of antihypertensive drugs and increase in proportion to the increase in the length of the disease. Key words: dry eye syndrome, glaucoma, antihypertensive therapy.

Dry eye syndrome in patients with primary open-angle glaucoma

2015 ◽  
Vol 131 (3) ◽  
pp. 22
Author(s):  
E. V. Boyko ◽  
I. L. Simakova ◽  
D. Yu. Yakushev ◽  
S. A. Ignat'ev ◽  
I. B. Alekseev ◽  
...  
Keyword(s):  
Dry Eye ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Dry Eye Syndrome ◽  
Open Angle

scholarly journals Use of the drug in patients tealoz primary open angle glaucoma syndrome "dry eye"

2016 ◽  
Vol 9 (1) ◽  
pp. 73-76
Author(s):  
Larisa I Ushakova ◽  
Sergey V Balalin
Keyword(s):  
Dry Eye ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Dry Eye Syndrome ◽  
Control Group ◽  
Open Angle ◽  
Schirmer’S Test ◽  
Clearance Test

Dry eye syndrome is frequently observed in patients with primary open-angle glaucoma with prolonged pharmacological hypotensive treatment. Purpose: To analyze the effectiveness Tealoz the drug in patients with primary open-angle glaucoma in the treatment of the syndrome of "dry eye." Materials end Methods: the effectiveness of the drug Tealoz studied in 29 patients with primary open-angle glaucoma (43 eyes) in the treatment of the syndrome of "dry eye." The control group consisted of 34 patients with primary open-angle glaucoma (54 eyes). Results: during treatment Tealoz noted improvement in Schirmer's test values in 23.3% of cases (10 eyes), Norn sample in 18.6% cases (8 eyes), clearance test in 25.6% of cases (11 eyes), LIPCOF test in 16.3% cases (7 eyes). No significant changes in the results of the samples were found in the control group. Conclusions: Tealoz drug effective in the treatment of dry eye syndrome in patients with primary open-angle glaucoma.

scholarly journals Influence of BAK-Preserved Prostaglandin Analog Treatment on the Ocular Surface Health in Patients with Newly Diagnosed Primary Open-Angle Glaucoma

2013 ◽  
Vol 2013 ◽  
pp. 1-7 ◽  
Author(s):  
Martina Tomić ◽  
Snježana Kaštelan ◽  
Kata Metež Soldo ◽  
Jasminka Salopek-Rabatić
Keyword(s):  
Intraocular Pressure ◽  
Ocular Surface ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Final Visit ◽  
Open Angle ◽  
Newly Diagnosed ◽  
Prostaglandin Analog ◽  
Ocular Surface Health

Purpose. Primary open-angle glaucoma (POAG), a chronic, degenerative optic neuropathy, requires persistent decrease of intraocular pressure so as to prevent visual impairment and blindness. However, long-term use of topical ocular medications may affect ocular surface health. Purpose of this study was to evaluate the influence of BAK-preserved prostaglandin analog treatment on the ocular surface health in patients with newly diagnosed POAG.Methods. 40 newly diagnosed POAG patients were included in this prospective study. Intraocular pressure (IOP), tear break-up time (TBUT), and ocular surface disease index (OSDI) were assessed at baseline and 3-month after starting treatment with BAK-preserved travoprost 0.004%.Results. IOP decreased in all patients from baseline to 3-month final visit (23.80 ± 1.73 mmHg versus 16.78 ± 1.27 mmHg;P<0.001). Mean TBUT decreased from11.70±1.86seconds at baseline to 8.30 ± 1.29 seconds at 3-month final visit (<0.001). Mean OSDI score increased from 31.63 ± 18.48 to 44.41 ± 16.48 (P<0.001).Conclusions. This study showed that BAK-preserved travoprost 0.004% is an effective medication in newly diagnosed POAG patients, but its long-term use may negatively influence ocular surface health by disrupting the tear film stability. Further studies are needed to better understand the clinical effects of different preservative types and concentrations on the ocular surface.

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