The aim: of the study is to determine the frequency of polymorphism of estrogen receptor gene ESR1 (T-397C variant) in patients with premenstrual syndrome.
Materials and methods: 50 women with diagnosis of premenstrual syndrome (the basic group) and 25 persons without it (the control group) were examined. Polymerase
chain reaction was used to study T-397C polymorphism of estrogen receptor gene ESR1.
Results: There was no significant difference in allele and genotype rates of ESR1 gene between persons with premenstrual syndrome and controls. TT genotype was determined
in 24.0 % women in the control group and 24 % of patients in basic group (OR=1.00, 95 % CI=0.32-3.08, p=1.00), TC genotype – in 52.0 % and 46.0 % of individuals respectively
(OR=0.79, 95 % CI=0.30-2.06, p=0.62), CC genotype – 24.0 % and 30.0 % of women respectively (OR=1.36, 95 % CI=0.45-4.07, p=0.59). Also, the frequency of T allele and
C allele was similar in individuals with pathology and healthy women. There was no significant difference in allele and genotype rates of T-397C variant of ESR1 gene between
patients with mild and severe forms of premenstrual syndrome and controls.
Conclusions: There is no association of T-397C polymorphic variant of estrogen receptor gene ESR1 with the development of premenstrual syndrome.
Effect of estrogen receptor gene ESR1 polymorphism on development of premenstrual syndrome
