Viral Hepatitis B Seroprevalence Among Pregnant Women in Tlemcen

Hepatitis B is most common among young people, which is explained by the ways of infection – parenteral, sexual and vertical. Mother-to-child transmission is the main route of infection for children in areas where the hepatitis B virus (HBV) is endemic.The available current data on the course and outcomes of chronic viral hepatitis B are contradictory in pregnant women. Some authors argue that the exacerbation of chronic hepatitis B is more common in the first and third trimesters in pregnant women, and with an increase in gestation, there is a deterioration in liver function and an increased risk of fulminant liver failure. Other researchers note a more severe course in the second half of pregnancy or in the first months after delivery.High replication of the virus increases the frequency of gestational diabetes mellitus, hemostatic disorders, the threat of termination of pregnancy, gestosis, fetoplacental insufficiency, risk of bleeding in childbirth, premature birth, untimely discharge of amniotic fluid, and the birth of premature babies.Children become chronic carriers of HBsAd in neonatal hepatitis. These findings suggest that transplacental infection before birth may be a mechanism contributing to higher rates of failed prevention in newborns born to women with a high viral load.We could not find data on the features of the course and outcomes of viral hepatitis D in pregnant women in the available sources,. At the same time, it is known that mixed infection is more severe.Polymorphisms of genes associated with the regulation of the state of the vascular wall can have a significant impact on the course of infection.The high prevalence of hepatitis D infection in different parts of the world indicates the need for a comprehensive study of this disease, followed by the development of special programs for the prevention, early diagnosis and treatment of hepatitis B and D in pregnant women.

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Regional and Ethnic Aspects of Viral Hepatitis B among Pregnant Women

Central European Journal of Public Health ◽

10.21101/cejph.a3800 ◽

2013 ◽

Vol 21 (1) ◽

pp. 22-25 ◽

Cited By ~ 6

Author(s):

Pavol Kristian ◽

Zuzana Dankulincová Veselská ◽

Zuzana Paraličová ◽

Peter Jarčuška ◽

Ladislav Virág ◽

...

Keyword(s):

Hepatitis B ◽

Pregnant Women ◽

Viral Hepatitis ◽

Viral Hepatitis B

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Regional and ethnical aspects of viral hepatitis B in pregnant women in Slovakia

International Journal of Infectious Diseases ◽

10.1016/j.ijid.2010.02.1994 ◽

2010 ◽

Vol 14 ◽

pp. e227-e228

Author(s):

P. Kristian ◽

I. Schreter ◽

Z. Paralicova ◽

P. Jarcuska ◽

L. Siegfried ◽

...

Keyword(s):

Hepatitis B ◽

Pregnant Women ◽

Viral Hepatitis ◽

Viral Hepatitis B

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Possibilities of the use of shear wave elastography of the liver in pregnant women infected with viral hepatitis B and C

Kazan medical journal ◽

10.17816/kmj2019-345 ◽

2019 ◽

Vol 100 (2) ◽

pp. 345-350

Author(s):

E G Saryeva

Keyword(s):

Hepatitis B ◽

Viral Infection ◽

Pregnant Women ◽

Viral Hepatitis ◽

Shear Wave ◽

Clinical Medicine ◽

Shear Wave Elastography ◽

Average Density ◽

Viral Hepatitis B ◽

Medical University

Aim. To determine the diagnostic possibilities of using liver shear wave elastography in pregnant women with hepatitis B and C viral infection. Methods. The study included 87 women with hepatitis B and C viral infections admitted to the Center of Clinical Medicine №1 and Educational and Therapeutic Clinic of Azerbaijan Medical University (basis of the department of obstetrics and gynecology 2 of Azerbaijan Medical University) in 2016 to 2017 aged 18-45 (average age 31.4±7.1 years), and 50 uninfected women with physiological pregnancy matched by the age (average age 30.6±6.8 years). Infected women were divided into two groups: 70 pregnant women (group 1) and 17 women (group 2), who were non-pregnant at the time of the study (average age 29.8±7.2 and 30.9±6.7 years, respectively). Women with physiological course of pregnancy were included into group 3 (average age 30.6±6.8 years). Groups of pregnant patients were matched by age, gestation age and parity (p ˃0.05). All patients underwent clinical and biochemical analyses and shear wave elastography of the liver. The obtained data were processed using the methods of variation statistics with calculation of mean and standard error (M±m), Mann-Whitney U-test, Spearman's rank correlation coefficient. Results. In 52.9±6% of the examined pregnant women with viral hepatitis, hepatitis B was identified, in 47.1±6% - hepatitis C. According to the results of shear wave elastography, the average density of the liver in these patients was 7.2±1.0 kPa. An increase in liver density in pregnant women with viral hepatitis was not accompanied by changes in the size of the liver (only 1 patient had hepatomegaly). In 71.4±5.4% of the patients, F1 degree was revealed, in 20.0±4.8% - F2, in 5.7±2.8% - F3, in 2.9±2.0% - F4. İn comparison with infected patients without pregnancy, pregnant women with viral hepatitis B and C had more severe degree of fibrosis [F1 was significantly less frequent (p ˂0.05), and F2 was significantly more frequent (p ˂0.05)], and also had F4 degree, which was not observed in non-pregnant. In infected pregnant women, there was a positive correlation between liver echogenicity and density of its tissues (p=0.495; p <0.001). Conclusion. In pregnant women with hepatitis B and C viral infection, the use of shear wave elastography allows detecting various degrees of liver fibrosis by a non-invasive method in the early stages, even in the absence of marked clinical and laboratory changes.

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THE TACTICS OF ANTIVIRAL THERAPY FOR CHRONIC VIRAL HEPATITIS B IN PREGNANT WOMEN

Technology transfer innovative solutions in medicine ◽

10.21303/2585-663.2020.001478 ◽

2020 ◽

pp. 14-16

Author(s):

Yuliia Mudra

Keyword(s):

Hepatitis B Virus ◽

Hepatitis B ◽

Pregnant Women ◽

Viral Hepatitis ◽

Antiviral Therapy ◽

Late Pregnancy ◽

Chronic Viral Hepatitis ◽

Sharp Drop ◽

B Virus ◽

Viral Hepatitis B

The aim of the study. Analysis of tactics of antiviral therapy for chronic viral hepatitis b in pregnant women. Methods. Theoretical analysis of scientific literature; analysis and generalization. Statistics and comparisons. Classification of theoretical material and development of recommendations. Research results. Today, there are about 2 billion people in the world ill with a chronic infection caused by the hepatitis B virus, 350 million of whom suffer from chronic hepatitis B, and most are asymptomatic carriers of the Australian antigen (HBsAg). Up to 50 % of all new cases of hepatitis B virus infection are due to vertical infection. Despite the lack of increase in viral load during pregnancy, alanine aminotransferase tends to increase in late pregnancy and in the postpartum period. A sharp drop in postpartum corticosteroids may create favourable conditions for hepatitis B virus activation. It is emphasized that the current treatment of hepatitis B virus includes the use of antiviral drugs, where Peg-IFN is absolutely contraindicated in pregnancy, lamivudine and entecavir are classified by the FDA as category C, and tenofovir and telbivudine are classified as category B. During pregnancy, it is recommended to use mainly category B drugs. Conclusions. The use of antiviral therapy in combination with immunoprophylaxis of new-borns is the optimal strategy for implementation as a universal program, as the success of such an intervention can make a significant contribution to achieving the ultimate goal of global elimination of hepatitis B virus.

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