scholarly journals The relationship between acute arterial occlusions and the stage of peripheral arterial disease according to the Fontaine Classification

2018 ◽  
Vol 22 (2) ◽  
pp. 214-221
Author(s):  
İbrahim Murat ÖZGÜLER ◽  
Latif ÜSTÜNEL ◽  
Ayhan UYSAL
Keyword(s):  
Peripheral Arterial Disease ◽  
Arterial Disease ◽  
Peripheral Arterial ◽  
Fontaine Classification ◽  
The Relationship

The relationship between vitamin K and peripheral arterial disease

2016 ◽  
Vol 252 ◽  
pp. 15-20 ◽  
Author(s):  
Linda E.T. Vissers ◽  
Geertje W. Dalmeijer ◽  
Jolanda M.A. Boer ◽  
W.M. Monique Verschuren ◽  
Yvonne T. van der Schouw ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Vitamin K ◽  
Arterial Disease ◽  
Peripheral Arterial ◽  
The Relationship

scholarly journals Increased Elastin Degradation in Pseudoxanthoma Elasticum Is Associated with Peripheral Arterial Disease Independent of Calcification

2020 ◽  
Vol 9 (9) ◽  
pp. 2771
Author(s):  
Jonas W. Bartstra ◽  
Wilko Spiering ◽  
Jody M. W. van den Ouweland ◽  
Willem P. T. M. Mali ◽  
Rob Janssen ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Ankle Brachial Index ◽  
Pseudoxanthoma Elasticum ◽  
Arterial Disease ◽  
Arterial Calcification ◽  
Elastin Degradation ◽  
Liquid Chromatography Tandem Mass ◽  
Peripheral Arterial ◽  
Fontaine Classification

Pseudoxanthoma elasticum (PXE) results in extensive fragmentation and calcification of elastin fibers in the peripheral arteries, which results in peripheral arterial disease (PAD). Current research focuses on the role of calcifications in the pathogenesis of PXE. Elastin degradation and calcification are shown to interact and may amplify each other. This study aims to compare plasma desmosines, a measure of elastin degradation, between PXE patients and controls and to investigate the association between desmosines and (1) arterial calcification, (2) PAD, and (3) PAD independent of arterial calcification in PXE. Plasma desmosines were quantified with liquid chromatography-tandem mass spectrometry in 93 PXE patients and 72 controls. In PXE patients, arterial calcification mass was quantified on CT scans. The ankle brachial index (ABI) after treadmill test was used to analyze PAD, defined as ABI < 0.9, and the Fontaine classification was used to distinguish symptomatic and asymptomatic PAD. Regression models were built to test the association between desmosines and arterial calcification and arterial functioning in PXE. PXE patients had higher desmosines than controls (350 (290–410) ng/L vs. 320 (280–360) ng/L, p = 0.02). After adjustment for age, sex, body mass index, smoking, type 2 diabetes mellitus, and pulmonary abnormalities, desmosines were associated with worse ABI (β (95%CI): −68 (−132; −3) ng/L), more PAD (β (95%CI): 40 (7; 73) ng/L), and higher Fontaine classification (β (95%CI): 30 (6; 53) ng/L), but not with arterial calcification mass. Lower ABI was associated with higher desmosines, independent from arterial calcification mass (β (95%CI): −0.71(−1.39; −0.01)). Elastin degradation is accelerated in PXE patients compared to controls. The association between desmosines and ABI emphasizes the role of elastin degradation in PAD in PXE. Our results suggest that both elastin degradation and arterial calcification independently contribute to PAD in PXE.

The Relationship Between Serum Bilirubin Levels and Peripheral Arterial Disease and Gender Difference in Patients With Hypertension: BEST Study

Angiology ◽  
2020 ◽  
Vol 71 (4) ◽  
pp. 340-348
Author(s):  
Yang Lan ◽  
Huan Liu ◽  
Jinbo Liu ◽  
Hongwei Zhao ◽  
Hongyu Wang
Keyword(s):  
Peripheral Arterial Disease ◽  
Total Bilirubin ◽  
Serum Bilirubin ◽  
Venous Blood ◽  
Ankle Brachial Index ◽  
Arterial Disease ◽  
Serum Total Bilirubin ◽  
And Gender ◽  
Peripheral Arterial ◽  
The Relationship

We evaluated the relationship between serum bilirubin levels and ankle-brachial index (ABI) to determine whether gender affected the relationship between bilirubin levels and peripheral arterial disease (PAD) in patients with hypertension. A total of 543 patients were included in our studies (78 patients with PAD and 465 without PAD). Peripheral arterial disease was defined as ABI <0.90 for either and/or both sides. Serum bilirubin levels were measured with a vanadate oxidation method by using fasting venous blood samples. Serum total bilirubin (TBiL) and direct bilirubin (DBiL) levels were higher in males compared with females (both P < .05). Total bilirubin and DBiL were significantly lower in the PAD group. After adjustment for cardiovascular risk factors, PAD was independently negatively related to TBiL and DBiL, with odds ratios (OR) 0.914 (95% confidence interval [CI]: 0.845-0.990) and 0.748 (95% CI: 0.572-0.977). In addition, there was a relationship between PAD and bilirubin levels (TBiL—OR = 0.884, 95% CI: 0.792-0.985; DBiL—OR = 0.621; 95% CI: 0.424-0.909) only in males but not in females. Future studies should further evaluate whether interventions that increase serum bilirubin levels will have a particular role in PAD prevention in males.

Short stature in men is associated with subclinical peripheral arterial disease

VASA ◽  
2016 ◽  
Vol 45 (6) ◽  
pp. 486-490
Author(s):  
Arto Heikkilä ◽  
Maarit Venermo ◽  
Hannu Kautiainen ◽  
Pertti Aarnio ◽  
Päivi Korhonen
Keyword(s):  
Cardiovascular Risk ◽  
Peripheral Arterial Disease ◽  
Short Stature ◽  
Smoking Status ◽  
Ankle Brachial Index ◽  
Arterial Disease ◽  
Inverse Association ◽  
Cross Sectional ◽  
Peripheral Arterial ◽  
The Relationship

Abstract. Background: Peripheral arterial disease (PAD) affects approximately 202 million individuals around the world and is associated with a high risk of myocardial infarction, stroke and death. Although there is a clear inverse association between adult height and the risk of cardiovascular disease, little is known about the relationship between height and PAD. The aim of our study was to assess the relationship between subclinical PAD and height. Patients and methods: In a cross-sectional cardiovascular risk factor study in southwestern Finland, ankle brachial index (ABI) and other risk factors were measured from a total of 972 cardiovascular risk subjects derived from the general population. None of them had previously diagnosed diabetes, cardiovascular or renal disease or intermittent claudication. Subjects with an ABI ≤ 0.90 were categorized as having subclinical PAD. Results: The average age of the study subjects was 58.1 ± 6.7 years for men and 58.8 ± 6.9 years for women. The prevalence of subclinical PAD was 5 % (95 % CI 3 % − 7 %) (23/455) among men and 5 % (95 % CI 3 %−7 %) (26/517) among women. The mean ABI among men and women was 1.09 ± 0.12 and 1.08 ± 0.12, respectively. In men, there was an inverse association between height and the prevalence of subclinical PAD (p < 0.001) along with a positive association between height and ABI values (p < 0.001). In a multivariate model, height, age and current smoking status remained independent factors that were associated with subclinical PAD in men, whereas in women, only pulse pressure was associated with subclinical PAD. Conclusions: Short stature in men is associated with subclinical PAD and lower ABI values.

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