Prevalence of developmental odontogenic cysts in children and adolescents with emphasis on dentigerous cyst and odontogenic keratocyst (keratocystic odontogenic tumor)

OBJECTIVES: The current study was conducted to analyze immunohistochemical appearance of P53 protein in odontogenic cysts. METHODOLOGY: Thirty paraffin blocks of confirmed case were prepared to investigate the immunohistochemical appearance of P53 protein. RESULTS: Sixteen out of thirty odontogenic cysts (53.3%) showed P53, four out of ten dentigerous cyst (40%) had P53, twelve out of fifteen odontogenic keratocysts (80%) expressed P53 while none of the five radicular cysts (0%) showed P53 protein. CONCLUSION: Reclassification of OKC as keratocystic odontogenic tumor was supported by the present study and its findings.

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The immunoprofile of odontogenic keratocyst (keratocystic odontogenic tumor) that includes expression of PTCH, SMO, GLI-1 and bcl-2 is similar to ameloblastoma but different from odontogenic cysts

Journal of Oral Pathology and Medicine ◽

10.1111/j.1600-0714.2009.00778.x ◽

2009 ◽

Vol 38 (7) ◽

pp. 597-604 ◽

Cited By ~ 31

Author(s):

M. Vered ◽

O. Peleg ◽

S. Taicher ◽

A. Buchner

Keyword(s):

Odontogenic Tumor ◽

Odontogenic Keratocyst ◽

Odontogenic Cysts ◽

Keratocystic Odontogenic Tumor ◽

Gli 1

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Keratocystic Odontogenic Tumor Versus Odontogenic Keratocyst–The Issue of Adequate Nomenclature

Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.joms.2010.12.021 ◽

2011 ◽

Vol 69 (5) ◽

pp. 1267-1268 ◽

Cited By ~ 3

Author(s):

Izabela Mojsa ◽

Tomasz Kaczmarzyk

Keyword(s):

Odontogenic Tumor ◽

Odontogenic Keratocyst ◽

Keratocystic Odontogenic Tumor

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Evaluation of the Connective Tissue Wall in Sporadic Cases of Keratocystic Odontogenic Tumor (KCOT) Using MMP-9 and Confocal Microscopy: A Retrospective Study

Journal of Advanced Oral Research ◽

10.1177/2320206820977676 ◽

2021 ◽

Vol 12 (1) ◽

pp. 134-143

Author(s):

Merlin Jayaraj ◽

Pratibha Ramani ◽

Herald J. Sherlin

Keyword(s):

Confocal Microscopy ◽

Connective Tissue ◽

Dentigerous Cyst ◽

Odontogenic Tumor ◽

Biological Behavior ◽

Keratocystic Odontogenic Tumor ◽

Extracellular Matrix Components ◽

Sporadic Cases ◽

Odontogenic Lesion ◽

Inherent Nature

Background: Keratocystic odontogenic tumor (KCOT) is an odontogenic lesion which manifests distinct biological behavior. Predominant studies in KCOT attribute this behavior to high epithelial proliferative capacity. Besides, a few studies facet loosely arranged collagen can contribute to the behavior of KCOT. Matrix metalloproteinases (MMP) are enzymes that degrade extracellular matrix components under both physiologic and pathologic conditions. The loosely arranged collagen in connective tissue wall of KCOT could be related to the degree of MMP-9 expression. Aim: To evaluate the arrangement of collagen fibers along with immunoexpression of MMP-9 and to relate to its neoplastic biologic behavior in sporadic cases of KCOT. Materials and Methods: KCOT ( n = 23) and dentigerous cyst (DC) ( n = 15) samples were processed for the following techniques: Masson’s trichrome stain for light microscopy, PMA-PSR stain for confocal microscopy, and MMP-9 for immunohistochemistry. Results: In Masson’s trichrome analysis, correlation of collagen fiber arrangement in the deeper regions with color intensity for KCOT was found to be statistically significant ( P = .033). In confocal microscopy, there was no difference between intensities in KCOT ( P = .990) and DC ( P = .233), respectively. The immunoexpression of MMP-9 in the connective tissue wall of DC (73.3%) was relatively higher than that of KCOT (60.8%). However, on comparison between KCOT and DC in the presence of inflammation, the immunoexpression of MMP-9 was higher in DC (100%) than KCOT (69.9%) and was statistically significant ( P = .028). Conclusion: It was concluded that the loose connective tissue wall in KCOT is because of the inherent nature of the lesion that could facilitate its biologic behavior. If inflammation is present, this could further aggravate the tumorigenic behavior.

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Keratocystic Odontogenic Tumor of the Maxilla: Report of a Rare Case and Review of Literature

World Journal of Dentistry ◽

10.5005/jp-journals-10015-1137 ◽

2012 ◽

Vol 3 (1) ◽

pp. 100-108 ◽

Cited By ~ 2

Author(s):

A Nagaraja ◽

Praveen S Anigol ◽

Venkatesh Vishwanath Kamath ◽

Krishnanand P Setlur

Keyword(s):

Rare Case ◽

Third Molar ◽

Odontogenic Tumor ◽

Odontogenic Keratocyst ◽

Keratocystic Odontogenic Tumor ◽

Review Of Literature ◽

Middle Aged ◽

Maxillary Third Molar ◽

Aged Individual ◽

Extensive Involvement

ABSTRACT The odontogenic keratocyst (OKC) has recently been reclassified by the WHO (2005), as keratocystic odontogenic tumor (KCOT) based on clinical, histological and immunohistochemical parameters. KCOT more commonly occurs in the mandible and cases involving the maxilla are infrequent. We report an unusual and rare case of a KCOT of the maxilla in a middle-aged individual with extensive involvement and displacement of the maxillary third molar to the zygomatic region. A discussion of the parameters involved in the reclassification of the lesion as a tumor is presented alongwith a review of literature. How to cite this article Nagraja A, Anigol PS, Kamath VV, Setlur KP. Keratocystic Odontogenic Tumor of the Maxilla: Report of a Rare Case and Review of Literature. World J Dent 2012;3(1):100-108.

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Keratocystic Odontogenic Tumor (Odontogenic Keratocyst): Preliminary Retrospective Review of Epidemiologic, Clinical, and Radiologic Features of 261 Lesions From University of Turin

Journal of Oral and Maxillofacial Surgery ◽

10.1016/j.joms.2010.05.068 ◽

2010 ◽

Vol 68 (12) ◽

pp. 2994-2999 ◽

Cited By ~ 45

Author(s):

Paolo Boffano ◽

Emanuele Ruga ◽

Cesare Gallesio

Keyword(s):

Retrospective Review ◽

Odontogenic Tumor ◽

Odontogenic Keratocyst ◽

Keratocystic Odontogenic Tumor ◽

Radiologic Features

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A Clinicopathological Report of Four Cases of Squamous Odontogenic Tumor-Like Proliferations in Odontogenic Cysts: Suggested Opinions regarding This Unusual Nature

Case Reports in Dentistry ◽

10.1155/2020/6978587 ◽

2020 ◽

Vol 2020 ◽

pp. 1-4

Author(s):

Massoumeh Zargaran ◽

Setareh Shojaei

Keyword(s):

Squamous Cell Carcinoma ◽

Cell Carcinoma ◽

Dentigerous Cyst ◽

Odontogenic Tumor ◽

Odontogenic Cysts ◽

Epithelial Lining ◽

Epithelial Cyst ◽

Effective Role ◽

Well Differentiated ◽

Cyst Lining

Distinguishing squamous odontogenic tumor-like proliferations (SOTLPs) is important in odontogenic cysts to avoid misinterpretation such as a squamous odontogenic tumor, well-differentiated squamous cell carcinoma, and acanthomatous type of ameloblastoma. This study is aimed at reporting 4 cases of these clinicopathological proliferations in order to shed more light on the importance of distinguishing them from other similar types. 150 odontogenic cysts were studied in which four cases (2.66%) with SOTLPs were identified including 2 radicular cysts, 1 dentigerous cyst, and 1 odontogenic keratocyst. These proliferations were observed in the cysts’ wall particularly adjacent to the epithelial lining. All cysts had inflammation while 3 cases showed budding from the epithelial cyst lining. The findings suggested that lining of odontogenic cysts could be a source of SOTLPs, and inflammation probably played an effective role in their development. Its incidence was 2.66% in the present study. Although SOTLPs are not frequent in odontogenic cysts, their identification is important to prevent wrong histopathologic interpretation and treatment.

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The Possible Role of Mast Cells in the Odontogenic Cyst’s Pathogenesis: A Comparative Study between Dentigerous Cyst and Keratocystic Odontogenic Tumor

Pathology Research International ◽

10.1155/2016/8754567 ◽

2016 ◽

Vol 2016 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Sareh Farhadi ◽

Fatemeh Shahsavari ◽

MirMahdi Davardan

Keyword(s):

Mast Cell ◽

Mast Cells ◽

Dentigerous Cyst ◽

Test Method ◽

Odontogenic Tumor ◽

Blue Staining ◽

Keratocystic Odontogenic Tumor ◽

Wide Range ◽

Significant Difference ◽

Cell Densities

Background. Recently, mast cells were recognized in the pathogenesis of more aggressive pathologic lesions. This study was aimed to evaluate and compare the density of mast cells in Dentigerous cyst (DC) and Keratocystic odontogenic tumor (KCOT) regarding their different clinical behavior. Method. This study was conducted on 23 and 26 cases of DC and KCOT, respectively. Four-micron sections were prepared for Toluidine blue staining and mast cell densities in two desired cysts were studied. Final data was analyzed via t-test and Mann-Whitney U test method regarding the significant level lower than 0.05. Results. Mast cell densities were significantly higher in KCOTs for deep and superficial layers and both layers (P<0.05). The density of degranulated mast cells in the deeper layers and both layers was significantly higher in KCOTs (P<0.05). However, the density of degranulated mast cells in the superficial layer had no significant difference (P>0.05). Conclusion. It seems that mast cells may be involved in the pathogenesis of KCOT, but, regarding wide range of mast cell’s biologic activities, further investigations are recommended to confirm the issue and prepare the details.

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