The Role of High-Frequency Audiometry in Early Detection of Ototoxicity

1985 ◽  
Vol 24 (6) ◽  
pp. 387-395 ◽  
Author(s):  
W. A. Dreschler ◽  
R.J.A.M. v.d. Hulst ◽  
R. A. Tange ◽  
N. A. M. Urbanus
Keyword(s):  
Early Detection ◽  
High Frequency ◽  
High Frequency Audiometry

High Frequency Audiometry in Prospective Clinical Research of Ototoxicity Due to Platinum Derivatives

1988 ◽  
Vol 97 (2) ◽  
pp. 133-137 ◽  
Author(s):  
R. J. A. M. van der Hulst ◽  
W. A. Dreschler ◽  
N. A. M. Urbanus
Keyword(s):  
Hearing Loss ◽  
Side Effects ◽  
Early Detection ◽  
High Frequency ◽  
Clinical Use ◽  
Treatment Groups ◽  
High Frequency Audiometry ◽  
First Results ◽  
Hearing Damage

The results of clinical use of routine high frequency audiometry in monitoring the ototoxic side effects of platinum and its derivatives are described in this prospective study. After demonstrating the reproducibility of the technique, we discuss the first results of an analysis of ototoxic side effects in 75 patients (150 ears). Significant differences in the pattern of hearing loss were registered for the different platinum treatment groups (cisplatin 20 mg/m2, cisplatin 50 mg/m2, and carboplatin 350 mg/m2). In the groups receiving cisplatin 50 mg/m2 and carboplatin 350 mg/m2, 42% and 25%, respectively, of the investigated ears proved to be undamaged, versus 9% undamaged in the group receiving cisplatin 20 mg/m2 (p< .01). Ototoxic hearing loss started mainly (46% to 70%) in the higher frequencies (10,000 to 18,000 Hz) and developed into a broader-range hearing loss (1,000 to 18,000 Hz) during treatment in 13% to 43% (p< .01). The onset of hearing damage was influenced by the patient's age (p< .001) and the existence of a troubled otologic history (p< .05). The study demonstrates the important role of high frequency audiometry in early detection and monitoring of ototoxic damage.

Role of High-Frequency Audiometry in the Early Detection of Ototoxicity: II. Clinical Aspects

1989 ◽  
Vol 28 (4) ◽  
pp. 211-220 ◽  
Author(s):  
W. A. Dreschler ◽  
R.J.A.M. v.d. Hulst ◽  
R. A. Tange ◽  
N. A. M. Urbanus
Keyword(s):  
Early Detection ◽  
High Frequency ◽  
Clinical Aspects ◽  
High Frequency Audiometry

Extended high-frequency audiometry as early detection of hearing loss in primary Sjögren syndrome

2017 ◽  
Vol 36 (10) ◽  
pp. 2237-2241 ◽  
Author(s):  
José Luis Treviño González ◽  
Janett Riega Torres ◽  
Yolisa Hinojosa Ríos ◽  
Mario Jesús Villegas González ◽  
Marco A. Mendez Saenz ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Early Detection ◽  
High Frequency ◽  
Sjögren Syndrome ◽  
Sjogren Syndrome ◽  
Primary Sjögren Syndrome ◽  
High Frequency Audiometry

scholarly journals Ototoxicity and the role of high‐frequency audiometry

1984 ◽  
Vol 76 (S1) ◽  
pp. S74-S74 ◽  
Author(s):  
W. A. Dreschler ◽  
R.J.A.M. v.d. Hulst ◽  
R. A. Tange
Keyword(s):  
High Frequency ◽  
High Frequency Audiometry

Neomycin Ototoxicity

1978 ◽  
Vol 87 (2) ◽  
pp. 211-215 ◽  
Author(s):  
K. M. Ward ◽  
F. J. Rounthwaite
Keyword(s):  
Early Detection ◽  
Inner Ear ◽  
High Frequency ◽  
English Literature ◽  
Biochemical Basis ◽  
High Frequency Audiometry ◽  
Inner Ear Fluids

A case of oral neomycin ototoxicity is presented, followed by a summary of known cases in the English literature. While it is known that neomycin is concentrated in the inner ear fluids, at the present time the biochemical basis of its ototoxic effect has not been definitively elucidated. High frequency audiometry can aid in the early detection of the onset of neomycin-induced deafness. Dialysis has a limited but useful role in preventing neomycin ototoxicity.

scholarly journals Early detection of ototoxicity by high-frequency audiometry: A case study

1987 ◽  
Vol 34 (1) ◽  
Author(s):  
Gustav R. Voogt
Keyword(s):  
Early Detection ◽  
Inner Ear ◽  
High Frequency ◽  
Aminoglycoside Antibiotic ◽  
Black Female ◽  
Cardiac Patient ◽  
High Frequency Audiometry ◽  
Hearing Acuity ◽  
New Type

The effect of an ototoxic aminoglycoside antibiotic (tobramycin) on the hearing acuity of an adult Black female cardiac patient was evaluated with a new type of high-frequency audiometer. Results indicated the effectivity of this audiometer for the early detection of ototoxicity. The possibility of higher susceptibility ototoxic damage in Blacks due to a higher concentration of melanin in the inner ear is discussed.

Role of Extended High-Frequency Audiometry in the Early Diagnosis of Occupational Hearing Loss

Skull Base ◽  
2009 ◽  
Vol 19 (S 02) ◽  
Author(s):  
M. Riga ◽  
G. Korres ◽  
D.G. Balatsouras ◽  
M. Tzagaroulakis ◽  
S. Korres
Keyword(s):  
Hearing Loss ◽  
Early Diagnosis ◽  
High Frequency ◽  
High Frequency Audiometry ◽  
Occupational Hearing Loss

scholarly journals High-Frequency Audiometry for Early Detection of Hearing Loss: A Narrative Review

2021 ◽  
Vol 18 (9) ◽  
pp. 4702
Author(s):  
Michaela Škerková ◽  
Martina Kovalová ◽  
Eva Mrázková
Keyword(s):  
Hearing Loss ◽  
Early Detection ◽  
High Frequency ◽  
Age Groups ◽  
Hearing Threshold ◽  
Control Group ◽  
The People ◽  
High Frequency Audiometry ◽  
Scientific Papers ◽  
Workplace Noise

The WHO considers hearing loss to be a major global problem. A literature search was conducted to see whether high-frequency audiometry (HFA) could be used for the early detection of hearing loss. A further aim was to see whether any differences exist in the hearing threshold using conventional audiometry (CA) and HFA in workers of different age groups exposed to workplace noise. Our search of electronic databases yielded a total of 5938 scientific papers. The inclusion criteria were the keywords “high frequency” and “audiometry” appearing anywhere in the article and the participation of unexposed people or a group exposed to workplace noise. Fifteen studies met these conditions; the sample size varied (51–645 people), and the age range of the people studied was 5–90 years. Commercial high-frequency audiometers and high-frequency headphones were used. In populations unexposed to workplace noise, significantly higher thresholds of 14–16 kHz were found. In populations with exposure to workplace noise, significantly higher statistical thresholds were found for the exposed group (EG) compared with the control group (CG) at frequencies of 9–18 kHz, especially at 16 kHz. The studies also showed higher hearing thresholds of 10–16 kHz in respondents aged under 31 years following the use of personal listening devices (PLDs) for longer than 5 years. The effect of noise-induced hearing loss (NIHL) first became apparent for HFA rather than CA. However, normative data have not yet been collected. Therefore, it is necessary to establish a uniform evaluation protocol accounting for age, sex, comorbidities and exposures, as well as for younger respondents using PLDs.

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