A Nomographic Solution for Lung Volume Determinations in the closed System Helium Dilution Method

1956 ◽  
Vol 8 (4) ◽  
pp. 329-332 ◽  
Author(s):  
G. Birath ◽  
E. W. Swenson
Keyword(s):  
Lung Volume ◽  
Closed System ◽  
Dilution Method ◽  
Helium Dilution

scholarly journals Measurement of the Total Lung Volume Using an Adjusted Single-Breath Helium Dilution Method in Patients With Obstructive Lung Disease

2021 ◽  
Vol 8 ◽  
Author(s):  
Qing Liu ◽  
Lingxiao Zhou ◽  
Peiling Feng ◽  
Jinkai Liu ◽  
Bin Shen ◽  
...  
Keyword(s):  
Lung Disease ◽  
Lung Volume ◽  
Obstructive Lung Disease ◽  
Validation Cohort ◽  
Training Group ◽  
Whole Body ◽  
Dilution Method ◽  
Total Lung Volume ◽  
Single Breath ◽  
Helium Dilution

Background: Whole-body plethysmography (WBP) is the gold standard for measuring lung volume, but its clinical application is limited as it requires expensive equipment and is not simple to use. Studies have shown that the single-breath helium dilution (SBHD) method, which is commonly used in clinical practice, significantly underestimates lung volume in patients with obstructive lung disease (OLD). By comparing the differences in lung volume measured using SBHD and WBP, we aimed to establish a correction equation for the SBHD method to determine the total lung volume in patients with OLD of different severities.Methods: From 628 patients with OLD simultaneously subjected to SBHD and WBP, 407 patients enrolled between January 2018 and November 2019 were in the training group and 221 enrolled between December 2019 and December 2020 were in the prospective verification cohort. The multiple linear regression equation was used for data in the training group to establish a correction equation for SBHD to determine the total lung volume, and this was validated in the prospective validation cohort.Results: There was a moderate positive correlation between total lung capacity (TLC) determined using the SBHD [TLC (SBHD)] and WBP methods [TLC (WBP)] (r = 0.701; P < 0.05), and the differences between TLC (SBHD) and TLC (WBP) (ΔTLC) were related to the severity of obstruction. As the severity of obstruction increased, the TLC was underestimated by the SBHD method. We established the following correction equation: TLC (adjusted SBHD) (L) = −0.669 + 0.756*TLC(SBHD)(L) – 0.047*FEV1FVC+0.039*height (cm)–0.009*weight(kg)(r2 = 0.753 and adjusted r2 = 0.751). Next, we validated this equation in the validation cohort. With the correction equation, no statistical difference was observed between TLC (adjusted SBHD) and TLC (WBP) among the obstruction degree groups (P > 0.05).Conclusions: The SBHD method is correlated with WBP to measure the total lung volume, but the SBHD method presents limitations in determining the total lung volume in patients with obstructive lung disease. Here, we established an effective and reliable correction equation in order to accurately assess the total lung volume of patients with OLD using the SBHD method.

Speech Breathing in Children and Adolescents

1990 ◽  
Vol 33 (1) ◽  
pp. 51-69 ◽  
Author(s):  
Jeannette D. Hoit ◽  
Thomas J. Hixon ◽  
Peter J. Watson ◽  
Wayne J. Morgan
Keyword(s):  
Children And Adolescents ◽  
Lung Volume ◽  
Age Groups ◽  
Important Variable ◽  
Clinical Implications ◽  
Tidal Breathing ◽  
Breathing Apparatus ◽  
Age Related ◽  
Speech Breathing ◽  
Helium Dilution

An investigation was conducted to elucidate the nature of speech breathing in children and adolescents and to determine if sex and age influence performance. Eighty healthy boys and girls representing four age groups (7, 10, 13, and 16 years) were studied using helium dilution to obtain measures of subdivisions of the lung volume and using magnetometers to obtain measures of resting tidal breathing and speech breathing. Results for subdivisions of the lung volume and resting tidal breathing revealed sex- and age-related differences, most of which were attributable to differences in breathing apparatus size. Results for speech breathing indicated that sex was not an important variable, but that age was critical in determining speech breathing performance. The most substantial differences were between the 7-year-old group and older groups. These differences were characterized by larger lung volume, rib cage volume, and abdominal volume initiations and terminations for breath groups, larger lung volume excursions per breath group, fewer numbers of syllables per breath group, and larger lung volume expenditures per syllable for the 7-year-old group compared to older groups. In most respects, speech breathing appeared adultlike by the end of the first decade of life. Clinical implications regarding these findings are offered.

Hydrostatic weighing at residual volume and functional residual capacity

1980 ◽  
Vol 49 (1) ◽  
pp. 157-159 ◽  
Author(s):  
T. R. Thomas ◽  
G. L. Etheridge
Keyword(s):  
Prone Position ◽  
Functional Residual Capacity ◽  
Lung Volume ◽  
Residual Volume ◽  
Body Density ◽  
Residual Capacity ◽  
Hydrostatic Weighing ◽  
Helium Dilution ◽  
The Subject ◽  
The Difference

Hydrostatic weighing (HW) was performed at both residual volume (RV) and functional residual capacity (FRC) to determine if underwater weighing at different lung volumes affected the measurement of body density. Subjects were 43 males, 18-25 yr. Subjects were submerged in the prone position, and the lung volume was measured by helium dilution at the time of the underwater weighing. Underwater weight was first assessed at FRC followed by assessment at RV. Changes in lung volume were accurately reflected in the underwater weight. Body density (D) was not different with the use of the FRC (mean D = 1.0778) or RV (mean D = 1.0781) data. Percent fat values for the FRC and RV data were 9.3 ± 5.4 and 9.2 ± 5.1%, respectively, and were not statistically different. The results indicate that the difference between percent fat determinations by HW in the prone position at FRC and RV is negligible. Because measurement of underwater weight at FRC is more comfortable for the subject, this may be the method of choice when the lung volume can be measured during the underwater weighing.

scholarly journals Correction: Nitrogen washout/washin, helium dilution and computed tomography in the assessment of end expiratory lung volume

Critical Care ◽  
2009 ◽  
Vol 13 (2) ◽  
pp. 405 ◽  
Author(s):  
Davide Chiumello ◽  
Massimo Cressoni ◽  
Monica Chierichetti ◽  
Federica Tallarini ◽  
Marco Botticelli ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lung Volume ◽  
Nitrogen Washout ◽  
Helium Dilution

scholarly journals Nitrogen washout/washin, helium dilution and computed tomography in the assessment of end expiratory lung volume

Critical Care ◽  
2008 ◽  
Vol 12 (6) ◽  
pp. R150 ◽  
Author(s):  
Davide Chiumello ◽  
Massimo Cressoni ◽  
Monica Chierichetti ◽  
Federica Tallarini ◽  
Marco Botticelli ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lung Volume ◽  
Nitrogen Washout ◽  
Helium Dilution

Measurement of lung diffusing capacity by means of C14O in a closed system

1964 ◽  
Vol 19 (1) ◽  
pp. 59-74 ◽  
Author(s):  
Paul S⊘lvsteen
Keyword(s):  
Carbon Monoxide ◽  
Uniform Distribution ◽  
Lung Volume ◽  
Closed System ◽  
Normal Subjects ◽  
Alveolar Ventilation ◽  
Diffusing Capacity ◽  
Mathematical Equations ◽  
Experimental Findings ◽  
Better Than

A method of measuring the lung diffusing capacity (Dl) with radioactive carbon monoxide (C14O) and nonuniformity of ventilation with nonabsorbable gas in a closed system is described. Treating ventilation as a continuous phenomenon and disregarding dead space, the mathematical equations for uniform and nonuniform ventilation (two lung regions ventilated in parallel) are derived. It is proved that sooner or later the curve for carbon monoxide, plotted on semilogarithmic paper, will be rectilinear. Experiments in six normal subjects and eight patients with chronic lung disease are described. Determinations of the distribution of the ventilation and the Dl are made in separate experiments. Since the method is unreliable at high Dl values, many of the Dl estimations are performed at high oxygen tension, which reduces the apparent Dl. It is shown that the assumption of a uniform distribution of Dl to lung volume explains the experimental findings better than the assumption of a uniform distribution of Dl to alveolar ventilation. Dl was decreased in four of the eight patients. mathematics of uniform and nonuniform ventilation; distribution of lung diffusing capacity in relation to lung volume and alveolar ventilation; N2 curve for use in calculating alveolar ventilation and regional lung volumes; CO curve for use in calculating lung diffusing capacity; diffusing capacity of lung determined with a closed system Submitted on October 15, 1962

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