The kinetics of myoglobin in old volunteers and in patients with acute myocardial infarction

1978 ◽  
Vol 38 (6) ◽  
pp. 561-565 ◽  
Author(s):  
Christer Sylvén
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Kinetics Of

scholarly journals Plasma kinetics of mature PCSK9, furin-cleaved PCSK9, and Lp(a) with or without administration of PCSK9 inhibitors in acute myocardial infarction

2020 ◽  
Vol 76 (4) ◽  
pp. 395-401 ◽  
Author(s):  
Akihiro Nakamura ◽  
Masanori Kanazawa ◽  
Yuta Kagaya ◽  
Masateru Kondo ◽  
Kenjiro Sato ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Pcsk9 Inhibitors ◽  
Plasma Kinetics ◽  
Kinetics Of

scholarly journals RELEASE KINETICS OF GALECTIN-3, GDF-15 AND NT-PROBNP IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

2014 ◽  
Vol 63 (12) ◽  
pp. A255
Author(s):  
Christoph Liebetrau ◽  
Luise Gaede ◽  
Oliver Dörr ◽  
Sebastian Wolter ◽  
Christian Troidl ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Release Kinetics ◽  
Galectin 3 ◽  
Kinetics Of

Kinetics of high-sensitivity cardiac troponin T or troponin I compared to creatine kinase in patients with revascularized acute myocardial infarction

2015 ◽  
Vol 53 (5) ◽  
Author(s):  
Kamila Solecki ◽  
Anne Marie Dupuy ◽  
Nils Kuster ◽  
Florence Leclercq ◽  
Richard Gervasoni ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Cardiac Troponin ◽  
Troponin I ◽  
Troponin T ◽  
High Sensitivity ◽  
Cardiac Troponin T ◽  
Significant Difference ◽  
Kinetics Of

AbstractCardiac biomarkers are the cornerstone of the biological definition of acute myocardial infarction (AMI). The key role of troponins in diagnosis of AMI is well established. Moreover, kinetics of troponin I (cTnI) and creatine kinase (CK) after AMI are correlated to the prognosis. New technical assessment like high-sensitivity cardiac troponin T (hs-cTnT) raises concerns because of its unclear kinetic following the peak. This study aims to compare kinetics of cTnI and hs-cTnT to CK in patients with large AMI successfully treated by percutaneous coronary intervention (PCI).We prospectively studied 62 patients with anterior AMI successfully reperfused with primary angioplasty. We evaluated two consecutive groups: the first one regularly assessed by both CK and cTnI methods and the second group by CK and hs-cTnT. Modeling of kinetics was realized using mixed effects with cubic splines.Kinetics of markers showed a peak at 7.9 h for CK, at 10.9 h (6.9–12.75) for cTnI and at 12 h for hs-cTnT. This peak was followed by a nearly log linear decrease for cTnI and CK by contrast to hs-cTnT which appeared with a biphasic shape curve marked by a second peak at 82 h. There was no significant difference between the decrease of cTnI and CK (p=0.63). CK fell by 79.5% (76.1–99.9) vs. cTnI by 86.8% (76.6–92.7). In the hs-cTnT group there was a significant difference in the decrease by 26.5% (9–42.9) when compared with CK that fell by 79.5% (64.3–90.7).Kinetic of hs-cTnT and not cTnI differs from CK. The role of hs-cTnT in prognosis has to be investigated.

Release kinetics of early ischaemic biomarkers in a clinical model of acute myocardial infarction

Heart ◽  
2014 ◽  
Vol 100 (8) ◽  
pp. 652-657 ◽  
Author(s):  
Christoph Liebetrau ◽  
Holger M Nef ◽  
Oliver Dörr ◽  
Luise Gaede ◽  
Jedrzej Hoffmann ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Release Kinetics ◽  
Hypertrophic Obstructive Cardiomyopathy ◽  
Fatty Acid Binding ◽  
Continuous Increase ◽  
Clinical Model ◽  
Additional Information ◽  
Coronary Syndrome ◽  
Kinetics Of

ObjectiveTo determine the release kinetics of different biomarkers with potential as novel early ischaemic biomarkers in patients with acute coronary syndrome (ACS); it is difficult to establish the detailed release kinetics in patients with acute myocardial infarction (AMI).MethodsWe analysed the release kinetics of soluble fms-like tyrosine kinase (sFlt-1), ischaemia modified albumin (IMA), and heart-type fatty acid binding protein (hFABP) in patients with hypertrophic obstructive cardiomyopathy who were undergoing transcoronary ablation of septal hypertrophy (TASH), a procedure mimicking AMI. Consecutive patients (n=21) undergoing TASH were included. Blood samples were collected before TASH and 15, 30, 45, 60, 75, 90, and 105 min and 2, 4, 8, and 24 h after TASH. sFlt-1 and hFABP were quantified in serum, and IMA was quantified in plasma using immunoassays.ResultssFLT-1 and hFABP increased significantly 15 min after induction of AMI vs baseline as follows: sFlt-1, 3657.5 ng/L (IQR 2302.3–4475.0) vs 76.0 ng/L (IQR 71.2–88.8) (p<0.001); hFABP, 9.0 ng/mL (IQR 7.0–15.4) vs 4.6 ng/mL (IQR 3.4–7.1) (p<0.001). sFlt-1 demonstrated a continuous decrease after the 15th min. hFABP showed a continuous increase until the 8th hour with a decline afterwards. The IMA concentrations increased significantly 30 min after induction of AMI vs baseline, with values of 26.0 U/mL (IQR 21.8–38.6) vs 15.6 U/mL (IQR 10.1–24.7) (p=0.02), and then decreased after 75 min.ConclusionssFlt-1 and hFABP increased very early after induction of myocardial ischaemia, showing different release kinetics. The additional information provided by these findings is helpful for developing their potential combined use with cardiac troponins in patients with suspected AMI.

Absorption Kinetics of Low Dose Aspirin in Patients with Evolving Acute Myocardial Infarction

1994 ◽  
Vol 7 (4) ◽  
pp. 169-174 ◽  
Author(s):  
C. L. Zhang ◽  
K. M. Wilson ◽  
I. Stafford ◽  
F. Bochner ◽  
J. D. Horowitz
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Low Dose ◽  
Absorption Kinetics ◽  
Dose Aspirin ◽  
Low Dose Aspirin ◽  
Kinetics Of

scholarly journals Kinetics of plasma von Willebrand factor in acute myocardial infarction patients: a meta-analysis

Oncotarget ◽  
2017 ◽  
Vol 8 (52) ◽  
pp. 90371-90379 ◽  
Author(s):  
Xia Wang ◽  
Junyu Zhao ◽  
Yong Zhang ◽  
Xiujuan Xue ◽  
Jie Yin ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Von Willebrand Factor ◽  
Meta Analysis ◽  
Von Willebrand ◽  
Willebrand Factor ◽  
Kinetics Of

scholarly journals Reference Values and Release Kinetics of B-Type Natriuretic Peptide Signal Peptide in Patients with Acute Myocardial Infarction

2015 ◽  
Vol 61 (12) ◽  
pp. 1532-1539 ◽  
Author(s):  
Christoph Liebetrau ◽  
Luise Gaede ◽  
Oliver Dörr ◽  
Johannes Blumenstein ◽  
Stefanie Rosenburg ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Natriuretic Peptide ◽  
Signal Peptide ◽  
Troponin T ◽  
Reference Group ◽  
Release Kinetics ◽  
Structural Heart Disease ◽  
Time Points ◽  
Kinetics Of

Abstract BACKGROUND The signal peptide for human B-type natriuretic peptide preprohormone (BNPsp), which is released from cardiomyocytes, is increased in plasma of patients with acute myocardial infarction (AMI); however, its exact release kinetics have not been defined. METHODS We measured BNPsp and high-sensitivity cardiac troponin T (hs-cTnT) in a reference group of individuals without structural heart disease (n = 285) and determined the release kinetics of these biomarkers in patients (n = 29) with hypertrophic obstructive cardiomyopathy undergoing transcoronary ablation of septal hypertrophy (TASH), a procedure allowing exact timing of onset of iatrogenic AMI. Blood samples were collected before TASH and at numerous preselected time points after TASH. RESULTS The reference median BNPsp concentration was 53.4 pmol/L [interquartile range (IQR) 47.0–61.0; 95th percentile 85.9 pmol/L; 99th percentile 116.3 pmol/L]. Baseline concentrations in patients undergoing TASH were higher than in the reference group [91.9 pmol/L (IQR 62.9–116.4); P &lt; 0.0001]. BNPsp increased significantly, peaking at 15 min after induction of AMI [149.6 pmol/L (109.5–204.9) vs baseline; P = 0.004] and declining slowly thereafter, falling below the preprocedural value after 8 h (P = 0.014). hs-cTnT increased significantly 15 min after induction of AMI [26 ng/L (19–39) vs 18 ng/L (11–29); P = 0.001] and remained high at all later time points. CONCLUSIONS BNPsp concentrations increased immediately after AMI induction, providing early evidence of myocardial injury. The release kinetics of BNPsp differed from those of hs-cTnT. These findings provide information that should help in establishing the diagnostic value of BNPsp in the setting of early AMI.

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