An Epidemic Outbreak of Group B Meningococcal Disease on the Faroe Islands

1988 ◽  
Vol 20 (3) ◽  
pp. 291-296 ◽  
Author(s):  
Pál Weihe ◽  
Bjørn Mathiassen ◽  
Jens Møller Rasmussen ◽  
Turid Petersen ◽  
Henrik Isager
1991 ◽  
Vol 106 (3) ◽  
pp. 445-457 ◽  
Author(s):  
S. F. Olsen ◽  
B. Djurhuus ◽  
K. Rasmussen ◽  
H. D. Joensen ◽  
S. O. Larsen ◽  
...  

SUMMARYIn a household survey in the Faroe Islands, an isolated community with hyperendemic occurrence of meningococcal disease due to serogroup B 15, 1604 persons were examined for pharyngeal carriage of Neisseria meningitidis and N. lactamica. Two areas were chosen having experienced high (HIA), and two having experienced low incidences (LIA) of disease. Living in HIA compared with LIA was associated with higher risk of N. meningitidis B 15 carriage and lower risk of N. lactamica carriage, with odds ratios of 2·7 (95% confidence interval (CI) 1·4–5·1, P = 0·003) and 0·41 (95% CI 0·31–0·53, P < 0·0001), respectively. In HIA the risk of N. meningitidis carriage was much lower in non-carriers than carriers of N. lactamica, with an odds ratio of 0·19 (95% CI 0·08–0·47, P = 0·0003); in LIA this association (odds ratio 0·51, P = 0·05) was much weaker. Children 0–14 years had substantially higher risk of being carriers of N. meningitidis group B 15 if the mothers were so, with an odds ratio of 11 (95% CI 4–29, P < 0·0001).


2007 ◽  
Vol 45 (10) ◽  
pp. 1327-1334 ◽  
Author(s):  
M. Howitz ◽  
T. G. Krause ◽  
J. B. Simonsen ◽  
S. Hoffmann ◽  
M. Frisch ◽  
...  

2019 ◽  
Vol 29 (Supplement_4) ◽  
Author(s):  
M Edelstein

Abstract Since the introduction of the expanded programme on immunization in the 1970s, vaccination has evolved from being an intervention of early infancy to being a programme targeting individuals at all stages of life including birth, infancy, childhood, teenage years, pregnancy and adulthood. The UK has been at the forefront of this lifelong approach to vaccination and has introduced vaccines at all stages of life in its national schedule, including vaccination against hepatitis B at birth, Meningococcal disease group B in infancy, influenza in primary school years, Meningococcal disease groups A, C, W and Y in teenage years, pertussis in pregnancy and shingles in older adults. Based on a range of studies conducted by Public Health England, This session will reflect on some of the challenges brought on by the life course approach in the UK including issues of access in different age groups, choosing the right age and settings for vaccinations, age-specific attitudes to vaccination and subsequent communication strategies, and challenges with monitoring a life-course programme.


2019 ◽  
Vol Volume 12 ◽  
pp. 3169-3188 ◽  
Author(s):  
Irene Rivero-Calle ◽  
Peter Francis Raguindin ◽  
Jose Gómez-Rial ◽  
Carmen Rodriguez-Tenreiro ◽  
Federico Martinón-Torres

2008 ◽  
Vol 137 (2) ◽  
pp. 161-165 ◽  
Author(s):  
M. J. SIMÕES ◽  
M. CUNHA ◽  
F. ALMEIDA ◽  
C. FURTADO ◽  
L. BRUM

SUMMARYNeisseria meningitidiscapsular switching has been reported in several countries. In order to establish the genetic relationship within group B and C strains expressing subtypes 2a or 2b, and to evaluate whether C to B capsular switching occurred in Portugal, 64 meningococci (56 serogroup C and 8 serogroup B) isolated from invasive meningococcal disease were typed using molecular methods. The studied phenotypes, 2b:P1.5,2 and 2a:P1.5-1,10-8, were the most frequent among serogroup C, but were uncommon among serogroup B strains. The multi-locus sequence typing (MLST) allelic profile and the pulsed-field gel electrophoresis (PFGE) fingerprints showed that seven serogroup B strains were genotypically identical to C strains, suggesting that capsular switching occurred. Active laboratory surveillance to find evidence of capsule switching is a now priority as MenC was introduced in the Portuguese vaccination schedule in January 2006.


Vaccine ◽  
2018 ◽  
Vol 36 (36) ◽  
pp. 5470-5476 ◽  
Author(s):  
A.L. Wilkins ◽  
M.D. Snape

2005 ◽  
Vol 16 (3) ◽  
pp. 171-174 ◽  
Author(s):  
Raymond SW Tsang ◽  
Dennis KS Law ◽  
Shaun D Tyler ◽  
Gwen S Stephens ◽  
Mark Bigham ◽  
...  

Three group BNeisseria meningitidisisolates, recovered from meningococcal disease cases in Canada and typed as B:2c:P1.5, were characterized. Multilocus sequence typing showed that all three isolates were related because of an identical sequence type (ST) 573. Isolates typed as 2c:P1.5 are common in serogroup Y meningococci but rare in isolates from serogroups B or C. Although no serogroup Y isolates have been typed as ST-573, eight isolates showed five to six housekeeping gene alleles that were identical to that of ST-573. This suggested that the B:2c:P1.5 isolates may have originated from serogroup Y organisms, possibly by capsule switching.


2004 ◽  
Vol 23 (12) ◽  
pp. S293-S298
Author(s):  
Jane O'Hallahan ◽  
Diana Lennon ◽  
Philipp Oster

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