Doppler assessed uteroplacental blood flow impedance in the first trimester: Physiological variation with site of measurement

1989 ◽  
Vol 9 (3) ◽  
pp. 177-179 ◽  
Author(s):  
Isabel Stabile ◽  
S. Campbell ◽  
J. G. Grudzinskas
Keyword(s):  
Blood Flow ◽  
First Trimester ◽  
Physiological Variation ◽  
Uteroplacental Blood Flow ◽  
Flow Impedance

scholarly journals Suppression of trophoblast uterine spiral artery remodeling by estrogen during baboon pregnancy: impact on uterine and fetal blood flow dynamics

2012 ◽  
Vol 302 (10) ◽  
pp. H1936-H1944 ◽  
Author(s):  
Graham W. Aberdeen ◽  
Thomas W. Bonagura ◽  
Chris R. Harman ◽  
Gerald J. Pepe ◽  
Eugene D. Albrecht
Keyword(s):  
Blood Flow ◽  
Uterine Artery ◽  
Umbilical Artery ◽  
First Trimester ◽  
Flow Dynamics ◽  
Spiral Artery ◽  
Uteroplacental Blood Flow ◽  
Blood Flow Dynamics ◽  
Artery Remodeling ◽  
The Impact

The present study was conducted to determine the impact of suppressing trophoblast remodeling of the uterine spiral arteries by prematurely elevating estrogen levels in the first trimester of baboon pregnancy on uterine and umbilical blood flow dynamics. Uteroplacental blood flow was assessed by Doppler ultrasonography after acute administration of saline (basal state) and serotonin on days 60, 100, and 160 of gestation (term: 184 days) to baboons in which uterine spiral artery remodeling had been suppressed by the administration of estradiol on days 25–59 of gestation. Maternal blood pressure in the basal state was increased ( P < 0.01), and uterine artery diastolic notching and the umbilical artery pulsatility index and systolic-to-diastolic ratio, reflecting downstream flow impedance, were increased ( P < 0.01) after serotonin administration on day 160, but not earlier, in baboons treated with estradiol in early gestation. These changes in uteroplacental flow dynamics in serotonin-infused, estradiol-treated animals were accompanied by a decrease ( P < 0.05) in uterine and umbilical artery volume flow and fetal bradycardia. The results of this study show that suppression of uterine artery remodeling by advancing the rise in estrogen from the second trimester to the first trimester disrupted uteroplacental blood flow dynamics and fetal homeostasis after vasochallenge late in primate pregnancy.

Estimation of forming uteroplacental blood flow in patients with threatened miscarriage in the presence of progesterone deficiency in the first trimester of pregnancy

2016 ◽  
Vol 6_2016 ◽  
pp. 54-60 ◽  
Author(s):  
Dobrokhotova Yu.E. Dobrokhotova ◽  
Zubarev A.R. Zubarev ◽  
Zalesskaya S.A. Zalesskaya ◽  
Zubareva E.A. Zubareva ◽  
Saprykina L.V. Saprykina ◽  
...  
Keyword(s):  
Blood Flow ◽  
First Trimester ◽  
Threatened Miscarriage ◽  
Uteroplacental Blood Flow ◽  
First Trimester Of Pregnancy

scholarly journals Doppler ultrasound in pregnancy – quality requirements of DEGUM and clinical application (part 2)

2021 ◽  
Author(s):  
Renaldo Faber ◽  
Kai-Sven Heling ◽  
Horst Steiner ◽  
Ulrich Gembruch
Keyword(s):  
Blood Flow ◽  
Middle Cerebral Artery ◽  
Cerebral Artery ◽  
Umbilical Artery ◽  
Prophylactic Treatment ◽  
Doppler Sonography ◽  
First Trimester ◽  
Ductus Venosus ◽  
Fetal Diagnosis

AbstractThis second part on Doppler sonography in prenatal medicine and obstetrics reviews its clinical applications. While this has not become the initially anticipated screening tool, it is used for the diagnosis and surveillance of a variety of fetal pathologies. For example, the sonography-based determination of uterine artery blood flow indices is an important parameter for the first trimester multimodal preeclampsia risk assessment, increasing accuracy and providing indication for the prophylactic treatment with aspirin. It also has significant implications for the diagnosis and surveillance of growth-restricted fetuses in the second and third trimesters through Doppler-sonographic analysis of umbilical artery, middle cerebral artery and ductus venosus. Here, especially the hemodynamics of the ductus venosus provides a critical criterium for birth management of severe, early-onset FGR before 34 + 0 weeks of gestation. Further, determination of maximum blood flow velocity of the middle cerebral artery is a central parameter in fetal diagnosis of anemia which has been significantly improved by this analysis. However, it is important to note that the mentioned improvements can only be achieved through highest methodological quality. Importantly, all these analyses are also applied to twins and higher order multiples. Here, for the differential diagnosis of specific complications such as TTTS, TAPS and TRAP, the application of Doppler sonography has become indispensable. To conclude, the successful application of Doppler sonography requires both exact methodology and precise pathophysiological interpretation of the data.

Ductus venosus revisited: A Doppler blood flow evaluation in the first trimester of pregnancy

1997 ◽  
Vol 23 (2) ◽  
pp. 171-176 ◽  
Author(s):  
Nuno Montenegro ◽  
Alexandra Matias ◽  
JoséCarlos Areias ◽  
Henrique Barros
Keyword(s):  
Blood Flow ◽  
First Trimester ◽  
Ductus Venosus ◽  
First Trimester Of Pregnancy ◽  
Blood Flow Evaluation

scholarly journals Maternal Uterine Vascular Remodeling During Pregnancy

Physiology ◽  
2009 ◽  
Vol 24 (1) ◽  
pp. 58-71 ◽  
Author(s):  
George Osol ◽  
Maurizio Mandala
Keyword(s):  
Extracellular Matrix ◽  
Blood Flow ◽  
Vascular Remodeling ◽  
Normal Pregnancy ◽  
Uterine Blood Flow ◽  
Growth And Remodeling ◽  
Cellular Mechanisms ◽  
Cellular Processes ◽  
Uteroplacental Blood Flow ◽  
Uterine Circulation

Sufficient uteroplacental blood flow is essential for normal pregnancy outcome and is accomplished by the coordinated growth and remodeling of the entire uterine circulation, as well as the creation of a new fetal vascular organ: the placenta. The process of remodeling involves a number of cellular processes, including hyperplasia and hypertrophy, rearrangement of existing elements, and changes in extracellular matrix. In this review, we provide information on uterine blood flow increases during pregnancy, the influence of placentation type on the distribution of uterine vascular resistance, consideration of the patterns, nature, and extent of maternal uterine vascular remodeling during pregnancy, and what is known about the underlying cellular mechanisms.

Viscosity of normal human blood under normothermic and hypothermic conditions

1964 ◽  
Vol 19 (1) ◽  
pp. 117-122 ◽  
Author(s):  
Peter W. Rand ◽  
Eleanor Lacombe ◽  
Hamilton E. Hunt ◽  
William H. Austin
Keyword(s):  
Blood Flow ◽  
Shear Rate ◽  
Heart Surgery ◽  
Blood Rheology ◽  
Normal Subjects ◽  
Future Studies ◽  
Flow Impedance ◽  
Normal Human ◽  
Technical Details ◽  
Normal Human Blood

Although blood viscosity varies in relation to shear rate, hematocrit, and temperature, equipment is now available with which it may be measured in respect to each of these variables. A simple, clinically practical technique for such measurement is presented. Blood from 60 normal subjects was adjusted to hematocrits 0, 20, 40, 60, and 80, and the viscosity-shear rate relationships measured at 37.0, 32.0, 27.0, and 22.0 C. The data obtained are presented as a reference for future studies using this method. Technical details are discussed and some deserving areas of application are considered. shear rate; cone-plate viscometer; hematocrit-viscosity relationships; blood, plasma; hematocrit; temperature; blood flow impedance; perfusion; shock; oliguria; dyspnea; coma; heart surgery; blood rheology; metabolism Submitted on May 31, 1963

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