A 26-week repeated-dose toxicity study of allisartan isoproxil in Sprague-Dawley rats

2013 ◽  
Vol 36 (4) ◽  
pp. 443-450 ◽  
Author(s):  
Yongzhen Liu ◽  
Hao Wang ◽  
Yumei Cheng ◽  
Jingjun Sun ◽  
Junwen Qiao ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Repeated Dose Toxicity

Repeated Dose Toxicity Study of a Live Attenuated Oral Cholera Vaccine in Sprague Dawley Rats

2009 ◽  
Vol 40 (7) ◽  
pp. 527-535 ◽  
Author(s):  
Sergio Sifontes-Rodríguez ◽  
Juan Francisco Infante-Bourzac ◽  
Daiyana Díaz-Rivero ◽  
Yulieé López-Feria ◽  
Merlin Pérez-Pérez ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Cholera Vaccine ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Repeated Dose Toxicity ◽  
Oral Cholera Vaccine

scholarly journals A twenty eight-day repeated dose toxicity study of black soybean extract in Sprague-Dawley rats

2010 ◽  
Vol 35 (1) ◽  
pp. 87-96 ◽  
Author(s):  
Akihiro Hagiwara ◽  
Norio Imai ◽  
Takamasa Numano ◽  
Hironao Nakashima ◽  
Seiko Tamano ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Black Soybean ◽  
Sprague Dawley Rats ◽  
Repeated Dose Toxicity ◽  
Soybean Extract

A 26-week repeated dose toxicity study of Xian-ling-gu-bao in Sprague-Dawley rats

2013 ◽  
Vol 145 (1) ◽  
pp. 85-93 ◽  
Author(s):  
Yumei Cheng ◽  
Yongzhen Liu ◽  
Hao Wang ◽  
Juan Li ◽  
Jin Ren ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Repeated Dose Toxicity

4-Week repeated dose oral toxicity study of N-ethyl-2-pyrrolidone in Sprague Dawley rats

2016 ◽  
Vol 81 ◽  
pp. 275-283 ◽  
Author(s):  
A.M. Saillenfait ◽  
F. Marquet ◽  
J.P. Sabaté ◽  
D. Ndiaye ◽  
A.M. Lambert-Xolin
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats ◽  
Dose Oral

Physicochemical analysis and repeated-dose 90-days oral toxicity study of nanocalcium carbonate in Sprague-Dawley rats

2014 ◽  
Vol 9 (5) ◽  
pp. 603-612 ◽  
Author(s):  
Jae Hyuck Sung ◽  
Soo Jin Park ◽  
Min Sook Jeong ◽  
Kyung Seuk Song ◽  
Kyu Sup Ahn ◽  
...  
Keyword(s):  
Physicochemical Analysis ◽  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats

Repeated dose dermal toxicity study of nano zinc oxide with Sprague-Dawley rats

2011 ◽  
Vol 31 (1) ◽  
pp. 26-32 ◽  
Author(s):  
P. Surekha ◽  
A. Sairam Kishore ◽  
A. Srinivas ◽  
G. Selvam ◽  
A. Goparaju ◽  
...  
Keyword(s):  
Zinc Oxide ◽  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Dermal Toxicity ◽  
Nano Zinc Oxide ◽  
Sprague Dawley Rats ◽  
Nano Zinc

scholarly journals Single- and repeated-dose 28-day oral toxicity study of MDM hydantoin in Sprague–Dawley rats

2020 ◽  
Author(s):  
Hansol Won ◽  
Jin Hee Lee ◽  
Ji-Hyun Seok ◽  
Kikyung Jung ◽  
Jun-Young Yang ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Sprague Dawley Rats

scholarly journals Safety Assessment of Zigbir®: A Polyherbal Formulation in Sprague-Dawley Rats

2012 ◽  
Vol 2012 ◽  
pp. 1-10 ◽  
Author(s):  
Joseph Joshua Allan ◽  
Ranjit Madhukar Bhide ◽  
Amit Agarwal
Keyword(s):  
Body Weight Gain ◽  
Lethal Dose ◽  
Clinical Signs ◽  
Food Supplement ◽  
Toxicity Study ◽  
Sprague Dawley ◽  
Polyherbal Formulation ◽  
Sprague Dawley Rats ◽  
Repeated Dose Toxicity ◽  
Effect Level

The safety of Zigbir®, a polyherbal formulation intended for use as food supplement, was evaluated in Sprague-Dawley rats treated orally at the dose of 2000 mg/kg in acute and at 250, 500, and 1000 mg/kg for 90 days in subchronic toxicity study. The median lethal dose of Zigbir® was found to be more than 2000 mg/kg, and fourteen-day repeated dose toxicity study revealed it to be safe up to 1000 mg/kg. The subchronic study did not show any mortality or treatment-related adverse clinical signs. The treated animals exhibited normal feed intake and comparable body weight gain except for a decrease in females of 500 and 1000 mg/kg groups. Ocular examination revealed no abnormalities. Further, Zigbir® administration in rats did not induce any major changes in urinalysis, hematological, and biochemical evaluations except for minor alterations in few parameters at different dose levels. Gross and histopathological findings did not show any lesions attributable to Zigbir® administration. The no observed effect level of Zigbir® was found to be 500 and 250 mg/kg in male and female Sprague-Dawley rats.

scholarly journals A 4-Week Repeated-Dose Oral Toxicity Study of Bojungikgi-Tang in Crl:CD Sprague Dawley Rats

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Sae-Rom Yoo ◽  
Hyekyung Ha ◽  
Mee-Young Lee ◽  
Hyeun-Kyoo Shin ◽  
Su-Cheol Han ◽  
...  
Keyword(s):  
Body Weight ◽  
Food Intake ◽  
Serum Biochemistry ◽  
Toxicity Study ◽  
Repeated Dose ◽  
Sprague Dawley ◽  
Oral Toxicity ◽  
Organ Weights ◽  
Sprague Dawley Rats ◽  
Dose Oral

Traditional herbal medicines have been used for centuries in Asian countries. However, recent studies have led to increasing concerns about the safety and toxicity of herbal prescriptions. Bojungikgi-tang (BJIGT), a herbal decoction, has been used in Korea to improve physical strength. To establish the safety information, BJIGT water extract was evaluated in a 4-week repeated-dose oral toxicity test in Crl:CD Sprague Dawley rats. BJIGT was orally administered in daily doses of 0, 500, 1000, and 2000 mg/kg/day for 4 weeks via oral gavage in male and female rats. We examined the mortality, clinical signs, body weight change, food intake, organ weights, hematology, serum biochemistry, and urinalysis parameters. No significant changes were observed in mortality, clinical sings, body weight, food intake, organ weights, hematology, serum biochemistry, and urinalysis parameters between the control group and the BJIGT-treated groups in the rats of both sexes. The results indicate that BJIGT did not induce toxic effects at a dose level up to 2000 mg/kg in rats. Thus, this concentration is considered the nonobservable effect dose in rats and is appropriate for a 13-week subchronic toxicity study.

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