scholarly journals Targeted drug delivery by high intensity focused ultrasound mediated hyperthermia combined with temperature-sensitive liposomes: Computational modelling and preliminaryin vivovalidation

2012 ◽  
Vol 28 (4) ◽  
pp. 337-348 ◽  
Author(s):  
Astrid Gasselhuber ◽  
Matthew R. Dreher ◽  
Ari Partanen ◽  
Pavel S. Yarmolenko ◽  
David Woods ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Computational Modelling ◽  
High Intensity Focused Ultrasound ◽  
Temperature Sensitive ◽  
Targeted Drug

scholarly journals High Intensity Focused Ultrasound Technology, its Scope and Applications in Therapy and Drug Delivery

2014 ◽  
Vol 17 (1) ◽  
pp. 136 ◽  
Author(s):  
Christopher Peter Phenix ◽  
Melissa Togtema ◽  
Samuel Pichardo ◽  
Ingeborg Zehbe ◽  
Laura Curiel
Keyword(s):  
Drug Delivery ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Biological Effects ◽  
Pharmaceutical Research ◽  
Drug Carriers ◽  
High Intensity Focused Ultrasound ◽  
Temperature Sensitive ◽  
Therapeutic Applications ◽  
Living Tissues

Ultrasonography is a safe, inexpensive and wide-spread diagnostic tool capable of producing real-time non-invasive images without significant biological effects. However, the propagation of higher energy, intensity and frequency ultrasound waves through living tissues can induce thermal, mechanical and chemical effects useful for a variety of therapeutic applications. With the recent development of clinically approved High Intensity Focused Ultrasound (HIFU) systems, therapeutic ultrasound is now a medical reality.  Indeed, HIFU has been used for the thermal ablation of pathological lesions; localized, minimally invasive ultrasound-mediated drug delivery through the transient formation of pores on cell membranes; the temporary disruption of skin and the blood brain barrier; the ultrasound induced break-down of blood clots; and the targeted release of drugs using ultrasound and temperature sensitive drug carriers. This review seeks to engage the pharmaceutical research community by providing an overview on the biological effects of ultrasound as well as highlighting important therapeutic applications, current deficiencies and future directions.This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.

SPECT/CT imaging of temperature-sensitive liposomes for MR-image guided drug delivery with high intensity focused ultrasound

2013 ◽  
Vol 169 (1-2) ◽  
pp. 82-90 ◽  
Author(s):  
Mariska de Smet ◽  
Sander Langereis ◽  
Sandra van den Bosch ◽  
Katrin Bitter ◽  
Nicole M. Hijnen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
High Intensity ◽  
Focused Ultrasound ◽  
Ct Imaging ◽  
High Intensity Focused Ultrasound ◽  
Temperature Sensitive ◽  
Mr Image ◽  
Image Guided ◽  
Image Guided Drug Delivery
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