Application and functional characterization of POVACOAT, a hydrophilic co-polymer poly(vinyl alcohol/acrylic acid/methyl methacrylate) as a hot-melt extrusion carrier

2013 ◽  
Vol 40 (1) ◽  
pp. 126-135 ◽  
Author(s):  
Ming Xu ◽  
Chungang Zhang ◽  
Yanfei Luo ◽  
Lishuang Xu ◽  
Xiaoguang Tao ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Methyl Methacrylate ◽  
Vinyl Alcohol ◽  
Functional Characterization ◽  
Hot Melt Extrusion ◽  
Poly Vinyl Alcohol ◽  
Melt Extrusion ◽  
Acid Methyl ◽  
Hot Melt

Processability of poly(vinyl alcohol) Based Filaments With Paracetamol Prepared by Hot-Melt Extrusion for Additive Manufacturing

2020 ◽  
Vol 109 (12) ◽  
pp. 3636-3644
Author(s):  
Joana Macedo ◽  
Aseel Samaro ◽  
Valérie Vanhoorne ◽  
Chris Vervaet ◽  
João F. Pinto
Keyword(s):  
Additive Manufacturing ◽  
Vinyl Alcohol ◽  
Hot Melt Extrusion ◽  
Poly Vinyl Alcohol ◽  
Melt Extrusion ◽  
Hot Melt

scholarly journals Multifunctional Coatings for Robotic Implanted Device

2019 ◽  
Vol 20 (20) ◽  
pp. 5126 ◽  
Author(s):  
Caterina Cristallini ◽  
Serena Danti ◽  
Bahareh Azimi ◽  
Veronika Tempesti ◽  
Claudio Ricci ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Vinyl Alcohol ◽  
Soft Tissues ◽  
Functional Characterization ◽  
Titanium Substrate ◽  
Repair Process ◽  
Chemical Imaging ◽  
In Vitro Cytotoxicity ◽  
Poly Vinyl Alcohol

The objective of this study was the preparation and physico-chemical, mechanical, biological, and functional characterization of a multifunctional coating for an innovative, fully implantable device. The multifunctional coating was designed to have three fundamental properties: adhesion to device, close mechanical resemblance to human soft tissues, and control of the inflammatory response and tissue repair process. This aim was fulfilled by preparing a multilayered coating based on three components: a hydrophilic primer to allow device adhesion, a poly(vinyl alcohol) hydrogel layer to provide good mechanical compliance with the human tissue, and a layer of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) fibers. The use of biopolymer fibers offered the potential for a long-term interface able to modulate the release of an anti-inflammatory drug (dexamethasone), thus contrasting acute and chronic inflammation response following device implantation. Two copolymers, poly(vinyl acetate-acrylic acid) and poly(vinyl alcohol-acrylic acid), were synthetized and characterized using thermal analysis (DSC, TGA), Fourier transform infrared spectroscopy (FT-IR chemical imaging), in vitro cell viability, and an adhesion test. The resulting hydrogels were biocompatible, biostable, mechanically compatible with soft tissues, and able to incorporate and release the drug. Finally, the multifunctional coating showed a good adhesion to titanium substrate, no in vitro cytotoxicity, and a prolonged and controlled drug release.

scholarly journals Thermoanalytical characterization of clindamycin-loaded intravitreal implants prepared by hot melt extrusion

2015 ◽  
Vol 4 (1) ◽  
pp. 147 ◽  
Author(s):  
SeyedAbolfazl Mostafavi ◽  
Reza Karkhane ◽  
Mohammad Riazi-Esfahani ◽  
FaridAbedin Dorkoosh ◽  
Morteza Rafiee-Tehrani ◽  
...  
Keyword(s):  
Hot Melt Extrusion ◽  
Melt Extrusion ◽  
Hot Melt
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