In Vitro Studies Using Ion Exchange Resins as Potential Phosphaste Binders for Renal Failure Patients

1985 ◽  
Vol 9 (1) ◽  
pp. 35-44 ◽  
Author(s):  
Eugene C. Cameron ◽  
Marianna Leung ◽  
Hildegard Erber ◽  
John D.E. Price
Keyword(s):  
Renal Failure ◽  
Ion Exchange ◽  
In Vitro Studies ◽  
Ion Exchange Resins ◽  
Exchange Resins

Remineralization Potential of a New Toothpaste Formulation: An In-Vitro Study

2004 ◽  
Vol 5 (1) ◽  
pp. 18-30 ◽  
Author(s):  
Carlos A. Muñoz ◽  
Anna Torrado ◽  
Manuel Valiente ◽  
Wu Zhang ◽  
Yiming Li
Keyword(s):  
Ion Exchange ◽  
In Vitro Study ◽  
Ion Exchange Resin ◽  
Ion Exchange Resins ◽  
Experimental Conditions ◽  
Human Enamel ◽  
Before And After ◽  
Ph Cycling ◽  
Exchange Resins

Abstract The aim of the present study was to determine the ability of a dentifrice containing a mixture of ion-exchange resins (named NMTD), which supplies calcium, fluoride, phosphate, and zinc ions, to promote remineralization and/or inhibit demineralization of dental human enamel in a pH cycling model in vitro. A fluoride toothpaste was used as the control. The enamel specimens were tested for microhardness before and after 10 days and 16 days of the demineralizing and remineralizing treatments. The results of this study showed both dentifrices were effective in limiting in vitro enamel demineralization although the effects were not significantly different from each other. Inclusion of calcium and phosphate ion-exchange resins in the dentifrice containing a fluoride ion-exchange resin maintained a similar net outcome of the conventional dentifrice in the demineralization/ remineralization process under the experimental conditions employed. Citation Torrado A, Valiente M, Zhang W, et. al. Remineralization Potential of a New Toothpaste Formulation: An In-Vitro Study. J Contemp Dent Pract 2004 February;(5)1:018-030.

In vitro release of cytotoxic agents from ion exchange resins

1989 ◽  
Vol 8 (3) ◽  
pp. 251-257 ◽  
Author(s):  
C. Jones ◽  
M.A. Burton ◽  
B.N. Gray ◽  
J. Hodgkin
Keyword(s):  
Ion Exchange ◽  
In Vitro Release ◽  
Cytotoxic Agents ◽  
Ion Exchange Resins ◽  
Exchange Resins ◽  
Vitro Release

The Effects of Two Ion Exchange Resins on the Inhibition of Calculus-like Deposits In Vitro

1964 ◽  
Vol 35 (4) ◽  
pp. 296-301 ◽  
Author(s):  
Erwin M. Schaffer ◽  
Charles W. Schindler ◽  
Richard B. McHugh
Keyword(s):  
Ion Exchange ◽  
Ion Exchange Resins ◽  
Exchange Resins

scholarly journals Drug Crystal-Related Gastrointestinal Complications Involve Crystal-Induced Release of Neutrophil and Monocyte Extracellular Traps

Cells ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 2481 ◽  
Author(s):  
Tehyung Kim ◽  
Sueli de Oliveira Silva Lautenschlager ◽  
Qiuyue Ma ◽  
Kathrin Eller ◽  
Marion Julia Pollheimer ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Ion Exchange ◽  
Ion Exchange Resins ◽  
Barrier Dysfunction ◽  
Gastrointestinal Complications ◽  
Intestinal Necrosis ◽  
Extracellular Traps ◽  
Exchange Resins

Ion-exchange resins are commonly used to manage complications of chronic kidney disease, such as hyperphosphatemia, hyperkalemia, and hypercholesterolemia. Occasionally, these drugs can irritate the gastrointestinal lining and cause life-threatening intestinal necrosis. Currently, the pathophysiology of drug crystal-induced intestinal necrosis is not well understood. We hypothesized that crystals of ion-exchange resins like sevelamer, polystyrene sulfonate, and cholestyramine can trigger the formation of neutrophil and monocyte extracellular traps by contributing to intestinal barrier dysfunction. Light and fluorescence microscopy of the colonic resection specimen from a patient with chronic kidney disease revealed severe intestinal necrosis, ulceration, sevelamer crystals, and inflammation upon oral intake of sevelamer, as well as the formation of neutrophil extracellular traps in proximity to small sevelamer crystals. Indeed, drug crystals reduced metabolic activity and induced barrier dysfunction and cell death in human intestinal epithelial cells in vitro. In addition, drug crystals triggered the release of neutrophil and monocyte extracellular traps. Taken together, these data raise the possibility that besides other factors including chronic kidney disease, diabetes mellitus, and hypertension, drug crystals may further amplify a pre-existing barrier dysfunction and necroinflammation in a crescendo of local intestinal necrosis and systemic inflammation/infection, as occasionally observed in patients on ion-exchange resin therapy.

scholarly journals Comparison of the Removal of Radiostrontium from In Vivo- and In Vitro-Labeled Milk by Ion Exchange Resins

1963 ◽  
Vol 46 (12) ◽  
pp. 1362-1366 ◽  
Author(s):  
L.F. Edmondson ◽  
D.H. Keefer ◽  
F.W. Douglas ◽  
J.Y. Harris ◽  
E. Dodson
Keyword(s):  
Ion Exchange ◽  
Ion Exchange Resins ◽  
Exchange Resins

Embedding Procedure for Water Swollen Samples

1970 ◽  
Vol 28 ◽  
pp. 504-505
Author(s):  
Ann M. Thomas ◽  
Virginia Shemeley
Keyword(s):  
Electron Microscopy ◽  
Transmission Electron Microscopy ◽  
Ion Exchange ◽  
Structural Changes ◽  
Cross Linking ◽  
Ion Exchange Resins ◽  
Transmission Electron ◽  
First Pass ◽  
Exchange Resins

Those samples which swell rapidly when exposed to water are, at best, difficult to section for transmission electron microscopy. Some materials literally burst out of the embedding block with the first pass by the knife, and even the most rapid cutting cycle produces sections of limited value. Many ion exchange resins swell in water; some undergo irreversible structural changes when dried. We developed our embedding procedure to handle this type of sample, but it should be applicable to many materials that present similar sectioning difficulties.The purpose of our embedding procedure is to build up a cross-linking network throughout the sample, while it is in a water swollen state. Our procedure was suggested to us by the work of Rosenberg, where he mentioned the formation of a tridimensional structure by the polymerization of the GMA biproduct, triglycol dimethacrylate.

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