Nonrecurrent Hemolytic Uremic Syndrome (HUS de novo) as Cause of Acute Renal Failure After Renal Transplant

Introduction: Hemolytic-uremic syndrome (HUS) is a leading cause of acute renal failure in infants and young children. It is traditionally defined as a triad of acute renal failure, hemolytic anemia and thrombocytopenia that occur within a week after prodromal hemorrhagic enterocolitis. Severe cases can also be presented by acute respiratory distress syndrome (ARDS), toxic megacolon with ileus, pancreatitis, central nervous system (CNS) disorders and multiple organ failure (MOF).Case presentation: A previously healthy 4-year old Caucasian girl developed acute renal failure, thrombocytopenia and hemolytic anemia following a short episode of abdominal pain and bloody diarrhea. In the next week of, what initially appeared as typical HUS, she developed MOF, including ileus, pancreatitis, hepatitis, coma and ARDS, accompanied by hemodynamic instability and extreme leukocytosis. Nonetheless, the girl made a complete recovery after one month of the disease. She was successfully treated in the intensive care unit and significant improvement was noticed after plasmapheresis and continuous veno-venous hemodialysis.Conclusions: Early start of plasmapheresis and meticulous supportive treatment in the intensive care unit, including renal placement therapy, may be the therapy of choice in severe cases of HUS presented by MOF. Monitoring of prognostic factors is important for early performance of appropriate diagnostic and therapeutical interventions.

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Postoperative Atypical Hemolytic Uremic Syndrome in a 67-Year-Old Woman Associated with Hemolytic Anemia, Thrombocytopenia, and Acute Renal Failure

American Journal of Case Reports ◽

10.12659/ajcr.925662 ◽

2020 ◽

Vol 21 ◽

Author(s):

Arnab Chowdhury ◽

Megan P. Griffith ◽

Eric Busse ◽

Ahmed Khurshid Pasha

Keyword(s):

Renal Failure ◽

Acute Renal Failure ◽

Hemolytic Uremic Syndrome ◽

Hemolytic Anemia ◽

Atypical Hemolytic Uremic Syndrome ◽

Uremic Syndrome

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The Importance of Nonrenal Involvement in Hemolytic-Uremic Syndrome

PEDIATRICS ◽

10.1542/peds.65.1.115 ◽

1980 ◽

Vol 65 (1) ◽

pp. 115-120

Author(s):

Kirti Upadhyaya ◽

Kenneth Barwick ◽

Mark Fishaut ◽

Michael Kashgarian ◽

Norman J. Siegel

Keyword(s):

Renal Failure ◽

Acute Renal Failure ◽

Hemolytic Uremic Syndrome ◽

Clinical Course ◽

Important Determinant ◽

Clinical Manifestations ◽

Wide Distribution ◽

Effective Management ◽

Uremic Syndrome ◽

The Brain

Fifteen children with the clinical manifestations of hemolytic-uremic syndrome are reported.Prompt recognition of the syndrome and effective therapy for acute renal failure including early dialysis were institured in each case. Analysis of the clinical course and histopathologic features in these patients indicated that early dialysis and effective management of acute renal failure may unmask evidence of nonrenal involvement; microthrombi may be found in a wide distribution of organs, including the brain and myocardium; and extent and severity of nonrenal involvement become an important determinant of ultimate prognosis.

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Endothelin and Hemolytic Uremic Syndrome

PEDIATRICS ◽

10.1542/peds.89.6.1127b ◽

1992 ◽

Vol 89 (6) ◽

pp. 1127-1127

Author(s):

RICHARD E. SIEGLER

Keyword(s):

Renal Failure ◽

Acute Renal Failure ◽

Epithelial Cells ◽

Hemolytic Uremic Syndrome ◽

Renal Injury ◽

Mesangial Cells ◽

Renal Epithelial Cells ◽

Uremic Syndrome ◽

Urine Levels

In Reply.— Yasutomo is correct. We were careful to point out that endothelin is produced not only by endothehial cells, but also by cultured rat mesangial cells and porcine renal epithelial cells, and that its elevation in the urine of children with the hemolytic uremic syndrome may only be a marker of renal injury. Showing that elevated urine levels are limited to hemolytic uremic syndrome would certainly strengthen (but not prove) the argument that it plays a role in the pathogenesis of the acute renal failure of the syndrome.

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Case Report: Severe form of hemolytic-uremic syndrome with multiple organ failure in a child: a case report

F1000Research ◽

10.12688/f1000research.2546.2 ◽

2014 ◽

Vol 3 ◽

pp. 79

Author(s):

Dino Mijatovic ◽

Ana Blagaic ◽

Zeljko Zupan

Keyword(s):

Intensive Care Unit ◽

Renal Failure ◽

Acute Renal Failure ◽

Intensive Care ◽

Case Report ◽

Multiple Organ Failure ◽

Hemolytic Uremic Syndrome ◽

Organ Failure ◽

Multiple Organ ◽

Uremic Syndrome

Introduction: Hemolytic-uremic syndrome (HUS) is a leading cause of acute renal failure in infants and young children. It is traditionally defined as a triad of acute renal failure, hemolytic anemia and thrombocytopenia that occur within a week after prodromal hemorrhagic enterocolitis. Severe cases can also be presented by acute respiratory distress syndrome (ARDS), toxic megacolon with ileus, pancreatitis, central nervous system (CNS) disorders and multiple organ failure (MOF).Case presentation: A previously healthy 4-year old Caucasian girl developed acute renal failure, thrombocytopenia and hemolytic anemia following a short episode of abdominal pain and bloody diarrhea. By the end of the first week the diagnosis of the typical HUS was established. During the second week the disease progressed into MOF that included ileus, pancreatitis, hepatitis, coma and ARDS, accompanied by hemodynamic instability and extreme leukocytosis. Nonetheless, the girl made a complete recovery after one month of the disease. She was successfully treated in the intensive care unit and significant improvement was noticed after plasmapheresis and continuous veno-venous hemodialysis.Conclusions: Early start of plasmapheresis and meticulous supportive treatment in the intensive care unit, including renal placement therapy, may be the therapy of choice in severe cases of HUS presented by MOF. Monitoring of prognostic factors is important for early performance of appropriate diagnostic and therapeutical interventions.

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