The Importance of Nonrenal Involvement in Hemolytic-Uremic Syndrome

PEDIATRICS ◽  
1980 ◽  
Vol 65 (1) ◽  
pp. 115-120
Author(s):  
Kirti Upadhyaya ◽  
Kenneth Barwick ◽  
Mark Fishaut ◽  
Michael Kashgarian ◽  
Norman J. Siegel
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Hemolytic Uremic Syndrome ◽  
Clinical Course ◽  
Important Determinant ◽  
Clinical Manifestations ◽  
Wide Distribution ◽  
Effective Management ◽  
Uremic Syndrome ◽  
The Brain

Fifteen children with the clinical manifestations of hemolytic-uremic syndrome are reported.Prompt recognition of the syndrome and effective therapy for acute renal failure including early dialysis were institured in each case. Analysis of the clinical course and histopathologic features in these patients indicated that early dialysis and effective management of acute renal failure may unmask evidence of nonrenal involvement; microthrombi may be found in a wide distribution of organs, including the brain and myocardium; and extent and severity of nonrenal involvement become an important determinant of ultimate prognosis.

Acute Renal Failure Due to Hemolytic Uremic Syndrome in Adult Patients

Renal Failure ◽  
1997 ◽  
Vol 19 (2) ◽  
pp. 279-282 ◽  
Author(s):  
Yvoty A. S. Sens ◽  
Luiz A. Miorin ◽  
HÉLio G. C. Silva ◽  
Denise M.A.C Malheiros ◽  
Dino M. Filho ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Hemolytic Uremic Syndrome ◽  
Adult Patients ◽  
Uremic Syndrome

Hemolytic-uremic syndrome: Findings of post-acute renal failure in light and electron microscopy

2017 ◽  
Vol 41 (3) ◽  
pp. 227-233
Author(s):  
Wiesława Salwa-Żurawska ◽  
Jakub Żurawski ◽  
Aldona Woźniak ◽  
Elżbieta Bortkiewicz ◽  
Paweł Burchardt ◽  
...  
Keyword(s):  
Electron Microscopy ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Hemolytic Uremic Syndrome ◽  
Light And Electron Microscopy ◽  
Uremic Syndrome

scholarly journals Plasma Exchange in Acute Renal Failure Due to Postpartum Hemolytic-Uremic Syndrome

Nephron ◽  
1988 ◽  
Vol 50 (2) ◽  
pp. 167-168 ◽  
Author(s):  
F. Conte ◽  
M. Meroni ◽  
G. Battini ◽  
G. Ferrario ◽  
A. Tommasi ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Hemolytic Uremic Syndrome ◽  
Plasma Exchange ◽  
Uremic Syndrome

Prolongation of acute renal failure in two patients with hemolytic-uremic syndrome due to excessive plasma infusion therapy

1989 ◽  
Vol 3 (4) ◽  
pp. 420-423 ◽  
Author(s):  
Allison A. Eddy ◽  
Denis F. Geary ◽  
J. Williamson Balfe ◽  
W. F. Clark ◽  
Reuben Baumal
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Hemolytic Uremic Syndrome ◽  
Infusion Therapy ◽  
Plasma Infusion ◽  
Uremic Syndrome

scholarly journals Severe form of hemolytic-uremic syndrome with multiple organ failure in a child: a case report

F1000Research ◽  
2014 ◽  
Vol 3 ◽  
pp. 79
Author(s):  
Dino Mijatovic ◽  
Ana Blagaic ◽  
Zeljko Zupan
Keyword(s):  
Intensive Care Unit ◽  
Renal Failure ◽  
Acute Renal Failure ◽  
Intensive Care ◽  
Multiple Organ Failure ◽  
Hemolytic Uremic Syndrome ◽  
Organ Failure ◽  
Hemolytic Anemia ◽  
Multiple Organ ◽  
Uremic Syndrome

Introduction: Hemolytic-uremic syndrome (HUS) is a leading cause of acute renal failure in infants and young children. It is traditionally defined as a triad of acute renal failure, hemolytic anemia and thrombocytopenia that occur within a week after prodromal hemorrhagic enterocolitis. Severe cases can also be presented by acute respiratory distress syndrome (ARDS), toxic megacolon with ileus, pancreatitis, central nervous system (CNS) disorders and multiple organ failure (MOF).Case presentation: A previously healthy 4-year old Caucasian girl developed acute renal failure, thrombocytopenia and hemolytic anemia following a short episode of abdominal pain and bloody diarrhea. In the next week of, what initially appeared as typical HUS, she developed MOF, including ileus, pancreatitis, hepatitis, coma and ARDS, accompanied by hemodynamic instability and extreme leukocytosis. Nonetheless, the girl made a complete recovery after one month of the disease. She was successfully treated in the intensive care unit and significant improvement was noticed after plasmapheresis and continuous veno-venous hemodialysis.Conclusions: Early start of plasmapheresis and meticulous supportive treatment in the intensive care unit, including renal placement therapy, may be the therapy of choice in severe cases of HUS presented by MOF. Monitoring of prognostic factors is important for early performance of appropriate diagnostic and therapeutical interventions.

Endothelin and Hemolytic Uremic Syndrome

PEDIATRICS ◽  
1992 ◽  
Vol 89 (6) ◽  
pp. 1127-1127
Author(s):  
RICHARD E. SIEGLER
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Epithelial Cells ◽  
Hemolytic Uremic Syndrome ◽  
Renal Injury ◽  
Mesangial Cells ◽  
Renal Epithelial Cells ◽  
Uremic Syndrome ◽  
Urine Levels

In Reply.— Yasutomo is correct. We were careful to point out that endothelin is produced not only by endothehial cells, but also by cultured rat mesangial cells and porcine renal epithelial cells, and that its elevation in the urine of children with the hemolytic uremic syndrome may only be a marker of renal injury. Showing that elevated urine levels are limited to hemolytic uremic syndrome would certainly strengthen (but not prove) the argument that it plays a role in the pathogenesis of the acute renal failure of the syndrome.

Rhabdomyolysis in a case of free-base cocaine ("crack") overdose.

1989 ◽  
Vol 35 (7) ◽  
pp. 1547-1549 ◽  
Author(s):  
M A Jandreski ◽  
E W Bermes ◽  
R Leischner ◽  
S E Kahn
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Crack Cocaine ◽  
Clinical Course ◽  
Medical Center ◽  
Clinical Manifestations ◽  
Blood Chemistry ◽  
Free Base ◽  
Laboratory Findings ◽  
Remarkable Recovery

Abstract This is the case of a 27-year-old black man who was admitted to Loyola University Medical Center after a one-time experience of smoking free-base ("crack") cocaine. Clinical manifestations of the resulting cocaine intoxication were rhabdomyolysis, acute renal failure, and transient liver failure. This patient came to our attention because of the striking alterations in his blood-chemistry values, which indicated acute tissue damage, and his remarkable recovery within 96 h. We discuss the dramatic changes in the laboratory findings and the clinical course of this patient.

Nonrecurrent Hemolytic Uremic Syndrome (HUS de novo) as Cause of Acute Renal Failure After Renal Transplant

Renal Failure ◽  
1997 ◽  
Vol 19 (2) ◽  
pp. 271-277 ◽  
Author(s):  
Marilda Mazzali ◽  
Eliana Pires de Oliveira Dias ◽  
Maria Almerinda Vieira Fernandes Ribeiro-Alves ◽  
Eduardo Homsi ◽  
Gentil Alves-Filho
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Renal Transplant ◽  
Hemolytic Uremic Syndrome ◽  
De Novo ◽  
Uremic Syndrome
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