Expression of Rheumatoid Factor Idiotypes 17.109, 6b6.6 and 4c9 in the Sera of Pima Indians

Autoimmunity ◽  
1994 ◽  
Vol 18 (4) ◽  
pp. 251-258 ◽  
Author(s):  
Anne Davidson ◽  
Harold D. Keiser ◽  
Antonio Del Puente ◽  
Peter H. Bennett ◽  
Ralph Schrohenloher ◽  
...  
2002 ◽  
Vol 46 (7) ◽  
pp. 1729-1734 ◽  
Author(s):  
Ian Enzer ◽  
Graham Dunn ◽  
Lennart Jacobsson ◽  
Peter H. Bennett ◽  
William C. Knowler ◽  
...  

1967 ◽  
Vol 10 (3) ◽  
pp. 163-179 ◽  
Author(s):  
William M. O'Brien ◽  
Peter H. Bennett ◽  
Thomas A. Burch ◽  
Joseph J. Bunim

1997 ◽  
Vol 78 (02) ◽  
pp. 961-962 ◽  
Author(s):  
Hans P Kohler ◽  
May Boothby ◽  
Lynn McCormack ◽  
William C Knowler ◽  
Peter J Grant

1997 ◽  
Vol 77 (05) ◽  
pp. 0955-0958 ◽  
Author(s):  
Carole A Foy ◽  
Peter J Grant

SummaryPAI-2 is a fibrinolytic inhibitor produced predominantly by monocytes. Most PAI-2 is intracellular making study in clinical conditions difficult. Abnormalities in production may be associated with inflammation and fibrinolysis at sites of tissue damage such as the atherosclerotic plaque.PAI-2 gene variants have been described: variant A consists of Asn120, Asn404 and Ser413 and variant B consists of Asp120, Lys404 and Cys413. We designed a PCR-RFLP assay using primers spanning the region containing Asn/Lys404 and Ser/Cys413. Variant B contains an Mwol restriction site. We analysed 302 Pima Indians and 286 healthy Caucasian volunteers. To investigate relationships between genotype and vascular disease we analysed 333 Caucasian patients undergoing coronary angiography.Gene variant B was more common in the Pimas than in Caucasians (p <0.0001). There was no significant difference in genotype distribution between the volunteers and patients. In the patients there was no association between genotype and either a history of MI or extent of coronary atheroma.


JAMA ◽  
1966 ◽  
Vol 198 (4) ◽  
pp. 384-386
Author(s):  
I. Oreskes
Keyword(s):  

2018 ◽  
Vol 4 (2) ◽  
pp. 58-62
Author(s):  
Roksana Yeasmin ◽  
MA Muttalib ◽  
Kazi Nazneen Sultana ◽  
Nizamul Hoque Bhuiyan ◽  
Md Jamil Hasan Karami ◽  
...  

Background: Type 2 diabetes mellitus is a chronic disease characterized by relative or absolute deficiency of insulin, resulting in glucose intolerance.Objectives: The present study was planned to see the associations of serum uric acid with positive Rheumatoid factor in type 2 male diabetes mellitus patients. Methodology: This case control study was carried out at the department of Biochemistry at Ibrahim Medical College, Dhaka, Bangladesh. The duration of the study was from June 2015 to June 2016 for a period of one year. In this present study, male patients with type 2 diabetes mellitus were taken as case group and age and sex matched healthy male were taken as control group. Rheumatoid factor was measured from the blood of all case and control group respondents. Others blood para meters were also measured for the correlation with the diabetes mellitus patients.Results: In this present study, 110 male patients presented with type 2 diabetes mellitus were recruited as case and age and sex matched healthy male were recruited as control. More rheumatoid factor positive in type 2 DM male patients with the uric acid range between 6.5 to 9.5 mg/dL. The number of patients was 5 out of total 9 rheumatoid factor positive cases. In this study serum uric acid was significantly correlated with rheumatoid factor in type 2 male diabetic patients. Rheumatoid factor positive cases were taking insulin among 9 and it was statistically significantly associated (p<0.001). Conclusion: In this study serum uric acid is significantly associated with positive rheumatoid factor in type 2 male diabetic patients.Journal of Current and Advance Medical Research 2017;4(2):58-62


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