Increased γ-H2AX by exposure to a 60-Hz magnetic fields combined with ionizing radiation, but not hydrogen peroxide, in non-tumorigenic human cell lines

2014 ◽  
Vol 90 (4) ◽  
pp. 291-298 ◽  
Author(s):  
Hye Eun Yoon ◽  
Jae Seon Lee ◽  
Sung Ho Myung ◽  
Yun-Sil Lee
Keyword(s):  
Hydrogen Peroxide ◽  
Magnetic Fields ◽  
Ionizing Radiation ◽  
Cell Lines ◽  
Human Cell ◽  
Human Cell Lines

Kinetics of gene expression following exposure to 60 Hz, 2 mT magnetic fields in three human cell lines

1997 ◽  
Vol 43 (1) ◽  
pp. 1-6 ◽  
Author(s):  
George H. Harrison ◽  
Elizabeth K. Balcer-Kubiczek ◽  
Zhong-Ming Shi ◽  
Yiao-Feng Zhang ◽  
Welton A. McCready ◽  
...  
Keyword(s):  
Gene Expression ◽  
Magnetic Fields ◽  
Cell Lines ◽  
Human Cell ◽  
Human Cell Lines ◽  
Kinetics Of

scholarly journals Effects of Ionizing Radiation on Mitochondria in Human Cell Lines

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Erik Sweet ◽  
David Kwiatkowski ◽  
Jacquelyn Reynods ◽  
Robert O'Donnell ◽  
Wendy Pogozelski
Keyword(s):  
Ionizing Radiation ◽  
Cell Lines ◽  
Human Cell ◽  
Human Cell Lines

An Antisense Construct of Full-Length HumanRAD50cDNA Confers Sensitivity to Ionizing Radiation and Alkylating Agents on Human Cell Lines

2002 ◽  
Vol 157 (1) ◽  
pp. 19-25 ◽  
Author(s):  
Young Chul Kim ◽  
Jeong Tae Koh ◽  
Boo Ahn Shin ◽  
Kyu Youn Ahn ◽  
Bong Kyu Choi ◽  
...  
Keyword(s):  
Ionizing Radiation ◽  
Cell Lines ◽  
Human Cell ◽  
Alkylating Agents ◽  
Full Length ◽  
Human Cell Lines ◽  
Antisense Construct

scholarly journals 2195 Early induction of the II-5 promoter activity and IL-6 by ionizing radiation in human cell lines

1996 ◽  
Vol 36 (1) ◽  
pp. 372
Author(s):  
Ralf U. Peter ◽  
Juxian Lu ◽  
Alexander Beetz ◽  
Gerald Messer ◽  
Peter Kind
Keyword(s):  
Ionizing Radiation ◽  
Cell Lines ◽  
Human Cell ◽  
Promoter Activity ◽  
Human Cell Lines

scholarly journals An RNAi screen in human cell lines reveals conserved DNA damage repair pathways that mitigate formaldehyde sensitivity

2018 ◽  
Author(s):  
Eleonora Juarez ◽  
Nyasha Chambwe ◽  
Weiliang Tang ◽  
Asia D. Mitchell ◽  
Nichole Owen ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Dna Damage ◽  
Ionizing Radiation ◽  
Cell Line ◽  
Cell Lines ◽  
Human Cell ◽  
Cancer Cell Line ◽  
Human Cell Lines ◽  
Genetic Determinants ◽  
Formaldehyde Toxicity

ABSTRACTFormaldehyde is a ubiquitous DNA damaging agent, with human exposures occuring from both exogenous and endogenous sources. Formaldehyde can also form DNA-protein crosslinks and is representative of other such DNA damaging agents including ionizing radiation, metals, aldehydes, chemotherapeutics, and cigarette smoke. In order to identify genetic determinants of cell proliferation in response to continuous formaldehyde exposure, we quantified cell proliferation after siRNA-depletion of a comprehensive array of over 300 genes representing all of the major DNA damage response pathways. Three unrelated human cell lines (SW480, U-2 OS and GM00639) were used to identify common or cell line-specific mechanisms. Four cellular pathways were determined to mitigate formaldehyde toxicity in all three cell lines: homologous recombination, double-strand break repair, ionizing radiation response, and DNA replication. Differences between cell lines were further investigated by using exome sequencing and Cancer Cell Line Encyclopedia genomic data. Our results reveal major genetic determinants of formaldehyde toxicity in human cells and provide evidence for the conservation of these formaldehyde responses between human and budding yeast.

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