Cytotoxic properties of radionuclide-conjugated Cetuximab without and in combination with external irradiation in head and neck cancer cells in vitro

2014 ◽  
Vol 90 (8) ◽  
pp. 678-686 ◽  
Author(s):  
Iris Eke ◽  
Mirjam Ingargiola ◽  
Claudia Förster ◽  
Leoni A. Kunz-Schughart ◽  
Michael Baumann ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
External Irradiation

scholarly journals Ionizing radiation affects the composition of the proteome of extracellular vesicles released by head-and-neck cancer cells in vitro

2019 ◽  
Vol 60 (3) ◽  
pp. 289-297 ◽  
Author(s):  
Agata Abramowicz ◽  
Anna Wojakowska ◽  
Lukasz Marczak ◽  
Malgorzata Lysek-Gladysinska ◽  
Mateusz Smolarz ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Ionizing Radiation ◽  
Head And Neck ◽  
Cancer Cells ◽  
Extracellular Vesicles ◽  
Neck Cancer

scholarly journals Photodynamic therapy suppresses the migration and invasion of head and neck cancer cells in vitro

Oral Oncology ◽  
2007 ◽  
Vol 43 (4) ◽  
pp. 358-365 ◽  
Author(s):  
Ting-Hua Yang ◽  
Chin-Tin Chen ◽  
Cheng-Ping Wang ◽  
Pei-Jen Lou
Keyword(s):  
Head And Neck Cancer ◽  
Photodynamic Therapy ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Migration And Invasion

scholarly journals Methyl-donor depletion of head and neck cancer cells in vitro establishes a less aggressive tumour cell phenotype

2017 ◽  
Vol 57 (4) ◽  
pp. 1321-1332 ◽  
Author(s):  
Vanessa Hearnden ◽  
Hilary J. Powers ◽  
Abeir Elmogassabi ◽  
Rosanna Lowe ◽  
Craig Murdoch
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Tumour Cell ◽  
Cell Phenotype ◽  
Methyl Donor

scholarly journals EPHA3 Contributes to Epigenetic Suppression of PTEN in Radioresistant Head and Neck Cancer

Biomolecules ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 599
Author(s):  
Song-Hee Kim ◽  
Byung-Chul Kang ◽  
Daseul Seong ◽  
Won-Hyeok Lee ◽  
Jae-Hee An ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Dna Methyltransferase ◽  
Regulatory Mechanism ◽  
Dna Methyltransferase 1 ◽  
Epigenetic Suppression

EPHA3, a member of the EPH family, is overexpressed in various cancers. We demonstrated previously that EPHA3 is associated with radiation resistance in head and neck cancer via the PTEN/Akt/EMT pathway; the inhibition of EPHA3 significantly enhances the efficacy of radiotherapy in vitro and in vivo. In this study, we investigated the mechanisms of PTEN regulation through EPHA3-related signaling. Increased DNA methyltransferase 1 (DNMT1) and enhancer of zeste homolog 2 (EZH2) levels, along with increased histone H3 lysine 27 trimethylation (H3K27me3) levels, correlated with decreased levels of PTEN in radioresistant head and neck cancer cells. Furthermore, PTEN is regulated in two ways: DNMT1-mediated DNA methylation, and EZH2-mediated histone methylation through EPHA3/C-myc signaling. Our results suggest that EPHA3 could display a novel regulatory mechanism for the epigenetic regulation of PTEN in radioresistant head and neck cancer cells.

Anti-tumor activity of heptaplatin in combination with 5-fluorouracil or paclitaxel against human head and neck cancer cells in vitro

2006 ◽  
Vol 17 (4) ◽  
pp. 377-384 ◽  
Author(s):  
Jung-Won Lee ◽  
Jong-Kook Park ◽  
Sin-Hyung Lee ◽  
Seong-Yun Kim ◽  
Yong-Baik Cho ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
Human Head ◽  
Anti Tumor Activity

scholarly journals In Vitro Study of the Anti-cancer Effect of Alternate-day 5-Fluorouracil in Head and Neck Cancer Cells

2019 ◽  
Vol 39 (11) ◽  
pp. 6041-6047
Author(s):  
YORIHISA MORO ◽  
YASUNAO KOGASHIWA ◽  
HIROYUKI SAKURAI ◽  
RYO TAKAHASHI ◽  
TORU KIMURA ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Cells ◽  
Neck Cancer ◽  
In Vitro Study ◽  
Vitro Study ◽  
Anti Cancer
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