A novel drug delivery system of gold nanorods with doxorubicin and study of drug release by single molecule spectroscopy

We present the synthetic and release aspects of a novel drug delivery system (DDS) based on amido-functionalized POSS. DDS after drug release hydrolyses at pH = 7.40 to non-toxic products such as carboxylic acid salts and aminopropyl-POSS.

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Simultaneous monitoring of the drug release and antitumor effect of a novel drug delivery system-MWCNTs/DOX/TC

Drug Delivery ◽

10.1080/10717544.2016.1233592 ◽

2017 ◽

Vol 24 (1) ◽

pp. 143-151 ◽

Cited By ~ 20

Author(s):

Xia Dong ◽

Zhiting Sun ◽

Xiaoxiao Wang ◽

Dunwan Zhu ◽

Lanxia Liu ◽

...

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

Antitumor Effect ◽

Novel Drug Delivery System ◽

Novel Drug

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Intra Nasal In situ Gelling System of Lamotrigine Using Ion Activated Mucoadhesive Polymer

The Open Medicinal Chemistry Journal ◽

10.2174/1874104501711010222 ◽

2017 ◽

Vol 11 (1) ◽

pp. 222-244 ◽

Cited By ~ 5

Author(s):

Asha Paul ◽

K.M .Fathima ◽

Sreeja C. Nair

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

Evaluation Studies ◽

Nasal Administration ◽

Permeation Studies ◽

Novel Drug Delivery System ◽

Histopathological Studies ◽

Novel Drug

Background:A novel drug delivery system for treating acute epileptic condition.Objective:To develop an intranasal mucoadhesive formulation of Lamotrigine (LTG) loadedinsitugel, for the treatment of epilepsy to avoid possible side effects and first pass metabolism associated with conventional treatment.Methods:Lamotrigine was loaded into different polymeric solutions of gellan and xanthan gum.Results:All formulations subjected to various evaluation studies were within their acceptable limits. The pH of formulation ranges between 5.8 ±.001 to 6.8 ±.005 indicating that no mucosal irritation is expected as pH was in acceptable range.Invitrodrug release from the mucoadhesiveinsitugel formulations showed immediate drug release pattern with a maximum drug release of 97.02 ±0.54% for optimized G5 formulation within 20min.Exvivopermeation studies of optimized formulation G5 and control formulation was estimated.Exvivopermeation studies of G5insituformulation done for a period of 12 h resulted in slow, sustained release and greater permeability significance(P <0.05) through nasal mucosa when compared to control. Histopathological studies showed that G5 formulation was safer for nasal administration without any irritation. The stability studies indicated that gels were stable over 45 days in refrigerated condition (4±2ºC).Conclusion:The intranasalinsitugelling system is a promising novel drug delivery system for an antiepileptic drug lamotrigine which could enhance nasal residence time with increased viscosity and mucoadhesive character and provided better release profile of drug for treating acute epileptic conditions.

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Chitosan-based magnetic/fluorescent nanocomposites for cell labelling and controlled drug release

New Journal of Chemistry ◽

10.1039/c6nj02897g ◽

2017 ◽

Vol 41 (4) ◽

pp. 1736-1743 ◽

Cited By ~ 16

Author(s):

Yongling Ding ◽

Hong Yin ◽

Shirley Shen ◽

Kangning Sun ◽

Futian Liu

Keyword(s):

Drug Delivery ◽

Drug Release ◽

Drug Delivery System ◽

Delivery System ◽

Controlled Drug Release ◽

Cell Labelling ◽

Chitosan Matrix ◽

Novel Drug Delivery System ◽

Novel Drug

A novel drug delivery system, containing functional Fe3O4, CdTe@ZnS QDs, doxorubicin and a chitosan matrix, was designed via a polymer crosslinking method.

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