Solubilization of entecavir by povidone to overcome content uniformity challenges for low-dose tablet formulations

2012 ◽  
Vol 18 (6) ◽  
pp. 1305-1313 ◽  
Author(s):  
Divyakant Desai ◽  
Danping Li ◽  
Abizer Harianawala ◽  
Omar Sprockel ◽  
Ming Huang ◽  
...  
Keyword(s):  
Low Dose ◽  
Content Uniformity ◽  
Tablet Formulations ◽  
Dose Tablet

Improving the Content Uniformity of a Low-Dose Tablet Formulation Through Roller Compaction Optimization

2007 ◽  
Vol 12 (4) ◽  
pp. 391-404 ◽  
Author(s):  
Mary T. am Ende ◽  
Sara K. Moses ◽  
Anthony J. Carella ◽  
Rashmi A. Gadkari ◽  
Timothy W. Graul ◽  
...  
Keyword(s):  
Low Dose ◽  
Tablet Formulation ◽  
Roller Compaction ◽  
Content Uniformity ◽  
Dose Tablet

Bioequivalence study of low-dose diclofenac potassium tablet formulations

2009 ◽  
Vol 47 (10) ◽  
pp. 643-648 ◽  
Author(s):  
B. Hinz ◽  
A.M. Hug ◽  
G. Fotopoulos ◽  
M.S. Gold
Keyword(s):  
Low Dose ◽  
Bioequivalence Study ◽  
Tablet Formulations

New investigation of distribution imaging and content uniformity of very low dose drugs using hot-melt extrusion method

2013 ◽  
Vol 458 (2) ◽  
pp. 245-253 ◽  
Author(s):  
Jun-Bom Park ◽  
Chin-Yang Kang ◽  
Wie-Soo Kang ◽  
Han-Gon Choi ◽  
Hyo-Kyung Han ◽  
...  
Keyword(s):  
Low Dose ◽  
Hot Melt Extrusion ◽  
Content Uniformity ◽  
Melt Extrusion ◽  
Hot Melt ◽  
Extrusion Method

Validation of Liquid Chromatographic Method for Assay of Chlorthalidone in Tablet Formulations

1985 ◽  
Vol 68 (1) ◽  
pp. 96-98
Author(s):  
Jerry Fogel ◽  
Jay Sisco ◽  
Fritz Hess
Keyword(s):  
Parent Compound ◽  
Hydrolysis Product ◽  
Content Uniformity ◽  
Reverse Phase ◽  
General Utility ◽  
Liquid Chromatographic Method ◽  
Phase Liquid ◽  
Tablet Formulations ◽  
Low Levels ◽  
Liquid Chromatographic

Abstract A stability-indicating, reverse phase liquid chromatographic (LC) method was developed for assay of chlorthalidone in tablet formulations. The chromatographic system separates the parent compound from its potential hydrolysis product (4'-chIoro-3'-sulfamoyl-2-benzophenone carboxylic acid), which can be quantitated at low levels, and another degradation product (2-chloro-5-(l-methoxy-3-oxo-l-isoindolinyl)benzenesulfonamide), which was found during the experimental work. The procedure can also be used for content uniformity determinations. The general utility of the method was demonstrated by the assay of several product brands. The validated procedure was shown to be accurate, precise, reproducible, and specific.

Factor analysis in optimization of formulation of high content uniformity tablets containing low dose active substance

2017 ◽  
Vol 109 ◽  
pp. 541-547 ◽  
Author(s):  
Ivana Lukášová ◽  
Jan Muselík ◽  
Aleš Franc ◽  
Roman Goněc ◽  
Filip Mika ◽  
...  
Keyword(s):  
Factor Analysis ◽  
Active Substance ◽  
Low Dose ◽  
Content Uniformity
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