Preparation and evaluation of luteolin–phospholipid complex as an effective drug delivery tool against GalN/LPS induced liver damage

2015 ◽  
pp. 1-12 ◽  
Author(s):  
Junaid Khan ◽  
Swarnlata Saraf ◽  
Shailendra Saraf
Keyword(s):  
Drug Delivery ◽  
Liver Damage ◽  
Effective Drug ◽  
Phospholipid Complex ◽  
Preparation And Evaluation

scholarly journals Preparation and Evaluation of a Self-Nanoemulsifying Drug Delivery System Loaded with Heparin Phospholipid Complex

2021 ◽  
Vol 22 (8) ◽  
pp. 4077
Author(s):  
Xiao-Lei Qiu ◽  
Zi-Rui Fan ◽  
Yang-Yang Liu ◽  
Ding-Fu Wang ◽  
Shi-Xin Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Administration ◽  
Drug Delivery System ◽  
Delivery System ◽  
Thrombin Time ◽  
Phospholipid Complex ◽  
Scanning Calorimetry ◽  
Ft Ir ◽  
Preparation And Evaluation ◽  
Ft Ir Spectroscopy

A self-nanoemulsifying drug delivery system (SNEDDS) was developed to enhance the absorption of heparin after oral administration, in which heparin was compounded with phospholipids to achieve better fat solubility in the form of heparin-phospholipid (HEP-Pc) complex. HEP-Pc complex was prepared using the solvent evaporation method, which increased the solubility of heparin in n-octanol. The successful preparation of HEP-Pc complex was confirmed by differential scanning calorimetry (DSC), Fourier-transform infrared (FT-IR) spectroscopy, NMR, and SEM. A heparin lipid microemulsion (HEP-LM) was prepared by high-pressure homogenization and characterized. HEP-LM can enhance the absorption of heparin after oral administration, significantly prolong activated partial thromboplastin time (APTT) and thrombin time (TT) in mice, and reduce fibrinogen (FIB) content. All these outcomes indicate that HEP-LM has great potential as an oral heparin formulation.

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