The effect of bone morphogenic protein-2-coated tri-calcium phosphate/hydroxyapatite on new bone formation in a rat model of femoral distraction osteogenesis

Cytotherapy ◽  
2012 ◽  
Vol 14 (3) ◽  
pp. 315-326 ◽  
Author(s):  
Jae-Hyuk Yang ◽  
Hak-Jun Kim ◽  
Sung-Eun Kim ◽  
Young-Pil Yun ◽  
Ji-Hoon Bae ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Distraction Osteogenesis ◽  
Rat Model ◽  
Bone Morphogenic Protein ◽  
New Bone Formation ◽  
Bone Morphogenic Protein 2

Recombinant Human Platelet-Derived Growth Factor-BB Augmentation of New-Bone Formation in a Rat Model of Distraction Osteogenesis

2009 ◽  
Vol 91 (8) ◽  
pp. 1973-1984 ◽  
Author(s):  
Douglas C Moore ◽  
Michael G Ehrlich ◽  
Scott C McAllister ◽  
Jason T Machan ◽  
Charles E Hart ◽  
...  
Keyword(s):  
Growth Factor ◽  
Bone Formation ◽  
Distraction Osteogenesis ◽  
Rat Model ◽  
Human Platelet ◽  
Platelet Derived Growth Factor ◽  
New Bone Formation

scholarly journals Sclerostin antibody enhances bone formation in a rat model of distraction osteogenesis

2018 ◽  
Author(s):  
Michelle M. McDonald ◽  
Alyson Morse ◽  
Oliver Birke ◽  
Nicole Y. C. Yu ◽  
Kathy Mikulec ◽  
...  
Keyword(s):  
Bone Formation ◽  
Distraction Osteogenesis ◽  
Rat Model ◽  
Sclerostin Antibody

The evaluation of the effects of hyperbaric oxygen therapy on new bone formation obtained by distraction osteogenesis in terms of consolidation periods

2011 ◽  
Vol 16 (5) ◽  
pp. 1363-1370 ◽  
Author(s):  
Ibrahim Mutlu ◽  
Yavuz Sinan Aydintug ◽  
Ayper Kaya ◽  
Gurkan Rasit Bayar ◽  
Berkay Tolga Suer ◽  
...  
Keyword(s):  
Bone Formation ◽  
Hyperbaric Oxygen ◽  
Distraction Osteogenesis ◽  
Hyperbaric Oxygen Therapy ◽  
Oxygen Therapy ◽  
New Bone Formation

In Vitro and In Vivo Evaluation Of Calcium Phosphate Bone Graft Substitutes

2010 ◽  
Vol 654-656 ◽  
pp. 2065-2070
Author(s):  
Ho Yeon Song ◽  
Young Hee Kim ◽  
Jyoti M. Anirban ◽  
In Seon Byun ◽  
Kyung A Kwak ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Formation ◽  
Bone Graft ◽  
Cellular Proliferation ◽  
New Bone Formation ◽  
Hydroxy Apatite ◽  
Defect Sites ◽  
Bone Graft Substitutes

Calcium phosphate ceramics such as hydroxy apatite (HA), β-tricalcium phosphate (β-TCP) and bicalcium phosphate (BCP) have been used as a bone graft biomaterial because of their good biocompatibility and similarity of chemical composition to natural bones. To increase the mechanical and osteoconductive properties, the granules and spongy type porous bone graft substitutes were prepared by fibrous monolithic process and polyurethane foam replica methods, respectively. The pore sizes obtained using these approaches ranged between 100-600 µm. The cytotoxicity, cellular proliferation, differentiation and ECM deposition on the bone graft substitutes were observed by SEM and confocal microscopy. Moreover, the scaffolds were implanted in the rabbit femur. New bone formation and biodegradation of bone graft were observed through follow-up X-ray, micro-CT analysis and histological findings. After several months (2, 3, 6, 12 and 24 months) of implantation, new bone formation and ingrowths were observed in defect sites of the animal by CaP ceramics and 2 to 3 times higher bone ingrowths were confirmed than that of the normal trabecular bones in terms of total bone volume (BV).

Effect of Particle Size on New Bone Formation In Vivo Using Calcium Phopshate Glass

2007 ◽  
Vol 330-332 ◽  
pp. 165-168
Author(s):  
Hyun Ju Moon ◽  
Racquel Z. LeGeros ◽  
Kyoung Nam Kim ◽  
Kwang Mahn Kim ◽  
Seong Ho Choi ◽  
...  
Keyword(s):  
Particle Size ◽  
Calcium Phosphate ◽  
Bone Formation ◽  
Phosphate Glass ◽  
Glass Powder ◽  
New Bone Formation ◽  
Sprague Dawley ◽  
Constant Weight ◽  
Calvarial Defects

The purpose of this study was to compare the bone regenerative effect of calcium phosphate glass according to the particle size in vivo. We prepared two different sizes, that is 400 μm and 40 μm, of calcium phosphate glass powder using the system CaO-CaF2-P2O5-MgO-ZnO. Critical-sized calvarial defects were created in 60 male Sprague-Dawley rats. The animals were divided into 3 groups of 20 animals each. Each defect was filled with a constant weight of 0.5 g calcium phosphate glass powder mixed with saline. As controls, the defect was left empty. The rats were sacrificed 2 or 8 weeks after postsurgery, and the results were evaluated using histological as well as histomorphometrical studies. The particle size of the calcium phosphate was crucial; 400 μm particles promoted new bone formation, while 40 μm particles inhibited it because of severe inflammation.

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