scholarly journals Role of NLRP3 inflammasome inBifidobacterium longum-regulated visceral hypersensitivity of postinfectious irritable bowel syndrome

2015 ◽  
Vol 44 (8) ◽  
pp. 1933-1937 ◽  
Author(s):  
Qiao-Yan Gu ◽  
Jun Zhang ◽  
Yi-Chao Feng
Keyword(s):  
Irritable Bowel Syndrome ◽  
Nlrp3 Inflammasome ◽  
Visceral Hypersensitivity ◽  
Irritable Bowel ◽  
Postinfectious Irritable Bowel Syndrome

Sensitivity Testing in Irritable Bowel Syndrome With Rectal Capsaicin Stimulations: Role of TRPV1 Upregulation and Sensitization in Visceral Hypersensitivity?

2014 ◽  
Vol 109 (1) ◽  
pp. 99-109 ◽  
Author(s):  
Sander J M van Wanrooij ◽  
Mira M Wouters ◽  
Lukas Van Oudenhove ◽  
Winde Vanbrabant ◽  
Stéphanie Mondelaers ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Visceral Hypersensitivity ◽  
Sensitivity Testing ◽  
Irritable Bowel

Possible role of nitric oxide in visceral hypersensitivity in patients with irritable bowel syndrome

2006 ◽  
Vol 18 (2) ◽  
pp. 115-122 ◽  
Author(s):  
s. d. kuiken ◽  
t. k. klooker ◽  
g. n. tytgat ◽  
a. lei ◽  
g. e. boeckxstaens
Keyword(s):  
Nitric Oxide ◽  
Irritable Bowel Syndrome ◽  
Visceral Hypersensitivity ◽  
Irritable Bowel

scholarly journals Electroacupuncture Relieves Visceral Hypersensitivity by Inactivating Protease-Activated Receptor 2 in a Rat Model of Postinfectious Irritable Bowel Syndrome

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Wanli Xu ◽  
Mengqian Yuan ◽  
Xiaoliang Wu ◽  
Hao Geng ◽  
Lu Chen ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Rat Model ◽  
Analgesic Effect ◽  
Molecular Mechanisms ◽  
Critical Role ◽  
Visceral Hypersensitivity ◽  
Mrna Levels ◽  
Irritable Bowel ◽  
Protease Activated Receptor 2 ◽  
Postinfectious Irritable Bowel Syndrome

Background. The role of protease-activated receptor 2 (PAR2) in the analgesic effect of electroacupuncture (EA) on visceral hypersensitivity (VH) in postinfectious irritable bowel syndrome (PI-IBS) has yet to be elucidated. Aim. In this study, we investigated the molecular mechanisms underlying the analgesic effect of EA in a rat model of PI-IBS. Methods. Visceral hypersensitivity was evaluated by the abdominal withdrawal reflex test before and after administration of the PAR2 agonist, PAR2-AP, and/or EA. The protein expression and mRNA levels of PAR2, CGRP, SP, and TPSP in colon tissues were measured by immunofluorescence, western blot, and RT-PCR. Results. We found that EA could alleviate VH and significantly decrease protein and mRNA levels of PAR2, TPSP, CGRP, and SP in PI-IBS rats. The analgesic effect of EA on VH was slightly reduced in the presence of PAR2-AP. Conclusions. These results suggest that EA alleviates VH symptoms through downregulation of the levels of the TPSP/PAR2/SP/CGRP signaling axis in colon tissues in PI-IBS rats. Together, our data suggests that PAR2 plays a critical role in the analgesic effect of EA on VH in PI-IBS.

scholarly journals Visceral hypersensitivity in inflammatory bowel diseases and irritable bowel syndrome: The role of proteases

2016 ◽  
Vol 22 (47) ◽  
pp. 10275 ◽  
Author(s):  
Hannah Ceuleers ◽  
Hanne Van Spaendonk ◽  
Nikita Hanning ◽  
Jelena Heirbaut ◽  
Anne-Marie Lambeir ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Inflammatory Bowel Diseases ◽  
Visceral Hypersensitivity ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Irritable Bowel
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