scholarly journals Differential expression of glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
High Density Lipoprotein ◽  
Differential Expression ◽  
Binding Protein ◽  
Density Lipoprotein ◽  
Normal Breast ◽  
High Density ◽  
Differentially Expressed ◽  
Primary Tumors ◽  
Lipoprotein Binding

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1, GPIHB1, when comparing primary tumors of the breast to the tissue of origin, the normal breast. GPIHB1 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of GPIHB1 in primary tumors of the breast was correlated with distant metastasis-free survival in patients with luminal B subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. GPIHB1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of fatty acid binding protein 4 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Fatty Acid ◽  
Differential Expression ◽  
Fatty Acid Binding Protein ◽  
Binding Protein ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Primary Tumors ◽  
Fatty Acid Binding ◽  
Acid Binding Protein

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding fatty acid binding protein 4, FABP4, when comparing primary tumors of the breast to the tissue of origin, the normal breast. FABP4 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of FABP4 in primary tumors of the breast was correlated with recurrence-free survival in patients with HER2+ cancers, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. FABP4 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of single-stranded DNA-binding protein 1 (SSB1) in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Dna Binding ◽  
Differential Expression ◽  
Binding Protein ◽  
Dna Binding Protein ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Significant Differential Expression ◽  
Single Stranded Dna ◽  
Primary Tumors

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the nucleic acid binding protein 2, NABP2, also known as SSB1 (single-stranded DNA-binding protein 1) and OBFC2B (oligonucleotide/oligosaccharide-binding fold-containing protein 2B), when comparing primary tumors of the breast to the tissue of origin, the normal breast. SSB1 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. SSB1 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of SSB1 in primary tumors of the breast was correlated with recurrence-free survival in patients with basal subtype cancer. SSB1 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of cortactin binding protein 2 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Molecular Subtype ◽  
Binding Protein ◽  
Differentially Expressed Gene ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Significant Differential Expression ◽  
Primary Tumors

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding cortactin binding protein 2, CTTNBP2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. CTTNBP2 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. CTTNBP2 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of CTTNBP2 in primary tumors of the breast was correlated with post-progression survival in patients with luminal B subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. CTTNBP2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of RNA-binding protein with multiple splicing 2 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Rna Binding ◽  
Binding Protein ◽  
Rna Binding Protein ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Significant Differential Expression ◽  
Primary Tumors

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding RNA-binding protein with multiple splicing 2, RBPMS2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. RBPMS2 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of RBPMS2 in primary tumors of the breast was correlated with overall survival in patients with basal-like and luminal B subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. RBPMS2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of insulin-like growth factor binding protein 6 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Growth Factor ◽  
Differential Expression ◽  
Binding Protein ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Insulin Like Growth Factor ◽  
Significant Differential Expression ◽  
Primary Tumors ◽  
Factor Binding

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding insulin-like growth factor binding protein 6, IGFBP6, when comparing primary tumors of the breast to the tissue of origin, the normal breast. IGFBP6 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of IGFBP6 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancers in a contrary manner, demonstrating a complex relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. IGFBP6 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of LIM domain binding 2 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Molecular Subtype ◽  
Differentially Expressed Gene ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Lim Domain ◽  
Significant Differential Expression ◽  
Primary Tumors

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding LIM domain binding 2, LDB2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. LDB2 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of LDB2 in primary tumors of the breast was correlated with recurrence-free survival in patients with luminal A subtype cancers, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by molecular subtype. LDB2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of Rho GTPase-activating protein 20 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Rho Gtpase ◽  
Differentially Expressed Gene ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Gtpase Activating Protein ◽  
Significant Differential Expression ◽  
Primary Tumors

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding Rho GTPase-activating protein 20, ARHGAP20, when comparing primary tumors of the breast to the tissue of origin, the normal breast. ARHGAP20 mRNA was present at significantly lower quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of ARHGAP20 in primary tumors of the breast was correlated with overall survival in patients with HER2+ subtype cancer, demonstrating a relationship between primary tumor expression of a differentially expressed gene and patient survival outcomes influenced by PAM50 molecular subtype. ARHGAP20 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

scholarly journals Differential expression of CKS2 in cancers of the breast.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Breast Cancer ◽  
Differential Expression ◽  
Survival Data ◽  
Normal Breast ◽  
Differentially Expressed ◽  
Regulatory Subunit ◽  
Luminal A ◽  
Gene Encoding ◽  
Significant Differential Expression ◽  
Primary Tumors

Breast cancer affects women at relatively high frequency (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with breast cancer. We report here significant differential expression of the gene encoding the CDC28 protein kinase regulatory subunit 2, CKS2, when comparing primary tumors of the breast to the tissue of origin, the normal breast. CKS2 was also differentially expressed in the tumor cells of patients with triple negative breast cancer. CKS2 mRNA was present at significantly higher quantities in tumors of the breast as compared to normal breast tissue. Analysis of human survival data revealed that expression of CKS2 in primary tumors of the breast was correlated with overall survival in patients with basal and luminal A subtype cancer, but in a contrary manner. CKS2 may be of relevance to initiation, maintenance or progression of cancers of the female breast.

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